Open Access

Cell Reports, volume 10, issue 4, pages 471-483

Global Reorganization of the Nuclear Landscape in Senescent Cells

Chandra Tamir ^{1, 2}

Ewels Philip ³

Schoenfelder Stefan ⁴

Furlan-Magaril Mayra ⁴

Wingett Steven W. ⁴

Kirschner Kristina ⁵

Thuret Jean-Yves ⁶

Andrews Simon ⁷

Fraser Peter ⁴

Reik W. ^{1, 2}

Hide authors affiliations Show authors affiliations: 7 affiliations

Epigenetics Programme, The Babraham Institute, Cambridge CB22 3AT, UK |

The Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK |

Epigenetics Programme, The Babraham Institute, Cambridge, CB22 3AT, UK. |

⁴

Nuclear Dynamics Programme, The Babraham Institute, Cambridge CB22 3AT, UK, |

⁵

Cambridge Institute for Medical Research University of Cambridge Cambridge CB2 0XY UK |

⁶

CEA, iBiTec-S, SBIGeM/CNRS FRE3377 I2BC/Université Paris-Sud, Gif-sur-Yvette 91191, France |

⁷

Bioinformatics Group, The Babraham Institute, Cambridge, CB22 3AT, UK |

Publication type: Journal Article

Publication date: 2015-02-01

Elsevier

Journal: Cell Reports

Quartile SCImago

Quartile WOS

Impact factor: 8.8

ISSN: 22111247

DOI: 10.1016/j.celrep.2014.12.055

Copy DOI

PubMed ID: 25640177

General Biochemistry, Genetics and Molecular Biology

Abstract

Summary Cellular senescence has been implicated in tumor suppression, development, and aging and is accompanied by large-scale chromatin rearrangements, forming senescence-associated heterochromatic foci (SAHF). However, how the chromatin is reorganized during SAHF formation is poorly understood. Furthermore, heterochromatin formation in senescence appears to contrast with loss of heterochromatin in Hutchinson-Gilford progeria. We mapped architectural changes in genome organization in cellular senescence using Hi-C. Unexpectedly, we find a dramatic sequence- and lamin-dependent loss of local interactions in heterochromatin. This change in local connectivity resolves the paradox of opposing chromatin changes in senescence and progeria. In addition, we observe a senescence-specific spatial clustering of heterochromatic regions, suggesting a unique second step required for SAHF formation. Comparison of embryonic stem cells (ESCs), somatic cells, and senescent cells shows a unidirectional loss in local chromatin connectivity, suggesting that senescence is an endpoint of the continuous nuclear remodelling process during differentiation.

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	1 2 3 4 5 6 7 8
Aging Cell	Aging Cell, 8, 3.14% Aging Cell 8 publications, 3.14%
Cells	Cells, 6, 2.35% Cells 6 publications, 2.35%
Frontiers in Cell and Developmental Biology	Frontiers in Cell and Developmental Biology, 6, 2.35% Frontiers in Cell and Developmental Biology 6 publications, 2.35%
Nature Communications	Nature Communications, 6, 2.35% Nature Communications 6 publications, 2.35%
Scientific Reports	Scientific Reports, 5, 1.96% Scientific Reports 5 publications, 1.96%
Cell Cycle	Cell Cycle, 5, 1.96% Cell Cycle 5 publications, 1.96%
Science advances	Science advances, 4, 1.57% Science advances 4 publications, 1.57%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 4, 1.57% International Journal of Molecular Sciences 4 publications, 1.57%
Genes	Genes, 4, 1.57% Genes 4 publications, 1.57%
Frontiers in Genetics	Frontiers in Genetics, 4, 1.57% Frontiers in Genetics 4 publications, 1.57%
Current Opinion in Cell Biology	Current Opinion in Cell Biology, 4, 1.57% Current Opinion in Cell Biology 4 publications, 1.57%
Seminars in Cell and Developmental Biology	Seminars in Cell and Developmental Biology, 4, 1.57% Seminars in Cell and Developmental Biology 4 publications, 1.57%
Trends in Genetics	Trends in Genetics, 4, 1.57% Trends in Genetics 4 publications, 1.57%
Nucleic Acids Research	Nucleic Acids Research, 4, 1.57% Nucleic Acids Research 4 publications, 1.57%
Genome Research	Genome Research, 4, 1.57% Genome Research 4 publications, 1.57%
Nucleus	Nucleus, 3, 1.18% Nucleus 3 publications, 1.18%
Aging	Aging, 3, 1.18% Aging 3 publications, 1.18%
Nature Cell Biology	Nature Cell Biology, 3, 1.18% Nature Cell Biology 3 publications, 1.18%
Trends in Cell Biology	Trends in Cell Biology, 3, 1.18% Trends in Cell Biology 3 publications, 1.18%
Cell	Cell, 3, 1.18% Cell 3 publications, 1.18%
Molecular Cell	Molecular Cell, 3, 1.18% Molecular Cell 3 publications, 1.18%
Mechanisms of Ageing and Development	Mechanisms of Ageing and Development, 3, 1.18% Mechanisms of Ageing and Development 3 publications, 1.18%
BioEssays	BioEssays, 3, 1.18% BioEssays 3 publications, 1.18%
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Cell Death and Differentiation	Cell Death and Differentiation, 2, 0.78% Cell Death and Differentiation 2 publications, 0.78%
Communications Biology	Communications Biology, 2, 0.78% Communications Biology 2 publications, 0.78%
Current Stem Cell Reports	Current Stem Cell Reports, 2, 0.78% Current Stem Cell Reports 2 publications, 0.78%
BMC Bioinformatics	BMC Bioinformatics, 2, 0.78% BMC Bioinformatics 2 publications, 0.78%
Seminars in Cancer Biology	Seminars in Cancer Biology, 2, 0.78% Seminars in Cancer Biology 2 publications, 0.78%
	1 2 3 4 5 6 7 8

Citations by publishers

	10 20 30 40 50 60
Elsevier	Elsevier, 55, 21.57% Elsevier 55 publications, 21.57%
Springer Nature	Springer Nature, 44, 17.25% Springer Nature 44 publications, 17.25%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 19, 7.45% Multidisciplinary Digital Publishing Institute (MDPI) 19 publications, 7.45%
Wiley	Wiley, 17, 6.67% Wiley 17 publications, 6.67%
Frontiers Media S.A.	Frontiers Media S.A., 13, 5.1% Frontiers Media S.A. 13 publications, 5.1%
Oxford University Press	Oxford University Press, 9, 3.53% Oxford University Press 9 publications, 3.53%
Taylor & Francis	Taylor & Francis, 8, 3.14% Taylor & Francis 8 publications, 3.14%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 6, 2.35% Cold Spring Harbor Laboratory 6 publications, 2.35%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 4, 1.57% American Association for the Advancement of Science (AAAS) 4 publications, 1.57%
Impact Journals	Impact Journals, 4, 1.57% Impact Journals 4 publications, 1.57%
Rockefeller University Press	Rockefeller University Press, 4, 1.57% Rockefeller University Press 4 publications, 1.57%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 3, 1.18% Public Library of Science (PLoS) 3 publications, 1.18%
The Company of Biologists	The Company of Biologists, 2, 0.78% The Company of Biologists 2 publications, 0.78%
Portland Press	Portland Press, 2, 0.78% Portland Press 2 publications, 0.78%
Naukova Dumka	Naukova Dumka, 2, 0.78% Naukova Dumka 2 publications, 0.78%
American Society for Clinical Investigation	American Society for Clinical Investigation, 1, 0.39% American Society for Clinical Investigation 1 publication, 0.39%
F1000 Research	F1000 Research, 1, 0.39% F1000 Research 1 publication, 0.39%
Mary Ann Liebert	Mary Ann Liebert, 1, 0.39% Mary Ann Liebert 1 publication, 0.39%
Social Science Electronic Publishing	Social Science Electronic Publishing, 1, 0.39% Social Science Electronic Publishing 1 publication, 0.39%
Biophysical Society	Biophysical Society, 1, 0.39% Biophysical Society 1 publication, 0.39%
Pleiades Publishing	Pleiades Publishing, 1, 0.39% Pleiades Publishing 1 publication, 0.39%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 1, 0.39% Proceedings of the National Academy of Sciences (PNAS) 1 publication, 0.39%
eLife Sciences Publications	eLife Sciences Publications, 1, 0.39% eLife Sciences Publications 1 publication, 0.39%
Annual Reviews	Annual Reviews, 1, 0.39% Annual Reviews 1 publication, 0.39%
AME Publishing Company	AME Publishing Company, 1, 0.39% AME Publishing Company 1 publication, 0.39%
	10 20 30 40 50 60

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Chandra T. et al. Global Reorganization of the Nuclear Landscape in Senescent Cells // Cell Reports. 2015. Vol. 10. No. 4. pp. 471-483.

GOST all authors (up to 50) Copy

Chandra T., Ewels P., Schoenfelder S., Furlan-Magaril M., Wingett S. W., Kirschner K., Thuret J., Andrews S., Fraser P., Reik W. Global Reorganization of the Nuclear Landscape in Senescent Cells // Cell Reports. 2015. Vol. 10. No. 4. pp. 471-483.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.celrep.2014.12.055

UR - https://doi.org/10.1016%2Fj.celrep.2014.12.055

TI - Global Reorganization of the Nuclear Landscape in Senescent Cells

T2 - Cell Reports

AU - Chandra, Tamir

AU - Ewels, Philip

AU - Schoenfelder, Stefan

AU - Furlan-Magaril, Mayra

AU - Wingett, Steven W.

AU - Kirschner, Kristina

AU - Thuret, Jean-Yves

AU - Andrews, Simon

AU - Fraser, Peter

AU - Reik, W.

PY - 2015

DA - 2015/02/01 00:00:00

PB - Elsevier

SP - 471-483

IS - 4

VL - 10

PMID - 25640177

SN - 2211-1247

ER -

BibTex |

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BibTex Copy

@article{2015_Chandra,

author = {Tamir Chandra and Philip Ewels and Stefan Schoenfelder and Mayra Furlan-Magaril and Steven W. Wingett and Kristina Kirschner and Jean-Yves Thuret and Simon Andrews and Peter Fraser and W. Reik},

title = {Global Reorganization of the Nuclear Landscape in Senescent Cells},

journal = {Cell Reports},

year = {2015},

volume = {10},

publisher = {Elsevier},

month = {feb},

url = {https://doi.org/10.1016%2Fj.celrep.2014.12.055},

number = {4},

pages = {471--483},

doi = {10.1016/j.celrep.2014.12.055}

}

MLA

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MLA Copy

Chandra, Tamir, et al. “Global Reorganization of the Nuclear Landscape in Senescent Cells.” Cell Reports, vol. 10, no. 4, Feb. 2015, pp. 471-483. https://doi.org/10.1016%2Fj.celrep.2014.12.055.

Found error?

Publisher

Elsevier

Journal

Cell Reports

Quartile SCImago

Quartile WOS

Impact factor

8.8

ISSN

22111247 (Print)