Open Access
European Journal of Medicinal Chemistry, volume 89, pages 743-816
Mannich bases in medicinal chemistry and drug design
1
Petru Poni Institute of Macromolecular Chemistry, Department of Inorganic Polymers, 41A Aleea Gr. Ghica Vodă, Iaşi 700487, Romania
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Publication type: Journal Article
Publication date: 2015-01-01
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 6.7
ISSN: 02235234, 17683254
PubMed ID:
25462280
Organic Chemistry
Drug Discovery
General Medicine
Pharmacology
Abstract
Abstract
The biological activity of Mannich bases, a structurally heterogeneous class of chemical compounds that are generated from various substrates through the introduction of an aminomethyl function by means of the Mannich reaction, is surveyed, with emphasis on the relationship between structure and biological activity. The review covers extensively the literature reports that have disclosed Mannich bases as anticancer and cytotoxic agents, or compounds with potential antibacterial and antifungal activity in the last decade. The most relevant studies on the activity of Mannich bases as antimycobacterial agents, antimalarials, or antiviral candidates have been included as well. The review contains also a thorough coverage of anticonvulsant, anti-inflammatory, analgesic and antioxidant activities of Mannich bases. In addition, several minor biological activities of Mannich bases, such as their ability to regulate blood pressure or inhibit platelet aggregation, their antiparasitic and anti-ulcer effects, as well as their use as agents for the treatment of mental disorders have been presented. The review gives in the end a brief overview of the potential of Mannich bases as inhibitors of various enzymes or ligands for several receptors.
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- We do not take into account publications that without a DOI.
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- Statistics recalculated weekly.
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GOST
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Roman G. Mannich bases in medicinal chemistry and drug design // European Journal of Medicinal Chemistry. 2015. Vol. 89. pp. 743-816.
GOST all authors (up to 50)
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Roman G. Mannich bases in medicinal chemistry and drug design // European Journal of Medicinal Chemistry. 2015. Vol. 89. pp. 743-816.
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TY - JOUR
DO - 10.1016/j.ejmech.2014.10.076
UR - https://doi.org/10.1016%2Fj.ejmech.2014.10.076
TI - Mannich bases in medicinal chemistry and drug design
T2 - European Journal of Medicinal Chemistry
AU - Roman, Gheorghe
PY - 2015
DA - 2015/01/01 00:00:00
PB - Elsevier
SP - 743-816
VL - 89
PMID - 25462280
SN - 0223-5234
SN - 1768-3254
ER -
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@article{2015_Roman,
author = {Gheorghe Roman},
title = {Mannich bases in medicinal chemistry and drug design},
journal = {European Journal of Medicinal Chemistry},
year = {2015},
volume = {89},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016%2Fj.ejmech.2014.10.076},
pages = {743--816},
doi = {10.1016/j.ejmech.2014.10.076}
}