DNA Repair, volume 12, issue 10, pages 800-810

Chromatin structure in double strand break repair

Gospodinov Anastas 1
Herceg Zdenko 2
1
 
Institute of Molecular Biology, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., 21, 1113 Sofia, Bulgaria
2
 
Epigenetics Group, International Agency for Research on Cancer (IARC), 150 Cours Albert Thomas, F-69008 Lyon, France
Publication typeJournal Article
Publication date2013-10-01
Journal: DNA Repair
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor3.8
ISSN15687864
Biochemistry
Molecular Biology
Cell Biology
Abstract
Cells are under constant assault by endogenous and environmental DNA damaging agents. DNA double strand breaks (DSBs) sever entire chromosomes and pose a major threat to genome integrity as a result of chromosomal fragment loss or chromosomal rearrangements. Exogenous factors such as ionizing radiation, crosslinking agents, and topoisomerase poisons, contribute to break formation. DSBs are associated with oxidative metabolism, form during the normal S phase, when replication forks collapse and are generated during physiological processes such as V(D)J recombination, yeast mating type switching and meiosis. It is estimated that in mammalian cells ∼10 DSBs per cell are formed daily. If left unrepaired DSBs can lead to cell death or deregulated growth, and cancer development. Cellular response to DSB damage includes mechanisms to halt the progression of the cell cycle and to restore the structure of the broken chromosome. Changes in chromatin adjacent to DNA break sites are instrumental to the DNA damage response (DDR) with two apparent ends: to control compaction and to bind repair and signaling molecules to the lesion. Here, we review the key findings related to each of these functions and examine their cross-talk.

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Gospodinov A., Herceg Z. Chromatin structure in double strand break repair // DNA Repair. 2013. Vol. 12. No. 10. pp. 800-810.
GOST all authors (up to 50) Copy
Gospodinov A., Herceg Z. Chromatin structure in double strand break repair // DNA Repair. 2013. Vol. 12. No. 10. pp. 800-810.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1016/j.dnarep.2013.07.006
UR - https://doi.org/10.1016%2Fj.dnarep.2013.07.006
TI - Chromatin structure in double strand break repair
T2 - DNA Repair
AU - Gospodinov, Anastas
AU - Herceg, Zdenko
PY - 2013
DA - 2013/10/01 00:00:00
PB - Elsevier
SP - 800-810
IS - 10
VL - 12
SN - 1568-7864
ER -
BibTex |
Cite this
BibTex Copy
@article{2013_Gospodinov
author = {Anastas Gospodinov and Zdenko Herceg},
title = {Chromatin structure in double strand break repair},
journal = {DNA Repair},
year = {2013},
volume = {12},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016%2Fj.dnarep.2013.07.006},
number = {10},
pages = {800--810},
doi = {10.1016/j.dnarep.2013.07.006}
}
MLA
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MLA Copy
Gospodinov, Anastas, and Zdenko Herceg. “Chromatin structure in double strand break repair.” DNA Repair, vol. 12, no. 10, Oct. 2013, pp. 800-810. https://doi.org/10.1016%2Fj.dnarep.2013.07.006.
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