Free Radical Biology and Medicine, volume 174, pages 195-201
Brain region specificity in reactive oxygen species production and maintenance of redox balance
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Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London, WC1N 3BG, UK
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Publication type: Journal Article
Publication date: 2021-10-01
Journal:
Free Radical Biology and Medicine
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 7.4
ISSN: 08915849, 18734596
Biochemistry
Physiology (medical)
Abstract
The brain produces various reactive oxygen species in enzymatic and non-enzymatic reactions as a by-product of metabolism and/or for redox signaling. Effective antioxidant system in the brain cells maintains redox balance. However, neurons and glia from some brain regions are more vulnerable to oxidative stress in ischemia/reperfusion, epilepsy, and neurodegenerative disorders than the rest of the brain. Using fluorescent indicators in live cell imaging and confocal microscopy, we have measured the rate of cytosolic and mitochondrial reactive oxygen species production, lipid peroxidation, and glutathione levels in cortex, hippocampus, midbrain, brain stem and cerebellum in acute slices of rat brain. We have found that the basal rate of ROS production is at its highest in brain stem and cerebellum, and that it is mainly generated by glial cells. Activation of neurons and glia by glutamate and ATP led to maximal rates of ROS production in the midbrain compared to the rest of the brain. Mitochondrial ROS had only minor implication to the total ROS production with maximal values in the cortex and minimal in the midbrain. The basal rate of lipid peroxidation was higher in the midbrain and hippocampus, while the GSH level was similar in most brain regions with the lowest level in the midbrain. Thus, the rate of ROS production, lipid peroxidation and the level of GSH vary across brain regions. • The rates of cytosolic and mitochondrial ROS production are variable between brain regions. • The basic rate of lipid peroxidation and level of GSH are different in various brain regions. • The basal rate of ROS production is the highest in brain stem and cerebellum. • Maximal rate of ROS activated by ATP or glutamate is in the midbrain. • Mitochondrial ROS has minor implication to the total basal ROS production in all brain regions.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Vinokurov A. Y. et al. Brain region specificity in reactive oxygen species production and maintenance of redox balance // Free Radical Biology and Medicine. 2021. Vol. 174. pp. 195-201.
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Vinokurov A. Y., Stelmashchuk O., Ukolova P. A., Zherebtsov E. A., Abramov A. Y., Abramov A. Y. Brain region specificity in reactive oxygen species production and maintenance of redox balance // Free Radical Biology and Medicine. 2021. Vol. 174. pp. 195-201.
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TY - JOUR
DO - 10.1016/j.freeradbiomed.2021.08.014
UR - https://doi.org/10.1016%2Fj.freeradbiomed.2021.08.014
TI - Brain region specificity in reactive oxygen species production and maintenance of redox balance
T2 - Free Radical Biology and Medicine
AU - Vinokurov, Andrey Y.
AU - Stelmashchuk, Olga
AU - Ukolova, Polina A
AU - Zherebtsov, Evgeny A.
AU - Abramov, Andrey Y
AU - Abramov, Andrey Y.
PY - 2021
DA - 2021/10/01 00:00:00
PB - Elsevier
SP - 195-201
VL - 174
SN - 0891-5849
SN - 1873-4596
ER -
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@article{2021_Vinokurov,
author = {Andrey Y. Vinokurov and Olga Stelmashchuk and Polina A Ukolova and Evgeny A. Zherebtsov and Andrey Y Abramov and Andrey Y. Abramov},
title = {Brain region specificity in reactive oxygen species production and maintenance of redox balance},
journal = {Free Radical Biology and Medicine},
year = {2021},
volume = {174},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016%2Fj.freeradbiomed.2021.08.014},
pages = {195--201},
doi = {10.1016/j.freeradbiomed.2021.08.014}
}