Experimental Neurology, volume 354, pages 114110
Theta and gamma hippocampal–neocortical oscillations during the episodic-like memory test: Impairment in epileptogenic rats
Publication type: Journal Article
Publication date: 2022-08-01
Journal:
Experimental Neurology
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.3
ISSN: 00144886, 10902430
Neurology
Developmental Neuroscience
Abstract
Cortical oscillations in different frequency bands have been shown to be intimately involved in exploration of environment and cognition. Here, the local field potentials in the hippocampus, the medial prefrontal cortex (mPFC), and the medial entorhinal cortex (mEC) were recorded simultaneously in rats during the execution of the episodic-like memory task. The power of theta (~4-10 Hz), slow gamma (~25-50 Hz), and fast gamma oscillations (~55-100 Hz) was analyzed in all structures examined. Particular attention was paid to the theta coherence between three mentioned structures. The modulation of the power of gamma rhythms by the phase of theta cycle during the execution of the episodic-like memory test by rats was also closely studied. Healthy rats and rats one month after kainate-induced status epilepticus (SE) were examined. Paroxysmal activity in the hippocampus (high amplitude interictal spikes), excessive excitability of animals, and the death of hippocampal and dentate granular cells in rats with kainate-evoked SE were observed, which indicated the development of seizure focus in the hippocampus (epileptogenesis). One month after SE, the rats exhibited a specific impairment of episodic memory for the what-where-when triad: unlike healthy rats, epileptogenic SE animals did not identify the objects during the test. This impairment was associated with the changes in the characteristics of theta and gamma rhythms and specific violation of theta coherence and theta/gamma coupling in these structures in comparison with the healthy animals. We believe that these disturbances in the cortical areas play a role in episodic memory dysfunction in kainate-treated animals. These findings can shed light on the mechanisms of cognitive deficit during epileptogenesis.
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Malkov A. et al. Theta and gamma hippocampal–neocortical oscillations during the episodic-like memory test: Impairment in epileptogenic rats // Experimental Neurology. 2022. Vol. 354. p. 114110.
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Malkov A., Sakr N., Latyshkova A., Kitchigina V. Theta and gamma hippocampal–neocortical oscillations during the episodic-like memory test: Impairment in epileptogenic rats // Experimental Neurology. 2022. Vol. 354. p. 114110.
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TY - JOUR
DO - 10.1016/j.expneurol.2022.114110
UR - https://doi.org/10.1016%2Fj.expneurol.2022.114110
TI - Theta and gamma hippocampal–neocortical oscillations during the episodic-like memory test: Impairment in epileptogenic rats
T2 - Experimental Neurology
AU - Malkov, Anton
AU - Sakr, Nawar
AU - Latyshkova, Alexandra
AU - Kitchigina, Valentina
PY - 2022
DA - 2022/08/01 00:00:00
PB - Elsevier
SP - 114110
VL - 354
SN - 0014-4886
SN - 1090-2430
ER -
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@article{2022_Malkov,
author = {Anton Malkov and Nawar Sakr and Alexandra Latyshkova and Valentina Kitchigina},
title = {Theta and gamma hippocampal–neocortical oscillations during the episodic-like memory test: Impairment in epileptogenic rats},
journal = {Experimental Neurology},
year = {2022},
volume = {354},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016%2Fj.expneurol.2022.114110},
pages = {114110},
doi = {10.1016/j.expneurol.2022.114110}
}
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