Cancer Cell, volume 35, issue 6, pages 932-947.e8

Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes

Xue Ruidong ¹

Lu Chen

Zhang Chong ¹

Fujita Masashi ²

Li Ruo-Yan ¹

Yan Shu-mei ³

Ong Chin-Ann Johnny ⁴

Liao Xiwen ⁵

Gao Qiang ^{6, 7}

Sasagawa Shota ²

Li Yang ¹

Wang Jincheng ¹

Guo Hua ⁸

Huang Qi-tao ³

Zhong Qian ³

Tan Jing ³

QI LISHA ⁹

Gong Wenchen ⁹

Hong Zhixian ¹⁰

Li Meng ¹¹

Zhao Jingmin ¹²

Peng Tao ⁵

Lu Yinying ¹³

Lim Kiat Hon Tony ¹⁴

Boot Arnoud ¹⁵

Ono Atushi ¹⁶

Chayama Kazuaki ¹⁶

Zhang Zemin ¹

Rozen Steven G ¹⁵

Teh Bin S. ¹⁷

Wang Xin-Wei ¹⁸

Nakagawa Hidewaki ²

Zeng Musheng ³

Bai Fan ¹

Wang Jiadong ^{19, 20}

Hide authors affiliations Show authors affiliations: 20 affiliations

Biomedical Pioneering Innovation Center (BIOPIC) and Translational Cancer Research Center, School of Life Sciences, First Hospital, Peking University, Beijing, 100871, China. |

Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan |

State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat‐sen University Cancer Center Guangzhou 510060 China |

⁴

Lymphoma Genomic Translational Research Laboratory, Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore 169610, Singapore |

⁵

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China |

⁶

Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai 200032, China |

⁷

Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University |

⁸

Laboratory of Cancer Cell Biology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China |

⁹

Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China. |

¹⁰

Department of Hepatobiliary Surgery, Beijing 302 Hospital, Beijing 100039, China |

¹¹

Department of Ultrasonography, Beijing 302 Hospital, Beijing 100039, China |

¹²

Department of Pathology and Hepatology, Beijing 302 Hospital, Beijing 100039, China |

¹³

Comprehensive Liver Cancer Center, Beijing 302 Hospital, Beijing 100039, China |

¹⁴

Department of Anatomical Pathology, Singapore General Hospital, Singapore 169608, Singapore |

¹⁵

Centre for Computational Biology, Duke-NUS Medical School, Singapore 169857, Singapore. |

¹⁶

Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan |

¹⁷

Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, Singapore 169610, Singapore |

¹⁸

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA |

¹⁹

Laboratory of Cancer Cell Biology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China |

²⁰

Biomedical Pioneering Innovation Center (BIOPIC) and Translational Cancer Research Center, School of Life Sciences, First Hospital, Peking University, Beijing 100871, China |

Publication type: Journal Article

Publication date: 2019-06-01

Elsevier

Journal: Cancer Cell

Quartile SCImago

Quartile WOS

Impact factor: 50.3

ISSN: 15356108, 18783686

DOI: 10.1016/j.ccell.2019.04.007

Copy DOI

PubMed ID: 31130341

Cancer Research

Oncology

Abstract

We performed genomic and transcriptomic sequencing of 133 combined hepatocellular and intrahepatic cholangiocarcinoma (cHCC-ICC) cases, including separate, combined, and mixed subtypes. Integrative comparison of cHCC-ICC with hepatocellular carcinoma and intrahepatic cholangiocarcinoma revealed that combined and mixed type cHCC-ICCs are distinct subtypes with different clinical and molecular features. Integrating laser microdissection, cancer cell fraction analysis, and single nucleus sequencing, we revealed both mono- and multiclonal origins in the separate type cHCC-ICCs, whereas combined and mixed type cHCC-ICCs were all monoclonal origin. Notably, cHCC-ICCs showed significantly higher expression of Nestin, suggesting Nestin may serve as a biomarker for diagnosing cHCC-ICC. Our results provide important biological and clinical insights into cHCC-ICC.

By date By citations

Citations by journals

	1 2 3 4 5 6 7 8 9
Cancers	Cancers, 9, 5.39% Cancers 9 publications, 5.39%
Journal of Hepatology	Journal of Hepatology, 8, 4.79% Journal of Hepatology 8 publications, 4.79%
Nature Communications	Nature Communications, 6, 3.59% Nature Communications 6 publications, 3.59%
Hepatology	Hepatology, 5, 2.99% Hepatology 5 publications, 2.99%
Frontiers in Oncology	Frontiers in Oncology, 5, 2.99% Frontiers in Oncology 5 publications, 2.99%
Nature Reviews Gastroenterology and Hepatology	Nature Reviews Gastroenterology and Hepatology, 4, 2.4% Nature Reviews Gastroenterology and Hepatology 4 publications, 2.4%
Histopathology	Histopathology, 4, 2.4% Histopathology 4 publications, 2.4%
Journal of Cancer Research and Clinical Oncology	Journal of Cancer Research and Clinical Oncology, 3, 1.8% Journal of Cancer Research and Clinical Oncology 3 publications, 1.8%
Frontiers in Immunology	Frontiers in Immunology, 3, 1.8% Frontiers in Immunology 3 publications, 1.8%
BMC Cancer	BMC Cancer, 3, 1.8% BMC Cancer 3 publications, 1.8%
Scientific Reports	Scientific Reports, 3, 1.8% Scientific Reports 3 publications, 1.8%
Gut	Gut, 3, 1.8% Gut 3 publications, 1.8%
International Journal of Surgical Pathology	International Journal of Surgical Pathology, 2, 1.2% International Journal of Surgical Pathology 2 publications, 1.2%
Journal of Translational Medicine	Journal of Translational Medicine, 2, 1.2% Journal of Translational Medicine 2 publications, 1.2%
Oncogene	Oncogene, 2, 1.2% Oncogene 2 publications, 1.2%
Communications Biology	Communications Biology, 2, 1.2% Communications Biology 2 publications, 1.2%
Nature	Nature, 2, 1.2% Nature 2 publications, 1.2%
Cancer Cell	Cancer Cell, 2, 1.2% Cancer Cell 2 publications, 1.2%
Heliyon	Heliyon, 2, 1.2% Heliyon 2 publications, 1.2%
Liver International	Liver International, 2, 1.2% Liver International 2 publications, 1.2%
Journal of Hepatocellular Carcinoma	Journal of Hepatocellular Carcinoma, 2, 1.2% Journal of Hepatocellular Carcinoma 2 publications, 1.2%
Briefings in Bioinformatics	Briefings in Bioinformatics, 2, 1.2% Briefings in Bioinformatics 2 publications, 1.2%
Science advances	Science advances, 2, 1.2% Science advances 2 publications, 1.2%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 2, 1.2% International Journal of Molecular Sciences 2 publications, 1.2%
Translational Cancer Research	Translational Cancer Research, 2, 1.2% Translational Cancer Research 2 publications, 1.2%
Zeitschrift fur Gastroenterologie	Zeitschrift fur Gastroenterologie, 2, 1.2% Zeitschrift fur Gastroenterologie 2 publications, 1.2%
Frontiers in Genetics	Frontiers in Genetics, 1, 0.6% Frontiers in Genetics 1 publication, 0.6%
Current Bioinformatics	Current Bioinformatics, 1, 0.6% Current Bioinformatics 1 publication, 0.6%
Aging	Aging, 1, 0.6% Aging 1 publication, 0.6%
	1 2 3 4 5 6 7 8 9

Citations by publishers

	5 10 15 20 25 30 35 40 45 50
Springer Nature	Springer Nature, 49, 29.34% Springer Nature 49 publications, 29.34%
Elsevier	Elsevier, 27, 16.17% Elsevier 27 publications, 16.17%
Wiley	Wiley, 18, 10.78% Wiley 18 publications, 10.78%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 14, 8.38% Multidisciplinary Digital Publishing Institute (MDPI) 14 publications, 8.38%
Frontiers Media S.A.	Frontiers Media S.A., 10, 5.99% Frontiers Media S.A. 10 publications, 5.99%
Wolters Kluwer Health	Wolters Kluwer Health, 4, 2.4% Wolters Kluwer Health 4 publications, 2.4%
SAGE	SAGE, 4, 2.4% SAGE 4 publications, 2.4%
Oxford University Press	Oxford University Press, 4, 2.4% Oxford University Press 4 publications, 2.4%
American Association for Cancer Research (AACR)	American Association for Cancer Research (AACR), 4, 2.4% American Association for Cancer Research (AACR) 4 publications, 2.4%
Dove Medical Press	Dove Medical Press, 3, 1.8% Dove Medical Press 3 publications, 1.8%
BMJ	BMJ, 3, 1.8% BMJ 3 publications, 1.8%
AME Publishing Company	AME Publishing Company, 3, 1.8% AME Publishing Company 3 publications, 1.8%
Taylor & Francis	Taylor & Francis, 2, 1.2% Taylor & Francis 2 publications, 1.2%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 2, 1.2% American Association for the Advancement of Science (AAAS) 2 publications, 1.2%
Thieme	Thieme, 2, 1.2% Thieme 2 publications, 1.2%
Bentham Science	Bentham Science, 1, 0.6% Bentham Science 1 publication, 0.6%
Impact Journals	Impact Journals, 1, 0.6% Impact Journals 1 publication, 0.6%
Spandidos Publications	Spandidos Publications, 1, 0.6% Spandidos Publications 1 publication, 0.6%
Baishideng Publishing Group	Baishideng Publishing Group, 1, 0.6% Baishideng Publishing Group 1 publication, 0.6%
American Society for Biochemistry and Molecular Biology	American Society for Biochemistry and Molecular Biology, 1, 0.6% American Society for Biochemistry and Molecular Biology 1 publication, 0.6%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 1, 0.6% Public Library of Science (PLoS) 1 publication, 0.6%
KeAi Communications Co.	KeAi Communications Co., 1, 0.6% KeAi Communications Co. 1 publication, 0.6%
Pacini Editore SpA	Pacini Editore SpA, 1, 0.6% Pacini Editore SpA 1 publication, 0.6%
American Society of Clinical Oncology (ASCO)	American Society of Clinical Oncology (ASCO), 1, 0.6% American Society of Clinical Oncology (ASCO) 1 publication, 0.6%
Annual Reviews	Annual Reviews, 1, 0.6% Annual Reviews 1 publication, 0.6%
Hans Publishers	Hans Publishers, 1, 0.6% Hans Publishers 1 publication, 0.6%
Cairo University	Cairo University, 1, 0.6% Cairo University 1 publication, 0.6%
	5 10 15 20 25 30 35 40 45 50

We do not take into account publications that without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

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GOST Copy

Xue R. et al. Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes // Cancer Cell. 2019. Vol. 35. No. 6. p. 932-947.e8.

GOST all authors (up to 50) Copy

Xue R., Lu C., Zhang C., Fujita M., Li R., Yan S., Ong C. J., Liao X., Gao Q., Sasagawa S., Li Y., Wang J., Guo H., Huang Q., Zhong Q., Tan J., QI L., Gong W., Hong Z., Li M., Zhao J., Peng T., Lu Y., Lim K. H. T., Boot A., Ono A., Chayama K., Zhang Z., Rozen S., Teh B. S., Wang X., Nakagawa H., Zeng M., Bai F., Wang J. Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes // Cancer Cell. 2019. Vol. 35. No. 6. p. 932-947.e8.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.ccell.2019.04.007

UR - https://doi.org/10.1016%2Fj.ccell.2019.04.007

TI - Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes

T2 - Cancer Cell

AU - Xue, Ruidong

AU - Lu, Chen

AU - Zhang, Chong

AU - Fujita, Masashi

AU - Li, Ruo-Yan

AU - Yan, Shu-mei

AU - Ong, Chin-Ann Johnny

AU - Liao, Xiwen

AU - Gao, Qiang

AU - Sasagawa, Shota

AU - Li, Yang

AU - Wang, Jincheng

AU - Guo, Hua

AU - Huang, Qi-tao

AU - Zhong, Qian

AU - Tan, Jing

AU - QI, LISHA

AU - Gong, Wenchen

AU - Hong, Zhixian

AU - Li, Meng

AU - Zhao, Jingmin

AU - Peng, Tao

AU - Lu, Yinying

AU - Lim, Kiat Hon Tony

AU - Boot, Arnoud

AU - Ono, Atushi

AU - Chayama, Kazuaki

AU - Zhang, Zemin

AU - Rozen, Steven G

AU - Teh, Bin S.

AU - Wang, Xin-Wei

AU - Nakagawa, Hidewaki

AU - Zeng, Musheng

AU - Bai, Fan

AU - Wang, Jiadong

PY - 2019

DA - 2019/06/01 00:00:00

PB - Elsevier

SP - 932-947.e8

IS - 6

VL - 35

PMID - 31130341

SN - 1535-6108

SN - 1878-3686

ER -

BibTex |

Cite this

BibTex Copy

@article{2019_Xue,

author = {Ruidong Xue and Chen Lu and Chong Zhang and Masashi Fujita and Ruo-Yan Li and Shu-mei Yan and Chin-Ann Johnny Ong and Xiwen Liao and Qiang Gao and Shota Sasagawa and Yang Li and Jincheng Wang and Hua Guo and Qi-tao Huang and Qian Zhong and Jing Tan and LISHA QI and Wenchen Gong and Zhixian Hong and Meng Li and Jingmin Zhao and Tao Peng and Yinying Lu and Kiat Hon Tony Lim and Arnoud Boot and Atushi Ono and Kazuaki Chayama and Zemin Zhang and Steven G Rozen and Bin S. Teh and Xin-Wei Wang and Hidewaki Nakagawa and Musheng Zeng and Fan Bai and Jiadong Wang},

title = {Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes},

journal = {Cancer Cell},

year = {2019},

volume = {35},

publisher = {Elsevier},

month = {jun},

url = {https://doi.org/10.1016%2Fj.ccell.2019.04.007},

number = {6},

pages = {932--947.e8},

doi = {10.1016/j.ccell.2019.04.007}

}

MLA

Cite this

MLA Copy

Xue, Ruidong, et al. “Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes.” Cancer Cell, vol. 35, no. 6, Jun. 2019, pp. 932-947.e8. https://doi.org/10.1016%2Fj.ccell.2019.04.007.

Found error?

Publisher

Elsevier

Journal

Cancer Cell

Quartile SCImago

Quartile WOS

Impact factor

50.3

ISSN

15356108 (Print)
18783686 (Electronic)