Cancer Treatment Reviews, volume 39, issue 5, pages 444-456
Novel anticancer therapeutics targeting telomerase
1
Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, Rockford, IL 61107 1822, USA
|
Publication type: Journal Article
Publication date: 2013-08-01
Journal:
Cancer Treatment Reviews
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 11.8
ISSN: 03057372
Oncology
General Medicine
Radiology, Nuclear Medicine and imaging
Abstract
Telomeres are protective caps at the ends of human chromosomes. Telomeres shorten with each successive cell division in normal human cells whereas, in tumors, they are continuously elongated by human telomerase reverse transcriptase (hTERT). Telomerase is overexpressed in 80-95% of cancers and is present in very low levels or is almost undetectable in normal cells. Because telomerase plays a pivotal role in cancer cell growth it may serve as an ideal target for anticancer therapeutics. Inhibition of telomerase may lead to a decrease of telomere length resulting in cell senescence and apoptosis in telomerase positive tumors. Several strategies of telomerase inhibition are reviewed, including small molecule inhibitors, antisense oligonucleotides, immunotherapies and gene therapies, targeting the hTERT or the ribonucleoprotein subunit hTER. G-quadruplex stabilizers, tankyrase and HSP90 inhibitors targeting telomere and telomerase assembly, and T-oligo approach are also covered. Based on this review, the most promising current telomerase targeting therapeutics are the antisense oligonucleotide inhibitor GRN163L and immunotherapies that use dendritic cells (GRVAC1), hTERT peptide (GV1001) or cryptic peptides (Vx-001). Most of these agents have entered phase I and II clinical trials in patients with various tumors, and have shown good response rates as evidenced by a reduction in tumor cell growth, increased overall disease survival, disease stabilization in advanced staged tumors and complete/partial responses. Most therapeutics have shown to be more effective when used in combination with standard therapies, resulting in concomitant telomere shortening and tumor mass shrinkage, as well as preventing tumor relapse and resistance to single agent therapy.
Citations by journals
|
2
4
6
8
10
12
|
|
|
Oncotarget
|
Oncotarget
11 publications, 4.8%
|
|
Molecules
|
Molecules
7 publications, 3.06%
|
|
Nucleic Acids Research
|
Nucleic Acids Research
4 publications, 1.75%
|
|
Cancers
|
Cancers
4 publications, 1.75%
|
|
Scientific Reports
|
Scientific Reports
4 publications, 1.75%
|
|
Journal of Medicinal Chemistry
|
Journal of Medicinal Chemistry
4 publications, 1.75%
|
|
RSC Advances
|
RSC Advances
4 publications, 1.75%
|
|
Molecular Medicine Reports
|
Molecular Medicine Reports
3 publications, 1.31%
|
|
Frontiers in Pharmacology
|
Frontiers in Pharmacology
3 publications, 1.31%
|
|
Cell Death and Disease
|
Cell Death and Disease
3 publications, 1.31%
|
|
European Journal of Medicinal Chemistry
|
European Journal of Medicinal Chemistry
3 publications, 1.31%
|
|
International Journal of Cancer
|
International Journal of Cancer
3 publications, 1.31%
|
|
Biopolymers and Cell
|
Biopolymers and Cell, 3, 1.31%
Biopolymers and Cell
3 publications, 1.31%
|
|
Biochemistry (Moscow)
|
Biochemistry (Moscow)
2 publications, 0.87%
|
|
Oncology Reports
|
Oncology Reports
2 publications, 0.87%
|
|
Nature Reviews Gastroenterology and Hepatology
|
Nature Reviews Gastroenterology and Hepatology
2 publications, 0.87%
|
|
Bioorganic and Medicinal Chemistry Letters
|
Bioorganic and Medicinal Chemistry Letters
2 publications, 0.87%
|
|
Biomeditsinskaya Khimiya
|
Biomeditsinskaya Khimiya
2 publications, 0.87%
|
|
PLoS ONE
|
PLoS ONE
2 publications, 0.87%
|
|
Bioorganic and Medicinal Chemistry
|
Bioorganic and Medicinal Chemistry
2 publications, 0.87%
|
|
Experimental and Molecular Pathology
|
Experimental and Molecular Pathology
2 publications, 0.87%
|
|
Cell
|
Cell
2 publications, 0.87%
|
|
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry
|
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry
2 publications, 0.87%
|
|
Nutrition and Cancer
|
Nutrition and Cancer
2 publications, 0.87%
|
|
Proceedings of the National Academy of Sciences of the United States of America
|
Proceedings of the National Academy of Sciences of the United States of America
2 publications, 0.87%
|
|
Biomolecular NMR Assignments
|
Biomolecular NMR Assignments
1 publication, 0.44%
|
|
Current Topics in Medicinal Chemistry
|
Current Topics in Medicinal Chemistry
1 publication, 0.44%
|
|
Endocrine-Related Cancer
|
Endocrine-Related Cancer
1 publication, 0.44%
|
|
Chemistry Letters
|
Chemistry Letters
1 publication, 0.44%
|
|
2
4
6
8
10
12
|
Citations by publishers
|
10
20
30
40
50
60
|
|
|
Elsevier
|
Elsevier
51 publications, 22.27%
|
|
Springer Nature
|
Springer Nature
36 publications, 15.72%
|
|
Wiley
|
Wiley
18 publications, 7.86%
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
17 publications, 7.42%
|
|
Impact Journals
|
Impact Journals
11 publications, 4.8%
|
|
Taylor & Francis
|
Taylor & Francis
10 publications, 4.37%
|
|
American Chemical Society (ACS)
|
American Chemical Society (ACS)
8 publications, 3.49%
|
|
Spandidos Publications
|
Spandidos Publications
6 publications, 2.62%
|
|
Pleiades Publishing
|
Pleiades Publishing
5 publications, 2.18%
|
|
Royal Society of Chemistry (RSC)
|
Royal Society of Chemistry (RSC)
5 publications, 2.18%
|
|
Oxford University Press
|
Oxford University Press
4 publications, 1.75%
|
|
SAGE
|
SAGE
4 publications, 1.75%
|
|
Frontiers Media S.A.
|
Frontiers Media S.A.
4 publications, 1.75%
|
|
Naukova Dumka
|
Naukova Dumka, 3, 1.31%
Naukova Dumka
3 publications, 1.31%
|
|
American Association for Cancer Research (AACR)
|
American Association for Cancer Research (AACR)
3 publications, 1.31%
|
|
V. N. Orekhovich Research Institute of Biomedical Chemistry
|
V. N. Orekhovich Research Institute of Biomedical Chemistry
2 publications, 0.87%
|
|
Public Library of Science (PLoS)
|
Public Library of Science (PLoS)
2 publications, 0.87%
|
|
American Society for Nutrition
|
American Society for Nutrition
2 publications, 0.87%
|
|
Proceedings of the National Academy of Sciences (PNAS)
|
Proceedings of the National Academy of Sciences (PNAS)
2 publications, 0.87%
|
|
Thieme
|
Thieme
2 publications, 0.87%
|
|
Bentham Science
|
Bentham Science
1 publication, 0.44%
|
|
Bioscientifica
|
Bioscientifica
1 publication, 0.44%
|
|
The Chemical Society of Japan
|
The Chemical Society of Japan
1 publication, 0.44%
|
|
Environmental Health Perspectives
|
Environmental Health Perspectives
1 publication, 0.44%
|
|
Future Medicine
|
Future Medicine
1 publication, 0.44%
|
|
The Royal Society
|
The Royal Society
1 publication, 0.44%
|
|
Wolters Kluwer Health
|
Wolters Kluwer Health
1 publication, 0.44%
|
|
Baishideng Publishing Group
|
Baishideng Publishing Group
1 publication, 0.44%
|
|
IOP Publishing
|
IOP Publishing
1 publication, 0.44%
|
|
10
20
30
40
50
60
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2013,2014,2015,2016,2017,2018,2019,2020,2021,2022,2023],"ids":[0,0,0,0,0,0,0,0,0,0,0],"codes":[0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["","","","","","","","","","",""],"datasets":[{"label":"Citations number","data":[12,33,26,31,32,21,15,21,13,15,10],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["5.24","14.41","11.35","13.54","13.97","9.17","6.55","9.17","5.68","6.55","4.37"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Oncotarget","Molecules","Nucleic Acids Research","Cancers","Scientific Reports","Journal of Medicinal Chemistry","RSC Advances","Molecular Medicine Reports","Frontiers in Pharmacology","Cell Death and Disease","European Journal of Medicinal Chemistry","International Journal of Cancer","Biopolymers and Cell","Biochemistry (Moscow)","Oncology Reports","Nature Reviews Gastroenterology and Hepatology","Bioorganic and Medicinal Chemistry Letters","Biomeditsinskaya Khimiya","PLoS ONE","Bioorganic and Medicinal Chemistry","Experimental and Molecular Pathology","Cell","Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry","Nutrition and Cancer","Proceedings of the National Academy of Sciences of the United States of America","Biomolecular NMR Assignments","Current Topics in Medicinal Chemistry","Endocrine-Related Cancer","Chemistry Letters"],"ids":[8484,1770,23904,22471,13767,3673,3100,4737,9788,25236,8171,24208,6631,2119,18785,13351,8828,13607,24963,1162,18388,16552,6894,3880,306,15938,3277,22561,6851],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/HY0CXgRt044tzIAB16PDvDzdHeKHGtSvlMH0yWf6_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/8zKfOwdd5XirYzTQfqwp7U8IEQc8ckIOjyYQSBkk_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/8zKfOwdd5XirYzTQfqwp7U8IEQc8ckIOjyYQSBkk_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/ORapGEvQagyY4uwGVkDHuIo7YUCJvWzb7YLElWuZ_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/mxFdPe9qujsfvfYfcN0QOclAiYORFb0xrRlwV8gs_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/gI2YSALZRdW7QrL82nSGMnE18gGeSacV0cvz6ORd_medium.webp","\/storage\/images\/resized\/ktSZPrGjOMvauY6mn7jk8bqo3Af0S6abv653w90B_medium.webp"],"datasets":[{"label":"","data":[11,7,4,4,4,4,4,3,3,3,3,3,3,2,2,2,2,2,2,2,2,2,2,2,2,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[4.8,3.06,1.75,1.75,1.75,1.75,1.75,1.31,1.31,1.31,1.31,1.31,1.31,0.87,0.87,0.87,0.87,0.87,0.87,0.87,0.87,0.87,0.87,0.87,0.87,0.44,0.44,0.44,0.44],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Elsevier","Springer Nature","Wiley","Multidisciplinary Digital Publishing Institute (MDPI)","Impact Journals","Taylor & Francis","American Chemical Society (ACS)","Spandidos Publications","Pleiades Publishing","Royal Society of Chemistry (RSC)","Oxford University Press","SAGE","Frontiers Media S.A.","Naukova Dumka","American Association for Cancer Research (AACR)","V. N. Orekhovich Research Institute of Biomedical Chemistry","Public Library of Science (PLoS)","American Society for Nutrition","Proceedings of the National Academy of Sciences (PNAS)","Thieme","Bentham Science","Bioscientifica","The Chemical Society of Japan","Environmental Health Perspectives","Future Medicine","The Royal Society","Wolters Kluwer Health","Baishideng Publishing Group","IOP Publishing"],"ids":[17,8,11,202,342,18,40,1097,101,123,19,31,208,2261,2286,9340,344,4369,162,135,39,7773,6950,8360,6949,259,32,7719,2075],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/HY0CXgRt044tzIAB16PDvDzdHeKHGtSvlMH0yWf6_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/8zKfOwdd5XirYzTQfqwp7U8IEQc8ckIOjyYQSBkk_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/ruydfaB80LDjlkYqsfOeUAZohOIODyq7bQzis5O7_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","","\/storage\/images\/resized\/cfuVw6XIq2mATDNJdXiose3W8qYbkmaVSpHoP8XL_medium.webp","\/storage\/images\/resized\/ORapGEvQagyY4uwGVkDHuIo7YUCJvWzb7YLElWuZ_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/JyeteN2yPY26qGWXzYgpUnxrPJug9G78ZQ0KXHWR_medium.webp","\/storage\/images\/resized\/mxFdPe9qujsfvfYfcN0QOclAiYORFb0xrRlwV8gs_medium.webp","\/storage\/images\/resized\/xqixcltwJYe6H8Uco2JbAFfIOzt7UNKH0OcPOPzO_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/gI2YSALZRdW7QrL82nSGMnE18gGeSacV0cvz6ORd_medium.webp","\/storage\/images\/resized\/ktSZPrGjOMvauY6mn7jk8bqo3Af0S6abv653w90B_medium.webp","\/storage\/images\/resized\/MIivvlLQFo5u9kfae4dJj89yPKKtYFbBg0R4AoGE_medium.webp","\/storage\/images\/resized\/AN2jnDN59NmKaS4CWLHAGstADL2DbnatQScsFA6C_medium.webp","\/storage\/images\/resized\/BHBStD1OkQqtKFRRjS5njgNe7bXCAEgaDQVK7GTA_medium.webp","\/storage\/images\/resized\/6QE8LXWrLpkoy5A2te6hw7who46GeCoTYIstuoAz_medium.webp","\/storage\/images\/resized\/bKOjgSt9mSGUD9fzKZyqcKSIgDCDSMd1ZWjJOZzx_medium.webp","\/storage\/images\/resized\/LsKy6OnmmmRGcAU6CZgWQvNiP1polbaSLNrN7zqj_medium.webp"],"datasets":[{"label":"","data":[51,36,18,17,11,10,8,6,5,5,4,4,4,3,3,2,2,2,2,2,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[22.27,15.72,7.86,7.42,4.8,4.37,3.49,2.62,2.18,2.18,1.75,1.75,1.75,1.31,1.31,0.87,0.87,0.87,0.87,0.87,0.44,0.44,0.44,0.44,0.44,0.44,0.44,0.44,0.44],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Ruden M., Puri N. Novel anticancer therapeutics targeting telomerase // Cancer Treatment Reviews. 2013. Vol. 39. No. 5. pp. 444-456.
GOST all authors (up to 50)
Copy
Ruden M., Puri N. Novel anticancer therapeutics targeting telomerase // Cancer Treatment Reviews. 2013. Vol. 39. No. 5. pp. 444-456.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.ctrv.2012.06.007
UR - https://doi.org/10.1016%2Fj.ctrv.2012.06.007
TI - Novel anticancer therapeutics targeting telomerase
T2 - Cancer Treatment Reviews
AU - Ruden, Maria
AU - Puri, Neelu
PY - 2013
DA - 2013/08/01 00:00:00
PB - Elsevier
SP - 444-456
IS - 5
VL - 39
SN - 0305-7372
ER -
Cite this
BibTex
Copy
@article{2013_Ruden,
author = {Maria Ruden and Neelu Puri},
title = {Novel anticancer therapeutics targeting telomerase},
journal = {Cancer Treatment Reviews},
year = {2013},
volume = {39},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016%2Fj.ctrv.2012.06.007},
number = {5},
pages = {444--456},
doi = {10.1016/j.ctrv.2012.06.007}
}
Cite this
MLA
Copy
Ruden, Maria, and Neelu Puri. “Novel anticancer therapeutics targeting telomerase.” Cancer Treatment Reviews, vol. 39, no. 5, Aug. 2013, pp. 444-456. https://doi.org/10.1016%2Fj.ctrv.2012.06.007.