Open Access

Cell Reports, volume 24, issue 10, pages 2589-2595

Mitochondrial Trafficking and Processing of Telomerase RNA TERC

Cheng Ying ¹

Liu Peipei ¹

Zheng Qian ¹

Gao Ge ¹

Yuan Jiapei ¹

Wang Pengfeng ²

Huang Jinliang ¹

Xie Leiming ¹

Lu Xinping ¹

Tong Tanjun ^{2, 3}

Chen Jun ²

Lü Zhi ¹

Guan JiSong ¹

Wang Geng ¹

Hide authors affiliations Show authors affiliations: 3 affiliations

MOE Key laboratory of Bioinformatics, Cell Biology and Development Center, School of Life Sciences, Tsinghua University, Beijing, 100084, China. |

Peking University Research Center on Aging, Beijing 100191, China |

Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100191, China. |

Publication type: Journal Article

Publication date: 2018-09-04

Elsevier

Journal: Cell Reports

Quartile SCImago

Quartile WOS

Impact factor: 8.8

ISSN: 22111247

DOI: 10.1016/j.celrep.2018.08.003

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General Biochemistry, Genetics and Molecular Biology

Abstract

Mitochondrial dysfunctions play major roles in many diseases. However, how mitochondrial stresses are relayed to downstream responses remains unclear. Here we show that the RNA component of mammalian telomerase TERC is imported into mitochondria, processed to a shorter form TERC-53, and then exported back to the cytosol. We found that the import is regulated by PNPASE, and the processing is controlled by mitochondrion-localized RNASET2. Cytosolic TERC-53 levels respond to changes in mitochondrial functions but have no direct effect on these functions. These findings uncover a mitochondrial RNA trafficking pathway and provide a potential mechanism for mitochondria to relay their functional states to other cellular compartments.

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Citations by journals

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Frontiers in Cell and Developmental Biology	Frontiers in Cell and Developmental Biology, 4, 7.02% Frontiers in Cell and Developmental Biology 4 publications, 7.02%
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International Journal of Molecular Sciences	International Journal of Molecular Sciences, 4, 7.02% International Journal of Molecular Sciences 4 publications, 7.02%
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Molecular Therapy - Nucleic Acids	Molecular Therapy - Nucleic Acids, 2, 3.51% Molecular Therapy - Nucleic Acids 2 publications, 3.51%
Scientific Reports	Scientific Reports, 1, 1.75% Scientific Reports 1 publication, 1.75%
Philosophical Transactions of the Royal Society B: Biological Sciences	Philosophical Transactions of the Royal Society B: Biological Sciences, 1, 1.75% Philosophical Transactions of the Royal Society B: Biological Sciences 1 publication, 1.75%
Cancers	Cancers, 1, 1.75% Cancers 1 publication, 1.75%
Frontiers in Genetics	Frontiers in Genetics, 1, 1.75% Frontiers in Genetics 1 publication, 1.75%
Frontiers in Psychiatry	Frontiers in Psychiatry, 1, 1.75% Frontiers in Psychiatry 1 publication, 1.75%
Journal of Translational Medicine	Journal of Translational Medicine, 1, 1.75% Journal of Translational Medicine 1 publication, 1.75%
Molecular Neurobiology	Molecular Neurobiology, 1, 1.75% Molecular Neurobiology 1 publication, 1.75%
Protein and Cell	Protein and Cell, 1, 1.75% Protein and Cell 1 publication, 1.75%
Science China Life Sciences	Science China Life Sciences, 1, 1.75% Science China Life Sciences 1 publication, 1.75%
Ageing Research Reviews	Ageing Research Reviews, 1, 1.75% Ageing Research Reviews 1 publication, 1.75%
Computers in Biology and Medicine	Computers in Biology and Medicine, 1, 1.75% Computers in Biology and Medicine 1 publication, 1.75%
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Journal of Biological Chemistry	Journal of Biological Chemistry, 1, 1.75% Journal of Biological Chemistry 1 publication, 1.75%
Aging Cell	Aging Cell, 1, 1.75% Aging Cell 1 publication, 1.75%
BioEssays	BioEssays, 1, 1.75% BioEssays 1 publication, 1.75%
MedComm – Oncology	MedComm – Oncology, 1, 1.75% MedComm – Oncology 1 publication, 1.75%
ACS Biomaterials Science and Engineering	ACS Biomaterials Science and Engineering, 1, 1.75% ACS Biomaterials Science and Engineering 1 publication, 1.75%
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Citations by publishers

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Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 13, 22.81% Multidisciplinary Digital Publishing Institute (MDPI) 13 publications, 22.81%
Elsevier	Elsevier, 10, 17.54% Elsevier 10 publications, 17.54%
Springer Nature	Springer Nature, 9, 15.79% Springer Nature 9 publications, 15.79%
Frontiers Media S.A.	Frontiers Media S.A., 9, 15.79% Frontiers Media S.A. 9 publications, 15.79%
Wiley	Wiley, 3, 5.26% Wiley 3 publications, 5.26%
The Royal Society	The Royal Society, 1, 1.75% The Royal Society 1 publication, 1.75%
American Society for Biochemistry and Molecular Biology	American Society for Biochemistry and Molecular Biology, 1, 1.75% American Society for Biochemistry and Molecular Biology 1 publication, 1.75%
American Chemical Society (ACS)	American Chemical Society (ACS), 1, 1.75% American Chemical Society (ACS) 1 publication, 1.75%
Taylor & Francis	Taylor & Francis, 1, 1.75% Taylor & Francis 1 publication, 1.75%
American Society of Plant Biologists	American Society of Plant Biologists, 1, 1.75% American Society of Plant Biologists 1 publication, 1.75%
Oxford University Press	Oxford University Press, 1, 1.75% Oxford University Press 1 publication, 1.75%
Walter de Gruyter	Walter de Gruyter, 1, 1.75% Walter de Gruyter 1 publication, 1.75%
Hindawi Limited	Hindawi Limited, 1, 1.75% Hindawi Limited 1 publication, 1.75%
Spandidos Publications	Spandidos Publications, 1, 1.75% Spandidos Publications 1 publication, 1.75%
	2 4 6 8 10 12 14

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GOST |

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GOST Copy

Cheng Y. et al. Mitochondrial Trafficking and Processing of Telomerase RNA TERC // Cell Reports. 2018. Vol. 24. No. 10. pp. 2589-2595.

GOST all authors (up to 50) Copy

Cheng Y., Liu P., Zheng Q., Gao G., Yuan J., Wang P., Huang J., Xie L., Lu X., Tong T., Chen J., Lü Z., Guan J., Wang G. Mitochondrial Trafficking and Processing of Telomerase RNA TERC // Cell Reports. 2018. Vol. 24. No. 10. pp. 2589-2595.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.celrep.2018.08.003

UR - https://doi.org/10.1016%2Fj.celrep.2018.08.003

TI - Mitochondrial Trafficking and Processing of Telomerase RNA TERC

T2 - Cell Reports

AU - Cheng, Ying

AU - Liu, Peipei

AU - Zheng, Qian

AU - Gao, Ge

AU - Yuan, Jiapei

AU - Wang, Pengfeng

AU - Huang, Jinliang

AU - Xie, Leiming

AU - Lu, Xinping

AU - Tong, Tanjun

AU - Chen, Jun

AU - Lü, Zhi

AU - Guan, JiSong

AU - Wang, Geng

PY - 2018

DA - 2018/09/04 00:00:00

PB - Elsevier

SP - 2589-2595

IS - 10

VL - 24

SN - 2211-1247

ER -

BibTex |

Cite this

BibTex Copy

@article{2018_Cheng,

author = {Ying Cheng and Peipei Liu and Qian Zheng and Ge Gao and Jiapei Yuan and Pengfeng Wang and Jinliang Huang and Leiming Xie and Xinping Lu and Tanjun Tong and Jun Chen and Zhi Lü and JiSong Guan and Geng Wang},

title = {Mitochondrial Trafficking and Processing of Telomerase RNA TERC},

journal = {Cell Reports},

year = {2018},

volume = {24},

publisher = {Elsevier},

month = {sep},

url = {https://doi.org/10.1016%2Fj.celrep.2018.08.003},

number = {10},

pages = {2589--2595},

doi = {10.1016/j.celrep.2018.08.003}

}

MLA

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MLA Copy

Cheng, Ying, et al. “Mitochondrial Trafficking and Processing of Telomerase RNA TERC.” Cell Reports, vol. 24, no. 10, Sep. 2018, pp. 2589-2595. https://doi.org/10.1016%2Fj.celrep.2018.08.003.

Found error?

Publisher

Elsevier

Journal

Cell Reports

Quartile SCImago

Quartile WOS

Impact factor

8.8

ISSN

22111247 (Print)