Colloids and Surfaces A: Physicochemical and Engineering Aspects, volume 574, pages 44-51

Self-assembly of photosensitive and chemotherapeutic drugs for combined photodynamic-chemo cancer therapy with real-time tracing property

Wang Shengtao 1, 2
Li JH 3
Ye Zhou 4
Li Jieling 5
Wang Anhe 5
Hu Jing 4
Bai Shuo 5
Yin Jian 4
2
 
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China
3
 
Department of Gastroenterology, China-Japan Friendship Hospital, Beijing 100029, PR China
5
 
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering , Chinese Academy of Sciences , Beijing 100190 , PR China.
Publication typeJournal Article
Publication date2019-08-01
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor5.2
ISSN09277757, 18734359
Colloid and Surface Chemistry
Abstract
Herein, an amphipathic polymeric photosensitizer, designated as PEGylated distyryl boron dipyrromethenes with real-time tracing property, is synthesized as a kind of multifunctional carrier to load drugs for combined photodynamic-chemo therapy. The hydrophilic PEG side chains on the carriers prolong its blood circulation time and the self-assembly capacity of PEGylated distyryl boron dipyrromethenes effectively solves the problem of low drug loading efficiency and difficulty in drug release. Meanwhile, with the assistance of the photochemical internalization effect more carriers are taken up and accumulate in the cancer cells. Moreover, the autofluorescence of BODIPY can trace and visualize the carriers in cells or tissues and the damage of reactive oxygen species (ROS) to the multidrug resistance (MDR) transporter proteins can overcome MDR in cancer chemotherapy. The IC50 of PEGylated BODIPY is 250 μg/mL while the IC50 decreased to 100 μg/mL for Dox@PEGylated BODIPY. As shown in our experiment the self-carriers itself without loading other bioactive constituents can obviously inhibit the growth of cancer cells, and the therapeutic effect is improved after the loading of Dox, indicating the amphipathic polymeric photosensitizer with tracing and self-assembling properties a potential multifunctional cancer treatment platform.

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GOST Copy
Wang S. et al. Self-assembly of photosensitive and chemotherapeutic drugs for combined photodynamic-chemo cancer therapy with real-time tracing property // Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2019. Vol. 574. pp. 44-51.
GOST all authors (up to 50) Copy
Wang S., Li J., Ye Z., Li J., Wang A., Hu J., Bai S., Yin J. Self-assembly of photosensitive and chemotherapeutic drugs for combined photodynamic-chemo cancer therapy with real-time tracing property // Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2019. Vol. 574. pp. 44-51.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1016/j.colsurfa.2019.04.060
UR - https://doi.org/10.1016%2Fj.colsurfa.2019.04.060
TI - Self-assembly of photosensitive and chemotherapeutic drugs for combined photodynamic-chemo cancer therapy with real-time tracing property
T2 - Colloids and Surfaces A: Physicochemical and Engineering Aspects
AU - Wang, Shengtao
AU - Li, JH
AU - Ye, Zhou
AU - Li, Jieling
AU - Wang, Anhe
AU - Hu, Jing
AU - Bai, Shuo
AU - Yin, Jian
PY - 2019
DA - 2019/08/01 00:00:00
PB - Elsevier
SP - 44-51
VL - 574
SN - 0927-7757
SN - 1873-4359
ER -
BibTex
Cite this
BibTex Copy
@article{2019_Wang
author = {Shengtao Wang and JH Li and Zhou Ye and Jieling Li and Anhe Wang and Jing Hu and Shuo Bai and Jian Yin},
title = {Self-assembly of photosensitive and chemotherapeutic drugs for combined photodynamic-chemo cancer therapy with real-time tracing property},
journal = {Colloids and Surfaces A: Physicochemical and Engineering Aspects},
year = {2019},
volume = {574},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016%2Fj.colsurfa.2019.04.060},
pages = {44--51},
doi = {10.1016/j.colsurfa.2019.04.060}
}
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