Colloids and Surfaces B: Biointerfaces, volume 198, pages 111460
Multitherapy magnetic theranostic: Synthesis, characterization and in vitro evaluation of their performance.
Montiel Schneider María Gabriela
1
,
Favatela María Florencia
2
,
Muñoz Medina Guillermo Arturo
3
,
Fernández Van Raap Marcela Beatriz
3
,
Lassalle Verónica Leticia
2
1
INQUISUR, Departamento de Química, Universidad Nacional del Sur (UNS)-CONICET, Av. Alem 1253, 8000 Bahía Blanca, Buenos Aires, Argentina. Electronic address: gabriela.montiel@uns.edu.ar.
|
2
INQUISUR, Departamento de Química, Universidad Nacional del Sur (UNS)-CONICET, Av. Alem 1253, 8000 Bahía Blanca, Buenos Aires, Argentina
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3
Instituto de Física La Plata IFLP-CONICET, Departamento de Física, Universidad Nacional de La Plata, La Plata, Buenos Aires, Argentina.
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Publication type: Journal Article
Publication date: 2021-02-01
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.8
ISSN: 09277765, 18734367
Physical and Theoretical Chemistry
General Medicine
Colloid and Surface Chemistry
Biotechnology
Surfaces and Interfaces
Abstract
It is well known that iron oxide magnetic nanoparticles (IONPs) have many potential utilities in biomedicine due to their unique physicochemical properties. With the aim to obtain multifunctional nanoparticles with potential uses for therapy and diagnosis (nanotheranostics), IONPs were synthesized by hydrothermal synthesis assisted by mannose. Two synthetic pathways were evaluated in order to obtain IONPs with suitable properties for biomedical applications. The formulation Mag@Man/H1 presented the best characteristics in terms of size and stability. Mag@Man/H1 was evaluated as: a) drug carrier, b) antioxidant activity, c) magnetic hyperthermia, d) contrast agent for MRI. To evaluate the point a), morin, a natural flavonoid with several pharmaceutical activities, was loaded on the nanoparticles. A high percentage of drug loading was achieved. In point b) it was determined that the carrier itself possess a high activity which increased in morin loaded nanoparticles. Point c) magnetocalorimetric evaluation were carried out at several field conditions. A specific absorption rate value of 121.4 W/gFe was achieved at 52.4 kA/m and 260 kHz and 8.8 W/gFe at 4 kA/m and 100 kHz. Regarding contrast capacity (point d), the r1 value found was close to some contrast agent based on manganese. Although the measured r2 value was quite smaller than other iron oxides, the achieved effect was strong enough to produce negative contrast. From these studies, it was concluded that Mag@Man/H1 could act as a multifunctional nanoplatform for oncological diseases treatments.
Citations by journals
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ChemMedChem
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1 publication, 16.67%
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Citations by publishers
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1
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 16.67%
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Wiley
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Wiley
1 publication, 16.67%
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Springer Nature
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1 publication, 16.67%
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Elsevier
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1 publication, 16.67%
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SAGE
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SAGE
1 publication, 16.67%
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Montiel Schneider M. G. et al. Multitherapy magnetic theranostic: Synthesis, characterization and in vitro evaluation of their performance. // Colloids and Surfaces B: Biointerfaces. 2021. Vol. 198. p. 111460.
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Montiel Schneider M. G., Favatela M. F., Muñoz Medina G. A., Fernández Van Raap M. B., Lassalle V. L. Multitherapy magnetic theranostic: Synthesis, characterization and in vitro evaluation of their performance. // Colloids and Surfaces B: Biointerfaces. 2021. Vol. 198. p. 111460.
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TY - JOUR
DO - 10.1016/j.colsurfb.2020.111460
UR - https://doi.org/10.1016%2Fj.colsurfb.2020.111460
TI - Multitherapy magnetic theranostic: Synthesis, characterization and in vitro evaluation of their performance.
T2 - Colloids and Surfaces B: Biointerfaces
AU - Montiel Schneider, María Gabriela
AU - Favatela, María Florencia
AU - Muñoz Medina, Guillermo Arturo
AU - Fernández Van Raap, Marcela Beatriz
AU - Lassalle, Verónica Leticia
PY - 2021
DA - 2021/02/01 00:00:00
PB - Elsevier
SP - 111460
VL - 198
SN - 0927-7765
SN - 1873-4367
ER -
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@article{2021_Montiel Schneider,
author = {María Gabriela Montiel Schneider and María Florencia Favatela and Guillermo Arturo Muñoz Medina and Marcela Beatriz Fernández Van Raap and Verónica Leticia Lassalle},
title = {Multitherapy magnetic theranostic: Synthesis, characterization and in vitro evaluation of their performance.},
journal = {Colloids and Surfaces B: Biointerfaces},
year = {2021},
volume = {198},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016%2Fj.colsurfb.2020.111460},
pages = {111460},
doi = {10.1016/j.colsurfb.2020.111460}
}