Open Access

DNA Repair, volume 32, pages 10-16

The rise and fall of poly(ADP-ribose): An enzymatic perspective

Pascal John M. ¹

Ellenberger Tom ²

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Department of Biochemistry & Molecular Biology, Sydney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA |

Department of Biochemistry and Molecular Biophysics Washington University School of Medicine, Saint Louis MO, 63110, USA |

Publication type: Journal Article

Publication date: 2015-08-01

Elsevier

Journal: DNA Repair

Quartile SCImago

Quartile WOS

Impact factor: 3.8

ISSN: 15687864

DOI: 10.1016/j.dnarep.2015.04.008

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PubMed ID: 25963443

Biochemistry

Molecular Biology

Cell Biology

Abstract

Human cells respond to DNA damage with an acute and transient burst in production of poly(ADP-ribose), a posttranslational modification that expedites damage repair and plays a pivotal role in cell fate decisions. Poly(ADP-ribose) polymerases (PARPs) and glycohydrolase (PARG) are the key set of enzymes that orchestrate the rise and fall in cellular levels of poly(ADP-ribose). In this perspective, we focus on recent structural and mechanistic insights into the enzymes involved in poly(ADP-ribose) production and turnover, and we highlight important questions that remain to be answered.

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Citations by journals

	1 2 3 4 5 6
Nucleic Acids Research	Nucleic Acids Research, 6, 7.06% Nucleic Acids Research 6 publications, 7.06%
Scientific Reports	Scientific Reports, 4, 4.71% Scientific Reports 4 publications, 4.71%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 3, 3.53% International Journal of Molecular Sciences 3 publications, 3.53%
Cancers	Cancers, 3, 3.53% Cancers 3 publications, 3.53%
Frontiers in Oncology	Frontiers in Oncology, 3, 3.53% Frontiers in Oncology 3 publications, 3.53%
Molecular Cell	Molecular Cell, 3, 3.53% Molecular Cell 3 publications, 3.53%
Proceedings of the National Academy of Sciences of the United States of America	Proceedings of the National Academy of Sciences of the United States of America, 3, 3.53% Proceedings of the National Academy of Sciences of the United States of America 3 publications, 3.53%
Frontiers in Cell and Developmental Biology	Frontiers in Cell and Developmental Biology, 2, 2.35% Frontiers in Cell and Developmental Biology 2 publications, 2.35%
EMBO Molecular Medicine	EMBO Molecular Medicine, 2, 2.35% EMBO Molecular Medicine 2 publications, 2.35%
Oncogene	Oncogene, 2, 2.35% Oncogene 2 publications, 2.35%
Communications Biology	Communications Biology, 2, 2.35% Communications Biology 2 publications, 2.35%
Cancer Cell	Cancer Cell, 2, 2.35% Cancer Cell 2 publications, 2.35%
DNA Repair	DNA Repair, 2, 2.35% DNA Repair 2 publications, 2.35%
Molecular Biology	Molecular Biology, 2, 2.35% Molecular Biology 2 publications, 2.35%
Journal of Biological Chemistry	Journal of Biological Chemistry, 2, 2.35% Journal of Biological Chemistry 2 publications, 2.35%
Journal of Experimental Biology	Journal of Experimental Biology, 1, 1.18% Journal of Experimental Biology 1 publication, 1.18%
Oncotarget	Oncotarget, 1, 1.18% Oncotarget 1 publication, 1.18%
Aging	Aging, 1, 1.18% Aging 1 publication, 1.18%
Biochemical Journal	Biochemical Journal, 1, 1.18% Biochemical Journal 1 publication, 1.18%
Biochemical Society Transactions	Biochemical Society Transactions, 1, 1.18% Biochemical Society Transactions 1 publication, 1.18%
Frontiers in Microbiology	Frontiers in Microbiology, 1, 1.18% Frontiers in Microbiology 1 publication, 1.18%
Frontiers in Pharmacology	Frontiers in Pharmacology, 1, 1.18% Frontiers in Pharmacology 1 publication, 1.18%
Journal of Experimental and Clinical Cancer Research	Journal of Experimental and Clinical Cancer Research, 1, 1.18% Journal of Experimental and Clinical Cancer Research 1 publication, 1.18%
Nature Reviews Clinical Oncology	Nature Reviews Clinical Oncology, 1, 1.18% Nature Reviews Clinical Oncology 1 publication, 1.18%
Journal of Biomedical Science	Journal of Biomedical Science, 1, 1.18% Journal of Biomedical Science 1 publication, 1.18%
Nature Reviews Drug Discovery	Nature Reviews Drug Discovery, 1, 1.18% Nature Reviews Drug Discovery 1 publication, 1.18%
Nature Communications	Nature Communications, 1, 1.18% Nature Communications 1 publication, 1.18%
Pharmacology and Therapeutics	Pharmacology and Therapeutics, 1, 1.18% Pharmacology and Therapeutics 1 publication, 1.18%
Ageing Research Reviews	Ageing Research Reviews, 1, 1.18% Ageing Research Reviews 1 publication, 1.18%
	1 2 3 4 5 6

Citations by publishers

	2 4 6 8 10 12 14 16
Springer Nature	Springer Nature, 16, 18.82% Springer Nature 16 publications, 18.82%
Elsevier	Elsevier, 14, 16.47% Elsevier 14 publications, 16.47%
Frontiers Media S.A.	Frontiers Media S.A., 7, 8.24% Frontiers Media S.A. 7 publications, 8.24%
Oxford University Press	Oxford University Press, 7, 8.24% Oxford University Press 7 publications, 8.24%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 6, 7.06% Multidisciplinary Digital Publishing Institute (MDPI) 6 publications, 7.06%
Wiley	Wiley, 4, 4.71% Wiley 4 publications, 4.71%
EMBO press	EMBO press, 3, 3.53% EMBO press 3 publications, 3.53%
Pleiades Publishing	Pleiades Publishing, 3, 3.53% Pleiades Publishing 3 publications, 3.53%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 3, 3.53% Proceedings of the National Academy of Sciences (PNAS) 3 publications, 3.53%
Impact Journals	Impact Journals, 2, 2.35% Impact Journals 2 publications, 2.35%
Portland Press	Portland Press, 2, 2.35% Portland Press 2 publications, 2.35%
American Society for Biochemistry and Molecular Biology	American Society for Biochemistry and Molecular Biology, 2, 2.35% American Society for Biochemistry and Molecular Biology 2 publications, 2.35%
The Company of Biologists	The Company of Biologists, 1, 1.18% The Company of Biologists 1 publication, 1.18%
American Chemical Society (ACS)	American Chemical Society (ACS), 1, 1.18% American Chemical Society (ACS) 1 publication, 1.18%
Taylor & Francis	Taylor & Francis, 1, 1.18% Taylor & Francis 1 publication, 1.18%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 1, 1.18% American Association for the Advancement of Science (AAAS) 1 publication, 1.18%
eLife Sciences Publications	eLife Sciences Publications, 1, 1.18% eLife Sciences Publications 1 publication, 1.18%
Annual Reviews	Annual Reviews, 1, 1.18% Annual Reviews 1 publication, 1.18%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 1, 1.18% Cold Spring Harbor Laboratory 1 publication, 1.18%
	2 4 6 8 10 12 14 16

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Pascal J. M., Ellenberger T. The rise and fall of poly(ADP-ribose): An enzymatic perspective // DNA Repair. 2015. Vol. 32. pp. 10-16.

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Pascal J. M., Ellenberger T. The rise and fall of poly(ADP-ribose): An enzymatic perspective // DNA Repair. 2015. Vol. 32. pp. 10-16.

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Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.dnarep.2015.04.008

UR - https://doi.org/10.1016%2Fj.dnarep.2015.04.008

TI - The rise and fall of poly(ADP-ribose): An enzymatic perspective

T2 - DNA Repair

AU - Pascal, John M.

AU - Ellenberger, Tom

PY - 2015

DA - 2015/08/01 00:00:00

PB - Elsevier

SP - 10-16

VL - 32

PMID - 25963443

SN - 1568-7864

ER -

BibTex

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@article{2015_Pascal,

author = {John M. Pascal and Tom Ellenberger},

title = {The rise and fall of poly(ADP-ribose): An enzymatic perspective},

journal = {DNA Repair},

year = {2015},

volume = {32},

publisher = {Elsevier},

month = {aug},

url = {https://doi.org/10.1016%2Fj.dnarep.2015.04.008},

pages = {10--16},

doi = {10.1016/j.dnarep.2015.04.008}

}

Found error?

Publisher

Elsevier

Journal

DNA Repair

Quartile SCImago

Quartile WOS

Impact factor

3.8

ISSN

15687864 (Print)