Open Access
Open access
Cell Reports, volume 22, issue 5, pages 1132-1140

The N Terminus of the OB Domain of Telomere Protein TPP1 Is Critical for Telomerase Action

Grill Sherilyn 1
Tesmer Valerie M. 1
Nandakumar Jayakrishnan 1
1
 
Department of Molecular Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
Publication typeJournal Article
Publication date2018-01-01
Journal: Cell Reports
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor8.8
ISSN22111247
General Biochemistry, Genetics and Molecular Biology
Abstract
Telomerase recruitment to telomeres and enzymatic processivity are mediated by TPP1, an essential component of telomere integrity and telomerase function. A surface on the OB domain of TPP1 called the TEL patch is critical for TPP1's telomerase-associated functions. Here, we identify a separate region in the N terminus of the OB domain (termed NOB) of TPP1 that, like the TEL patch, is essential for telomerase repeat addition processivity in vitro as well as telomerase recruitment to telomeres and telomere lengthening in cells. Although well-conserved among most mammalian TPP1 homologs, the NOB region in mice is distinct. Swapping the sequence of human NOB into mouse TPP1 allows it to stimulate human telomerase, qualifying NOB as an important determinant of species specificity for TPP1-telomerase interaction. Our studies show that TPP1 NOB is critical for telomerase function and demonstrate that the telomerase interaction surface on TPP1 is more elaborate than previously appreciated.

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GOST |
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GOST Copy
Grill S., Tesmer V. M., Nandakumar J. The N Terminus of the OB Domain of Telomere Protein TPP1 Is Critical for Telomerase Action // Cell Reports. 2018. Vol. 22. No. 5. pp. 1132-1140.
GOST all authors (up to 50) Copy
Grill S., Tesmer V. M., Nandakumar J. The N Terminus of the OB Domain of Telomere Protein TPP1 Is Critical for Telomerase Action // Cell Reports. 2018. Vol. 22. No. 5. pp. 1132-1140.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1016/j.celrep.2018.01.012
UR - https://doi.org/10.1016%2Fj.celrep.2018.01.012
TI - The N Terminus of the OB Domain of Telomere Protein TPP1 Is Critical for Telomerase Action
T2 - Cell Reports
AU - Grill, Sherilyn
AU - Tesmer, Valerie M.
AU - Nandakumar, Jayakrishnan
PY - 2018
DA - 2018/01/01 00:00:00
PB - Elsevier
SP - 1132-1140
IS - 5
VL - 22
PMID - 29386102
SN - 2211-1247
ER -
BibTex |
Cite this
BibTex Copy
@article{2018_Grill
author = {Sherilyn Grill and Valerie M. Tesmer and Jayakrishnan Nandakumar},
title = {The N Terminus of the OB Domain of Telomere Protein TPP1 Is Critical for Telomerase Action},
journal = {Cell Reports},
year = {2018},
volume = {22},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016%2Fj.celrep.2018.01.012},
number = {5},
pages = {1132--1140},
doi = {10.1016/j.celrep.2018.01.012}
}
MLA
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MLA Copy
Grill, Sherilyn, et al. “The N Terminus of the OB Domain of Telomere Protein TPP1 Is Critical for Telomerase Action.” Cell Reports, vol. 22, no. 5, Jan. 2018, pp. 1132-1140. https://doi.org/10.1016%2Fj.celrep.2018.01.012.
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