FEBS Letters, volume 589, issue 1, pages 59-67
The transcription factor Rap1p is required for tolerance to cell-wall perturbing agents and for cell-wall maintenance inSaccharomyces cerevisiae
Publication type: Journal Article
Publication date: 2014-12-03
Journal:
FEBS Letters
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 3.5
ISSN: 00145793, 18733468
Biochemistry
Molecular Biology
Cell Biology
Genetics
Structural Biology
Biophysics
Abstract
Yeast repressor activator protein (Rap1p) is involved in genomic stability and transcriptional regulation. We explored the function of Rap1p in yeast physiology using Rap1p truncation mutants. Our results revealed that the N‐terminal truncation of Rap1p (Rap1ΔN) leads to hypersensitivity towards elevated temperature and cell‐wall perturbing agents. Cell wall analysis showed an increase in the chitin and glucan content in Rap1ΔN cells as compared with wild type cells. Accordingly, mutant cells had a twofold thicker cell wall, as observed by electron microscopy. Furthermore, Rap1ΔN cells had increased levels of phosphorylated Slt2p, a MAP kinase of the cell wall integrity pathway. Mutant cells also had elevated levels of cell wall integrity response transcripts. Taken together, our findings suggest a connection between Rap1p and cell wall homeostasis.
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1 publication, 14.29%
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Citations by publishers
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Multidisciplinary Digital Publishing Institute (MDPI)
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2 publications, 28.57%
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Springer Nature
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1 publication, 14.29%
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1 publication, 14.29%
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Elsevier
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1 publication, 14.29%
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1 publication, 14.29%
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1 publication, 14.29%
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- We do not take into account publications that without a DOI.
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- Statistics recalculated weekly.
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Azad G. K. et al. The transcription factor Rap1p is required for tolerance to cell-wall perturbing agents and for cell-wall maintenance inSaccharomyces cerevisiae // FEBS Letters. 2014. Vol. 589. No. 1. pp. 59-67.
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Azad G. K., Singh V., Baranwal S., Thakare M. J., Tomar R. S. The transcription factor Rap1p is required for tolerance to cell-wall perturbing agents and for cell-wall maintenance inSaccharomyces cerevisiae // FEBS Letters. 2014. Vol. 589. No. 1. pp. 59-67.
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TY - JOUR
DO - 10.1016/j.febslet.2014.11.024
UR - https://doi.org/10.1016%2Fj.febslet.2014.11.024
TI - The transcription factor Rap1p is required for tolerance to cell-wall perturbing agents and for cell-wall maintenance inSaccharomyces cerevisiae
T2 - FEBS Letters
AU - Azad, Gajendra Kumar
AU - Singh, Vikash
AU - Baranwal, Shivani
AU - Thakare, Mayur Jankiram
AU - Tomar, Raghuvir S.
PY - 2014
DA - 2014/12/03 00:00:00
PB - Wiley
SP - 59-67
IS - 1
VL - 589
SN - 0014-5793
SN - 1873-3468
ER -
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@article{2014_Azad,
author = {Gajendra Kumar Azad and Vikash Singh and Shivani Baranwal and Mayur Jankiram Thakare and Raghuvir S. Tomar},
title = {The transcription factor Rap1p is required for tolerance to cell-wall perturbing agents and for cell-wall maintenance inSaccharomyces cerevisiae},
journal = {FEBS Letters},
year = {2014},
volume = {589},
publisher = {Wiley},
month = {dec},
url = {https://doi.org/10.1016%2Fj.febslet.2014.11.024},
number = {1},
pages = {59--67},
doi = {10.1016/j.febslet.2014.11.024}
}
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MLA
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Azad, Gajendra Kumar, et al. “The transcription factor Rap1p is required for tolerance to cell-wall perturbing agents and for cell-wall maintenance inSaccharomyces cerevisiae.” FEBS Letters, vol. 589, no. 1, Dec. 2014, pp. 59-67. https://doi.org/10.1016%2Fj.febslet.2014.11.024.