Colloids and Surfaces A: Physicochemical and Engineering Aspects, volume 460, pages 225-235

Nanoprecipitation of polymers in a bad solvent

Lebouille J. G. J. L. ¹

Stepanyan R. ²

Slot J. J. M. ^{2, 3}

Cohen Stuart M.A. ⁴

Tuinier Remco ^{1, 5}

Hide authors affiliations Show authors affiliations: 5 affiliations

DSM ChemTech Center, Advanced Chemical Engineering Solutions (ACES), P.O. Box 18, 6160 MD Geleen, The Netherlands |

DSM Ahead, Materials Science Center, P.O. Box 18, 6160 MD Geleen, The Netherlands |

Department of Mathematics and Computer Science, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands |

⁴

Laboratory of Physical Chemistry and Colloid Science, Wageningen University , Dreijenplein 6, 6307 HB Wageningen, The Netherlands. |

⁵

Van’t Hoff Laboratory for Physical and Colloid Chemistry, Department of Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands |

Publication type: Journal Article

Publication date: 2014-10-01

Elsevier

Journal: Colloids and Surfaces A: Physicochemical and Engineering Aspects

Quartile SCImago

Quartile WOS

Impact factor: 5.2

ISSN: 09277757, 18734359

DOI: 10.1016/j.colsurfa.2013.11.045

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Colloid and Surface Chemistry

Abstract

Nanoparticles (NPs) composed of polymers are of great interest since they can add a functionality in many applications, ranging from food and pharma to plastics and electronics. A key factor that determines the functionality of NPs is their size. Nanoprecipitation [1] is a commonly used technique to prepare NPs. We have performed a combined experimental and theoretical study on the size of NPs formed by precipitation of polymers into a bad solvent in the presence of a stabilizing surfactant. We propose an extension of the theoretical framework put forward by Lannibois et al. [10] for nanoparticle formation via precipitation. Our theory is based upon a kinetic model for diffusion limited coalescence (DLC) in which the relevant transport and diffusion mechanisms are quantified. We find that the macroscopic mixing time and the diffusivity of the polymer and surfactant are the main parameters determining the final particle size. The theoretical result for the final size can be condensed into a single analytical expression. At given polymer concentration and mixing time, it follows that the smallest particles can be obtained in the excess of surfactant. This situation corresponds well to the experimentally used conditions. The mixing efficiency is predicted to have a profound influence on the final particle diameter: faster mixing results in smaller particles. The final particle size in the slow mixing regime, which is the typical situation in experiments, turns out to be independent of the molar mass of the polymer and scales as a power 1/3 with the initial polymer concentration. An increase of the surfactant molar mass is predicted to lead to larger particles, because of longer mixing time and lower surfactant mobility. We have performed systematic experimental investigations on nanoparticles formation using various systems but focused on polycaprolactone (PCL) polymers in acetone precipitated in aqueous solutions containing polyvinyl alcohol as surfactant. The PCL molar mass and concentration and mixing time were varied. We show that both our experimental results as well as literature data are in good agreement with our theoretical DLC predictions. This work therefore provides a solid framework for tailoring nanoparticles with a desired size.

By date By citations

Citations by journals

	1 2 3 4
Langmuir	Langmuir, 4, 8.33% Langmuir 4 publications, 8.33%
International Journal of Pharmaceutics	International Journal of Pharmaceutics, 3, 6.25% International Journal of Pharmaceutics 3 publications, 6.25%
Chemical Engineering Science	Chemical Engineering Science, 2, 4.17% Chemical Engineering Science 2 publications, 4.17%
Sensors and Actuators, B: Chemical	Sensors and Actuators, B: Chemical, 2, 4.17% Sensors and Actuators, B: Chemical 2 publications, 4.17%
Colloids and Surfaces A: Physicochemical and Engineering Aspects	Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2, 4.17% Colloids and Surfaces A: Physicochemical and Engineering Aspects 2 publications, 4.17%
Nanoscale	Nanoscale, 2, 4.17% Nanoscale 2 publications, 4.17%
Drug development & registration	Drug development & registration, 1, 2.08% Drug development & registration 1 publication, 2.08%
Polymers	Polymers, 1, 2.08% Polymers 1 publication, 2.08%
Nanomaterials	Nanomaterials, 1, 2.08% Nanomaterials 1 publication, 2.08%
Food Research International	Food Research International, 1, 2.08% Food Research International 1 publication, 2.08%
Materials Research Express	Materials Research Express, 1, 2.08% Materials Research Express 1 publication, 2.08%
Trends in Food Science and Technology	Trends in Food Science and Technology, 1, 2.08% Trends in Food Science and Technology 1 publication, 2.08%
Current Opinion in Colloid and Interface Science	Current Opinion in Colloid and Interface Science, 1, 2.08% Current Opinion in Colloid and Interface Science 1 publication, 2.08%
Carbohydrate Polymers	Carbohydrate Polymers, 1, 2.08% Carbohydrate Polymers 1 publication, 2.08%
Advances in Colloid and Interface Science	Advances in Colloid and Interface Science, 1, 2.08% Advances in Colloid and Interface Science 1 publication, 2.08%
ACS Sustainable Chemistry and Engineering	ACS Sustainable Chemistry and Engineering, 1, 2.08% ACS Sustainable Chemistry and Engineering 1 publication, 2.08%
Canadian Journal of Chemical Engineering	Canadian Journal of Chemical Engineering, 1, 2.08% Canadian Journal of Chemical Engineering 1 publication, 2.08%
Analytical Chemistry	Analytical Chemistry, 1, 2.08% Analytical Chemistry 1 publication, 2.08%
Nano Letters	Nano Letters, 1, 2.08% Nano Letters 1 publication, 2.08%
Industrial & Engineering Chemistry Research	Industrial & Engineering Chemistry Research, 1, 2.08% Industrial & Engineering Chemistry Research 1 publication, 2.08%
Biomacromolecules	Biomacromolecules, 1, 2.08% Biomacromolecules 1 publication, 2.08%
RSC Advances	RSC Advances, 1, 2.08% RSC Advances 1 publication, 2.08%
Chemical Communications	Chemical Communications, 1, 2.08% Chemical Communications 1 publication, 2.08%
Faraday Discussions	Faraday Discussions, 1, 2.08% Faraday Discussions 1 publication, 2.08%
Nanoscale Advances	Nanoscale Advances, 1, 2.08% Nanoscale Advances 1 publication, 2.08%
Drug Development and Industrial Pharmacy	Drug Development and Industrial Pharmacy, 1, 2.08% Drug Development and Industrial Pharmacy 1 publication, 2.08%
International Journal of Food Properties	International Journal of Food Properties, 1, 2.08% International Journal of Food Properties 1 publication, 2.08%
Biomaterials	Biomaterials, 1, 2.08% Biomaterials 1 publication, 2.08%
Methods in Molecular Biology	Methods in Molecular Biology, 1, 2.08% Methods in Molecular Biology 1 publication, 2.08%
	1 2 3 4

Citations by publishers

	2 4 6 8 10 12 14 16
Elsevier	Elsevier, 16, 33.33% Elsevier 16 publications, 33.33%
American Chemical Society (ACS)	American Chemical Society (ACS), 9, 18.75% American Chemical Society (ACS) 9 publications, 18.75%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 6, 12.5% Royal Society of Chemistry (RSC) 6 publications, 12.5%
Wiley	Wiley, 3, 6.25% Wiley 3 publications, 6.25%
Springer Nature	Springer Nature, 3, 6.25% Springer Nature 3 publications, 6.25%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 2, 4.17% Multidisciplinary Digital Publishing Institute (MDPI) 2 publications, 4.17%
Taylor & Francis	Taylor & Francis, 2, 4.17% Taylor & Francis 2 publications, 4.17%
Center of Pharmaceutical Analytics Ltd	Center of Pharmaceutical Analytics Ltd, 1, 2.08% Center of Pharmaceutical Analytics Ltd 1 publication, 2.08%
IOP Publishing	IOP Publishing, 1, 2.08% IOP Publishing 1 publication, 2.08%
	2 4 6 8 10 12 14 16

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Lebouille J. G. J. L. et al. Nanoprecipitation of polymers in a bad solvent // Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2014. Vol. 460. pp. 225-235.

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Lebouille J. G. J. L., Stepanyan R., Slot J. J. M., Cohen Stuart M., Tuinier R. Nanoprecipitation of polymers in a bad solvent // Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2014. Vol. 460. pp. 225-235.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.colsurfa.2013.11.045

UR - https://doi.org/10.1016%2Fj.colsurfa.2013.11.045

TI - Nanoprecipitation of polymers in a bad solvent

T2 - Colloids and Surfaces A: Physicochemical and Engineering Aspects

AU - Lebouille, J. G. J. L.

AU - Stepanyan, R.

AU - Slot, J. J. M.

AU - Cohen Stuart, M.A.

AU - Tuinier, Remco

PY - 2014

DA - 2014/10/01 00:00:00

PB - Elsevier

SP - 225-235

VL - 460

SN - 0927-7757

SN - 1873-4359

ER -

BibTex

Cite this

BibTex Copy

@article{2014_Lebouille,

author = {J. G. J. L. Lebouille and R. Stepanyan and J. J. M. Slot and M.A. Cohen Stuart and Remco Tuinier},

title = {Nanoprecipitation of polymers in a bad solvent},

journal = {Colloids and Surfaces A: Physicochemical and Engineering Aspects},

year = {2014},

volume = {460},

publisher = {Elsevier},

month = {oct},

url = {https://doi.org/10.1016%2Fj.colsurfa.2013.11.045},

pages = {225--235},

doi = {10.1016/j.colsurfa.2013.11.045}

}

Found error?

Publisher

Elsevier

Journal

Colloids and Surfaces A: Physicochemical and Engineering Aspects

Quartile SCImago

Quartile WOS

Impact factor

5.2

ISSN

09277757 (Print)
18734359 (Electronic)