European Journal of Medicinal Chemistry, volume 200, pages 112341

Contemporary approaches and future perspectives of antibacterial photodynamic therapy (aPDT) against methicillin-resistant Staphylococcus aureus (MRSA): A systematic review.

Dharmaratne Priyanga ¹

Sapugahawatte Dulmini Nanayakkara ²

Wang Baiyan ³

Chan Chung‐Han ⁴

Lau Kit-Man ⁵

Lau Clara ⁶

FUNG KWOK KIN ^{7, 8}

Ng Dennis Kp ⁹

Ip Margaret ^{10, 11}

Hide authors affiliations Show authors affiliations: 11 affiliations

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong (SAR), China. Electronic address: priyanga@cuhk.edu.hk. |

Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong (SAR), China. Electronic address: dulmini87@hotmail.com. |

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong (SAR), China. Electronic address: tinawang@cuhk.edu.hk. |

⁴

Institute of Chinese Medicine and State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants, The Chinese University of Hong Kong, China. Electronic address: benchan99@cuhk.edu.hk. |

⁵

⁶

⁷

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong (SAR), China |

⁸

CUHK-Zhejiang University Joint Laboratory on Natural Products and Toxicology Research, China. Electronic address: dkpn@cuhk.edu.hk. |

⁹

Department of Chemistry, Faculty of Science, The Chinese University of Hong Kong, Hong Kong (SAR), China |

¹⁰

Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong (SAR), China |

¹¹

Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China. Electronic address: margaretip@cuhk.edu.hk. |

Publication type: Journal Article

Publication date: 2020-08-01

Elsevier

Journal: European Journal of Medicinal Chemistry

Quartile SCImago

Quartile WOS

Impact factor: 6.7

ISSN: 02235234, 17683254

DOI: 10.1016/j.ejmech.2020.112341

Copy DOI

Organic Chemistry

Drug Discovery

General Medicine

Pharmacology

Abstract

The high prevalence of methicillin-resistant Staphylococcus aureus (MRSA) causing skin and soft tissue infections in both the community and healthcare settings challenges the limited options of effective antibiotics and motivates the search for alternative therapeutic solutions, such as antibacterial photodynamic therapy (aPDT). While many publications have described the promising anti-bacterial activities of PDT in vitro, its applications in vivo and in the clinic have been very limited. This limited availability may in part be due to variabilities in the selected photosensitizing agents (PS), the variable testing conditions used to examine anti-bacterial activities and their effectiveness in treating MRSA infections. We thus sought to systematically review and examine the evidence from existing studies on aPDT associated with MRSA and to critically appraise its current state of development and areas to be addressed in future studies. In 2018, we developed and registered a review protocol in the International Prospective Register of Systematic Reviews (PROSPERO) with registration No: CRD42018086736. Three bibliographical databases were consulted (PUBMED, MEDLINE, and EMBASE), and a total of 113 studies were included in this systematic review based on our eligibility criteria. Many variables, such as the use of a wide range of solvents, pre-irradiation times, irradiation times, light sources and light doses, have been used in the methods reported by researchers, which significantly affect the inter-study comparability and results. On another note, new approaches of linking immunoglobulin G (IgG), antibodies, efflux pump inhibitors, and bacteriophages with photosensitizers (PSs) and the incorporation of PSs into nano-scale delivery systems exert a direct effect on improving aPDT. Enhanced activities have also been achieved by optimizing the physicochemical properties of the PSs, such as the introduction of highly lipophilic, poly-cationic and site-specific modifications of the compounds. However, few in vivo studies (n = 17) have been conducted to translate aPDT into preclinical studies. We anticipate that further standardization of the experimental conditions and assessing the efficacy in vivo would allow this technology to be further applied in preclinical trials, so that aPDT would develop to become a sustainable, alternative therapeutic option against MRSA infection in the future.

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ACS applied materials & interfaces	ACS applied materials & interfaces, 3, 5% ACS applied materials & interfaces 3 publications, 5%
Molecules	Molecules, 2, 3.33% Molecules 2 publications, 3.33%
Dyes and Pigments	Dyes and Pigments, 2, 3.33% Dyes and Pigments 2 publications, 3.33%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 2, 3.33% International Journal of Molecular Sciences 2 publications, 3.33%
Photochemical and Photobiological Sciences	Photochemical and Photobiological Sciences, 2, 3.33% Photochemical and Photobiological Sciences 2 publications, 3.33%
Journal of Molecular Structure	Journal of Molecular Structure, 2, 3.33% Journal of Molecular Structure 2 publications, 3.33%
Journal of Photochemistry and Photobiology A: Chemistry	Journal of Photochemistry and Photobiology A: Chemistry, 1, 1.67% Journal of Photochemistry and Photobiology A: Chemistry 1 publication, 1.67%
Journal of Porphyrins and Phthalocyanines	Journal of Porphyrins and Phthalocyanines, 1, 1.67% Journal of Porphyrins and Phthalocyanines 1 publication, 1.67%
Materials	Materials, 1, 1.67% Materials 1 publication, 1.67%
Pharmaceutics	Pharmaceutics, 1, 1.67% Pharmaceutics 1 publication, 1.67%
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Drug Discovery Today	Drug Discovery Today, 1, 1.67% Drug Discovery Today 1 publication, 1.67%
PLoS ONE	PLoS ONE, 1, 1.67% PLoS ONE 1 publication, 1.67%
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Microorganisms	Microorganisms, 1, 1.67% Microorganisms 1 publication, 1.67%
Trends in Food Science and Technology	Trends in Food Science and Technology, 1, 1.67% Trends in Food Science and Technology 1 publication, 1.67%
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Photochemistry and Photobiology	Photochemistry and Photobiology, 1, 1.67% Photochemistry and Photobiology 1 publication, 1.67%
Advanced Materials	Advanced Materials, 1, 1.67% Advanced Materials 1 publication, 1.67%
ACS Applied Bio Materials	ACS Applied Bio Materials, 1, 1.67% ACS Applied Bio Materials 1 publication, 1.67%
Bioconjugate Chemistry	Bioconjugate Chemistry, 1, 1.67% Bioconjugate Chemistry 1 publication, 1.67%
New Journal of Chemistry	New Journal of Chemistry, 1, 1.67% New Journal of Chemistry 1 publication, 1.67%
Molecular Systems Design and Engineering	Molecular Systems Design and Engineering, 1, 1.67% Molecular Systems Design and Engineering 1 publication, 1.67%
RSC Advances	RSC Advances, 1, 1.67% RSC Advances 1 publication, 1.67%
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Citations by publishers

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Elsevier	Elsevier, 13, 21.67% Elsevier 13 publications, 21.67%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 9, 15% Multidisciplinary Digital Publishing Institute (MDPI) 9 publications, 15%
Wiley	Wiley, 8, 13.33% Wiley 8 publications, 13.33%
Springer Nature	Springer Nature, 7, 11.67% Springer Nature 7 publications, 11.67%
American Chemical Society (ACS)	American Chemical Society (ACS), 5, 8.33% American Chemical Society (ACS) 5 publications, 8.33%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 3, 5% Royal Society of Chemistry (RSC) 3 publications, 5%
Taylor & Francis	Taylor & Francis, 2, 3.33% Taylor & Francis 2 publications, 3.33%
World Scientific	World Scientific, 1, 1.67% World Scientific 1 publication, 1.67%
Frontiers Media S.A.	Frontiers Media S.A., 1, 1.67% Frontiers Media S.A. 1 publication, 1.67%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 1, 1.67% Public Library of Science (PLoS) 1 publication, 1.67%
Walter de Gruyter	Walter de Gruyter, 1, 1.67% Walter de Gruyter 1 publication, 1.67%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 1, 1.67% Proceedings of the National Academy of Sciences (PNAS) 1 publication, 1.67%
American Institute of Physics (AIP)	American Institute of Physics (AIP), 1, 1.67% American Institute of Physics (AIP) 1 publication, 1.67%
Ivanovo State University of Chemistry and Technology	Ivanovo State University of Chemistry and Technology, 1, 1.67% Ivanovo State University of Chemistry and Technology 1 publication, 1.67%
EDP Sciences	EDP Sciences, 1, 1.67% EDP Sciences 1 publication, 1.67%
	2 4 6 8 10 12 14

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Dharmaratne P. et al. Contemporary approaches and future perspectives of antibacterial photodynamic therapy (aPDT) against methicillin-resistant Staphylococcus aureus (MRSA): A systematic review. // European Journal of Medicinal Chemistry. 2020. Vol. 200. p. 112341.

GOST all authors (up to 50) Copy

Dharmaratne P., Sapugahawatte D. N., Wang B., Chan C., Lau K., Lau C., FUNG K. K., Ng D. K., Ip M. Contemporary approaches and future perspectives of antibacterial photodynamic therapy (aPDT) against methicillin-resistant Staphylococcus aureus (MRSA): A systematic review. // European Journal of Medicinal Chemistry. 2020. Vol. 200. p. 112341.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.ejmech.2020.112341

UR - https://doi.org/10.1016%2Fj.ejmech.2020.112341

TI - Contemporary approaches and future perspectives of antibacterial photodynamic therapy (aPDT) against methicillin-resistant Staphylococcus aureus (MRSA): A systematic review.

T2 - European Journal of Medicinal Chemistry

AU - Dharmaratne, Priyanga

AU - Sapugahawatte, Dulmini Nanayakkara

AU - Wang, Baiyan

AU - Chan, Chung‐Han

AU - Lau, Kit-Man

AU - Lau, Clara

AU - FUNG, KWOK KIN

AU - Ng, Dennis Kp

AU - Ip, Margaret

PY - 2020

DA - 2020/08/01 00:00:00

PB - Elsevier

SP - 112341

VL - 200

SN - 0223-5234

SN - 1768-3254

ER -

BibTex

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BibTex Copy

@article{2020_Dharmaratne,

author = {Priyanga Dharmaratne and Dulmini Nanayakkara Sapugahawatte and Baiyan Wang and Chung‐Han Chan and Kit-Man Lau and Clara Lau and KWOK KIN FUNG and Dennis Kp Ng and Margaret Ip},

title = {Contemporary approaches and future perspectives of antibacterial photodynamic therapy (aPDT) against methicillin-resistant Staphylococcus aureus (MRSA): A systematic review.},

journal = {European Journal of Medicinal Chemistry},

year = {2020},

volume = {200},

publisher = {Elsevier},

month = {aug},

url = {https://doi.org/10.1016%2Fj.ejmech.2020.112341},

pages = {112341},

doi = {10.1016/j.ejmech.2020.112341}

}

Found error?

Publisher

Elsevier

Journal

European Journal of Medicinal Chemistry

Quartile SCImago

Quartile WOS

Impact factor

6.7

ISSN

02235234 (Print)
17683254 (Electronic)