Drug Discovery Today, volume 11, issue 23-24, pages 1054-1060

Novel fluorescent proteins for high-content screening

Wolff Michael L. ¹

Wiedenmann Jörg ²

Nienhaus G. Ulrich ^{3, 4}

Valler Martin ¹

Heilker Ralf ¹

Hide authors affiliations Show authors affiliations: 4 affiliations

Department of Lead Discovery, Boehringer Ingelheim Pharma GmbH and Co. KG, Birkendorfer Str.65, D-88397 Biberach, Germany |

Department of Zoology and Endocrinology, University of Ulm, D-89069 Ulm, Germany |

Department of bioPhysics, University of Ulm, D-89069 Ulm, Germany |

⁴

Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA |

Publication type: Journal Article

Publication date: 2006-12-01

Elsevier

Journal: Drug Discovery Today

Quartile SCImago

Quartile WOS

Impact factor: 7.4

ISSN: 13596446, 18785832

DOI: 10.1016/j.drudis.2006.09.005

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Drug Discovery

Pharmacology

Abstract

The development of fast microscopic imaging devices has enabled the application of automated fluorescence microscopy to pharmaceutical high-throughput drug-discovery assays, referred to as high-content screening (HCS). Initially, green fluorescent protein and its derivatives from Aequorea Victoria, and later anthozoan fluorescent proteins (FPs) have become potent tools as live-cell markers in HCS assays. We illustrate the broad applicability of classic and novel FPs to drug-discovery assays, giving example applications of the use of FPs in multiplexed imaging as fluorescent timers, photosensitizers and pulse-chase labels, and for robotically integrated compound testing.

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Citations by journals

	1
Molecular Imaging and Biology	Molecular Imaging and Biology, 1, 2.7% Molecular Imaging and Biology 1 publication, 2.7%
Journal of Cell Science	Journal of Cell Science, 1, 2.7% Journal of Cell Science 1 publication, 2.7%
Biosensors	Biosensors, 1, 2.7% Biosensors 1 publication, 2.7%
Nature Nanotechnology	Nature Nanotechnology, 1, 2.7% Nature Nanotechnology 1 publication, 2.7%
Cell Biochemistry and Biophysics	Cell Biochemistry and Biophysics, 1, 2.7% Cell Biochemistry and Biophysics 1 publication, 2.7%
Nature Reviews Cancer	Nature Reviews Cancer, 1, 2.7% Nature Reviews Cancer 1 publication, 2.7%
Journal of Chromatography A	Journal of Chromatography A, 1, 2.7% Journal of Chromatography A 1 publication, 2.7%
Journal of Oral Biology and Craniofacial Research	Journal of Oral Biology and Craniofacial Research, 1, 2.7% Journal of Oral Biology and Craniofacial Research 1 publication, 2.7%
SLAS Discovery	SLAS Discovery, 1, 2.7% SLAS Discovery 1 publication, 2.7%
Seminars in Cell and Developmental Biology	Seminars in Cell and Developmental Biology, 1, 2.7% Seminars in Cell and Developmental Biology 1 publication, 2.7%
Biochimica et Biophysica Acta - Proteins and Proteomics	Biochimica et Biophysica Acta - Proteins and Proteomics, 1, 2.7% Biochimica et Biophysica Acta - Proteins and Proteomics 1 publication, 2.7%
Current Opinion in Biotechnology	Current Opinion in Biotechnology, 1, 2.7% Current Opinion in Biotechnology 1 publication, 2.7%
Drug Discovery Today: Technologies	Drug Discovery Today: Technologies, 1, 2.7% Drug Discovery Today: Technologies 1 publication, 2.7%
European Journal of Medicinal Chemistry	European Journal of Medicinal Chemistry, 1, 2.7% European Journal of Medicinal Chemistry 1 publication, 2.7%
Current Protocols in Pharmacology	Current Protocols in Pharmacology, 1, 2.7% Current Protocols in Pharmacology 1 publication, 2.7%
Biotechnology Journal	Biotechnology Journal, 1, 2.7% Biotechnology Journal 1 publication, 2.7%
Analytical Chemistry	Analytical Chemistry, 1, 2.7% Analytical Chemistry 1 publication, 2.7%
Chemical Reviews	Chemical Reviews, 1, 2.7% Chemical Reviews 1 publication, 2.7%
Lab on a Chip	Lab on a Chip, 1, 2.7% Lab on a Chip 1 publication, 2.7%
Chemical Society Reviews	Chemical Society Reviews, 1, 2.7% Chemical Society Reviews 1 publication, 2.7%
Methods in Molecular Biology	Methods in Molecular Biology, 1, 2.7% Methods in Molecular Biology 1 publication, 2.7%
IEEE Transactions on Circuits and Systems I: Regular Papers	IEEE Transactions on Circuits and Systems I: Regular Papers, 1, 2.7% IEEE Transactions on Circuits and Systems I: Regular Papers 1 publication, 2.7%
Advances in Experimental Medicine and Biology	Advances in Experimental Medicine and Biology, 1, 2.7% Advances in Experimental Medicine and Biology 1 publication, 2.7%
Expert Opinion on Drug Discovery	Expert Opinion on Drug Discovery, 1, 2.7% Expert Opinion on Drug Discovery 1 publication, 2.7%
Moscow University Biological Sciences Bulletin	Moscow University Biological Sciences Bulletin, 1, 2.7% Moscow University Biological Sciences Bulletin 1 publication, 2.7%
Progress in Molecular Biology and Translational Science	Progress in Molecular Biology and Translational Science, 1, 2.7% Progress in Molecular Biology and Translational Science 1 publication, 2.7%
	1

Citations by publishers

	1 2 3 4 5 6 7 8
Elsevier	Elsevier, 8, 21.62% Elsevier 8 publications, 21.62%
Springer Nature	Springer Nature, 6, 16.22% Springer Nature 6 publications, 16.22%
Wiley	Wiley, 2, 5.41% Wiley 2 publications, 5.41%
American Chemical Society (ACS)	American Chemical Society (ACS), 2, 5.41% American Chemical Society (ACS) 2 publications, 5.41%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 2, 5.41% Royal Society of Chemistry (RSC) 2 publications, 5.41%
The Company of Biologists	The Company of Biologists, 1, 2.7% The Company of Biologists 1 publication, 2.7%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 1, 2.7% Multidisciplinary Digital Publishing Institute (MDPI) 1 publication, 2.7%
SAGE	SAGE, 1, 2.7% SAGE 1 publication, 2.7%
IEEE	IEEE, 1, 2.7% IEEE 1 publication, 2.7%
Taylor & Francis	Taylor & Francis, 1, 2.7% Taylor & Francis 1 publication, 2.7%
Pleiades Publishing	Pleiades Publishing, 1, 2.7% Pleiades Publishing 1 publication, 2.7%
	1 2 3 4 5 6 7 8

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Wolff M. L. et al. Novel fluorescent proteins for high-content screening // Drug Discovery Today. 2006. Vol. 11. No. 23-24. pp. 1054-1060.

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Wolff M. L., Wiedenmann J., Nienhaus G. U., Valler M., Heilker R. Novel fluorescent proteins for high-content screening // Drug Discovery Today. 2006. Vol. 11. No. 23-24. pp. 1054-1060.

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RIS Copy

TY - JOUR

DO - 10.1016/j.drudis.2006.09.005

UR - https://doi.org/10.1016%2Fj.drudis.2006.09.005

TI - Novel fluorescent proteins for high-content screening

T2 - Drug Discovery Today

AU - Wolff, Michael L.

AU - Wiedenmann, Jörg

AU - Nienhaus, G. Ulrich

AU - Valler, Martin

AU - Heilker, Ralf

PY - 2006

DA - 2006/12/01 00:00:00

PB - Elsevier

SP - 1054-1060

IS - 23-24

VL - 11

SN - 1359-6446

SN - 1878-5832

ER -

BibTex |

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@article{2006_Wolff,

author = {Michael L. Wolff and Jörg Wiedenmann and G. Ulrich Nienhaus and Martin Valler and Ralf Heilker},

title = {Novel fluorescent proteins for high-content screening},

journal = {Drug Discovery Today},

year = {2006},

volume = {11},

publisher = {Elsevier},

month = {dec},

url = {https://doi.org/10.1016%2Fj.drudis.2006.09.005},

number = {23-24},

pages = {1054--1060},

doi = {10.1016/j.drudis.2006.09.005}

}

MLA

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MLA Copy

Wolff, Michael L., et al. “Novel fluorescent proteins for high-content screening.” Drug Discovery Today, vol. 11, no. 23-24, Dec. 2006, pp. 1054-1060. https://doi.org/10.1016%2Fj.drudis.2006.09.005.

Found error?

Publisher

Elsevier

Journal

Drug Discovery Today

Quartile SCImago

Quartile WOS

Impact factor

7.4

ISSN

13596446 (Print)
18785832 (Electronic)