Colloids and Surfaces B: Biointerfaces, volume 206, pages 111931
Non-magnetic shell coating of magnetic nanoparticles as key factor of toxicity for cancer cells in a low frequency alternating magnetic field
Iliasov Artem
1
,
Chernysheva A A
2
,
Garanina A. S.
1
,
Nizamov Timur R.
3, 4
,
Naumenko Victor
2
,
Vodopyanov Stepan S
3, 4
,
Abakumov M A
,
Majouga A G
,
Kan Y.
5
,
Metelkina O N
6
,
Schetinin I V
1
,
Pershina A G
,
Mogilnikov P S
1
,
Nikitin Aleksey A
3, 4
,
Pershina Alexandra G.
7, 8
,
Majouga Alexander G.
4, 9
,
Abakumov Maxim A.
10, 11
6
Chemical Biology of Carbohydrates, Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research, 66123 Saarbrücken, Germany
|
Publication type: Journal Article
Publication date: 2021-10-01
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.8
ISSN: 09277765, 18734367
Physical and Theoretical Chemistry
General Medicine
Colloid and Surface Chemistry
Biotechnology
Surfaces and Interfaces
Abstract
This work is devoted to studying the effects of non-magnetic shell coating on nanoparticles in a low frequency alternating magnetic field (LF AMF) on tumor cells in vitro . Two types of iron oxide nanoparticles with the same magnetic core with and without silica shells were synthesized. Nanoparticles with silica shells significantly decreased the viability of PC3 cancer cells in a low frequency alternating magnetic field according to the cytotoxicity test, unlike uncoated nanoparticles. We showed that cell death results from the intracellular membrane integrity failure, and the calcium ions concentration increase with the subsequent necrosis. Transmission electron microscopy images showed that the uncoated silica nanoparticles are primarily found in an aggregated form in cells. We believe that uncoated nanoparticles lose their colloidal stability in an acidic endosomal environment after internalization into the cell due to surface etching and the formation of aggregates. As a result, they encounter high endosomal macromolecular viscosity and become unable to rotate efficiently. We assume that effective rotation of nanoparticles causes cell death. In turn, silica shell coating increases nanoparticles stability, preventing aggregation in endosomes. Thus, we propose that the colloidal stability of magnetic nanoparticles inside cells is one of the key factors for effective magneto-mechanical actuation.
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Iliasov A. et al. Non-magnetic shell coating of magnetic nanoparticles as key factor of toxicity for cancer cells in a low frequency alternating magnetic field // Colloids and Surfaces B: Biointerfaces. 2021. Vol. 206. p. 111931.
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Nizamov T. R., Mogilnikov P. S., Pershina A. G., Abakumov M. A., Majouga A. G., Savchenko A. G., Schetinin I. V., Metelkina O. N., Kan Y., Chernysheva A. A., Nikitin A. A., Vodopyanov S. S., Garanina A. S., Naumenko V., Iliasov A., Nikitin A. A., Pershina A. G., Majouga A. G., Abakumov M. A. Non-magnetic shell coating of magnetic nanoparticles as key factor of toxicity for cancer cells in a low frequency alternating magnetic field // Colloids and Surfaces B: Biointerfaces. 2021. Vol. 206. p. 111931.
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TY - JOUR
DO - 10.1016/j.colsurfb.2021.111931
UR - https://doi.org/10.1016%2Fj.colsurfb.2021.111931
TI - Non-magnetic shell coating of magnetic nanoparticles as key factor of toxicity for cancer cells in a low frequency alternating magnetic field
T2 - Colloids and Surfaces B: Biointerfaces
AU - Iliasov, Artem
AU - Nizamov, Timur R.
AU - Naumenko, Victor
AU - Garanina, A. S.
AU - Vodopyanov, Stepan S
AU - Nikitin, A. A.
AU - Chernysheva, A A
AU - Kan, Y.
AU - Metelkina, O N
AU - Schetinin, I V
AU - Savchenko, Alexander G.
AU - Majouga, A G
AU - Abakumov, M A
AU - Pershina, A G
AU - Mogilnikov, P S
AU - Nikitin, Aleksey A
AU - Pershina, Alexandra G.
AU - Majouga, Alexander G.
AU - Abakumov, Maxim A.
PY - 2021
DA - 2021/10/01 00:00:00
PB - Elsevier
SP - 111931
VL - 206
SN - 0927-7765
SN - 1873-4367
ER -
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@article{2021_Iliasov,
author = {Artem Iliasov and Timur R. Nizamov and Victor Naumenko and A. S. Garanina and Stepan S Vodopyanov and A. A. Nikitin and A A Chernysheva and Y. Kan and O N Metelkina and I V Schetinin and Alexander G. Savchenko and A G Majouga and M A Abakumov and A G Pershina and P S Mogilnikov and Aleksey A Nikitin and Alexandra G. Pershina and Alexander G. Majouga and Maxim A. Abakumov},
title = {Non-magnetic shell coating of magnetic nanoparticles as key factor of toxicity for cancer cells in a low frequency alternating magnetic field},
journal = {Colloids and Surfaces B: Biointerfaces},
year = {2021},
volume = {206},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016%2Fj.colsurfb.2021.111931},
pages = {111931},
doi = {10.1016/j.colsurfb.2021.111931}
}