Cell, volume 165, issue 5, pages 1171-1181

Active Yeast Telomerase Shares Subunits with Ribonucleoproteins RNase P and RNase MRP

Lemieux Bruno ¹

Laterreur Nancy ¹

Perederina Anna ^{2, 3, 4, 5, 6, 7, 8}

Noël Jean-François ¹

Dubois Marie Line ⁹

Krasilnikov Andrey S. ^{2, 3, 4, 5, 6, 7, 8}

Wellinger Raymund J. ¹

Hide authors affiliations Show authors affiliations: 9 affiliations

Department of Microbiology and Infectious Diseases, Center of Excellence in RNA Biology, Université de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada |

Department of Biochemistry and Molecular Biology

Center for RNA Molecular Biology

⁴

PENNSYLVANIA STATE UNIVERSITY |

⁵

University Park |

⁶

⁷

16802

⁸

Usa |

⁹

Department of Anatomy and Cellular Biology,Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada |

Publication type: Journal Article

Publication date: 2016-05-06

Elsevier

Journal: Cell

Quartile SCImago

Quartile WOS

Impact factor: 64.5

ISSN: 00928674, 10974172

DOI: 10.1016/j.cell.2016.04.018

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PubMed ID: 27156450

General Biochemistry, Genetics and Molecular Biology

Abstract

Telomerase is the ribonucleoprotein enzyme that replenishes telomeric DNA and maintains genome integrity. Minimally, telomerase activity requires a templating RNA and a catalytic protein. Additional proteins are required for activity on telomeres in vivo. Here, we report that the Pop1, Pop6, and Pop7 proteins, known components of RNase P and RNase MRP, bind to yeast telomerase RNA and are essential constituents of the telomerase holoenzyme. Pop1/Pop6/Pop7 binding is specific and involves an RNA domain highly similar to a protein-binding domain in the RNAs of RNase P/MRP. The results also show that Pop1/Pop6/Pop7 function to maintain the essential components Est1 and Est2 on the RNA in vivo. Consistently, addition of Pop1 allows for telomerase activity reconstitution with wild-type telomerase RNA in vitro. Thus, the same chaperoning module has allowed the evolution of functionally and, remarkably, structurally distinct RNPs, telomerase, and RNases P/MRP from unrelated progenitor RNAs.

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Current Genetics	Current Genetics, 1, 1.33% Current Genetics 1 publication, 1.33%
BMC Biology	BMC Biology, 1, 1.33% BMC Biology 1 publication, 1.33%
Nature Structural and Molecular Biology	Nature Structural and Molecular Biology, 1, 1.33% Nature Structural and Molecular Biology 1 publication, 1.33%
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PLoS Genetics	PLoS Genetics, 1, 1.33% PLoS Genetics 1 publication, 1.33%
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Citations by publishers

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Elsevier	Elsevier, 15, 20% Elsevier 15 publications, 20%
Springer Nature	Springer Nature, 12, 16% Springer Nature 12 publications, 16%
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American Chemical Society (ACS)	American Chemical Society (ACS), 2, 2.67% American Chemical Society (ACS) 2 publications, 2.67%
Taylor & Francis	Taylor & Francis, 2, 2.67% Taylor & Francis 2 publications, 2.67%
Genetics Society of America	Genetics Society of America, 2, 2.67% Genetics Society of America 2 publications, 2.67%
Editions E D K	Editions E D K, 1, 1.33% Editions E D K 1 publication, 1.33%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 1, 1.33% Public Library of Science (PLoS) 1 publication, 1.33%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 1, 1.33% American Association for the Advancement of Science (AAAS) 1 publication, 1.33%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 1, 1.33% Proceedings of the National Academy of Sciences (PNAS) 1 publication, 1.33%
eLife Sciences Publications	eLife Sciences Publications, 1, 1.33% eLife Sciences Publications 1 publication, 1.33%
Annual Reviews	Annual Reviews, 1, 1.33% Annual Reviews 1 publication, 1.33%
American Society for Biochemistry and Molecular Biology	American Society for Biochemistry and Molecular Biology, 1, 1.33% American Society for Biochemistry and Molecular Biology 1 publication, 1.33%
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GOST Copy

Lemieux B. et al. Active Yeast Telomerase Shares Subunits with Ribonucleoproteins RNase P and RNase MRP // Cell. 2016. Vol. 165. No. 5. pp. 1171-1181.

GOST all authors (up to 50) Copy

Lemieux B., Laterreur N., Perederina A., Noël J., Dubois M. L., Krasilnikov A. S., Wellinger R. J. Active Yeast Telomerase Shares Subunits with Ribonucleoproteins RNase P and RNase MRP // Cell. 2016. Vol. 165. No. 5. pp. 1171-1181.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.cell.2016.04.018

UR - https://doi.org/10.1016%2Fj.cell.2016.04.018

TI - Active Yeast Telomerase Shares Subunits with Ribonucleoproteins RNase P and RNase MRP

T2 - Cell

AU - Lemieux, Bruno

AU - Laterreur, Nancy

AU - Perederina, Anna

AU - Noël, Jean-François

AU - Dubois, Marie Line

AU - Krasilnikov, Andrey S.

AU - Wellinger, Raymund J.

PY - 2016

DA - 2016/05/06 00:00:00

PB - Elsevier

SP - 1171-1181

IS - 5

VL - 165

PMID - 27156450

SN - 0092-8674

SN - 1097-4172

ER -

BibTex |

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BibTex Copy

@article{2016_Lemieux,

author = {Bruno Lemieux and Nancy Laterreur and Anna Perederina and Jean-François Noël and Marie Line Dubois and Andrey S. Krasilnikov and Raymund J. Wellinger},

title = {Active Yeast Telomerase Shares Subunits with Ribonucleoproteins RNase P and RNase MRP},

journal = {Cell},

year = {2016},

volume = {165},

publisher = {Elsevier},

month = {may},

url = {https://doi.org/10.1016%2Fj.cell.2016.04.018},

number = {5},

pages = {1171--1181},

doi = {10.1016/j.cell.2016.04.018}

}

MLA

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MLA Copy

Lemieux, Bruno, et al. “Active Yeast Telomerase Shares Subunits with Ribonucleoproteins RNase P and RNase MRP.” Cell, vol. 165, no. 5, May. 2016, pp. 1171-1181. https://doi.org/10.1016%2Fj.cell.2016.04.018.

Found error?

Publisher

Elsevier

Journal

Cell

Quartile SCImago

Quartile WOS

Impact factor

64.5

ISSN

00928674 (Print)
10974172 (Electronic)