Open Access
Genes and Diseases, volume 5, issue 2, pages 77-106
Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis
Feng Yixiao
1
,
Spezia Mia
2
,
Huang Shi-Feng
1
,
Yuan Chengfu
1, 3
,
ZENG ZONGYUE
1, 4
,
Zhang Linghuan
1, 5
,
JI XIAOJUAN
1, 5
,
Liu Wei Tang
1
,
Huang Bo
1, 4, 6
,
Luo Wenping
7, 8
,
Liu Bo
1
,
Lei Yan
1
,
Du Scott
1
,
Vuppalapati Akhila
1
,
Luu Hue H.
2
,
Haydon Rex C.
2
,
He Tong
2
,
Ren Guo-Sheng
1
Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA.
|
2
Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL, 60637, USA.
|
7
Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA
|
Publication type: Journal Article
Publication date: 2018-06-01
PubMed ID:
30258937
Biochemistry
Molecular Biology
Cell Biology
Genetics (clinical)
Abstract
As the most commonly occurring cancer in women worldwide, breast cancer poses a formidable public health challenge on a global scale. Breast cancer consists of a group of biologically and molecularly heterogeneous diseases originated from the breast. While the risk factors associated with this cancer varies with respect to other cancers, genetic predisposition, most notably mutations in BRCA1 or BRCA2 gene, is an important causative factor for this malignancy. Breast cancers can begin in different areas of the breast, such as the ducts, the lobules, or the tissue in between. Within the large group of diverse breast carcinomas, there are various denoted types of breast cancer based on their invasiveness relative to the primary tumor sites. It is important to distinguish between the various subtypes because they have different prognoses and treatment implications. As there are remarkable parallels between normal development and breast cancer progression at the molecular level, it has been postulated that breast cancer may be derived from mammary cancer stem cells. Normal breast development and mammary stem cells are regulated by several signaling pathways, such as estrogen receptors (ERs), HER2, and Wnt/β-catenin signaling pathways, which control stem cell proliferation, cell death, cell differentiation, and cell motility. Furthermore, emerging evidence indicates that epigenetic regulations and noncoding RNAs may play important roles in breast cancer development and may contribute to the heterogeneity and metastatic aspects of breast cancer, especially for triple-negative breast cancer. This review provides a comprehensive survey of the molecular, cellular and genetic aspects of breast cancer.
Citations by journals
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25
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5 publications, 0.79%
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5 publications, 0.79%
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4 publications, 0.63%
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F1000Research
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4 publications, 0.63%
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4 publications, 0.63%
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4 publications, 0.63%
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4 publications, 0.63%
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Oncotarget
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3 publications, 0.47%
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Diagnostics
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3 publications, 0.47%
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Pharmaceutics
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3 publications, 0.47%
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Frontiers in Genetics
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3 publications, 0.47%
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Frontiers in Immunology
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3 publications, 0.47%
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3 publications, 0.47%
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3 publications, 0.47%
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3 publications, 0.47%
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Citations by publishers
20
40
60
80
100
120
140
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Elsevier
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Elsevier
121 publications, 19.12%
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Springer Nature
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115 publications, 18.17%
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101 publications, 15.96%
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Wiley
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28 publications, 4.42%
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Frontiers Media S.A.
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22 publications, 3.48%
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Bentham Science
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17 publications, 2.69%
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Taylor & Francis
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15 publications, 2.37%
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Hindawi Limited
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Hindawi Limited
14 publications, 2.21%
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Spandidos Publications
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Spandidos Publications
10 publications, 1.58%
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7 publications, 1.11%
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Dove Medical Press
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7 publications, 1.11%
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SAGE
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SAGE
6 publications, 0.95%
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King Saud University
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King Saud University
6 publications, 0.95%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
6 publications, 0.95%
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Public Library of Science (PLoS)
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Public Library of Science (PLoS)
5 publications, 0.79%
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IOS Press
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IOS Press
5 publications, 0.79%
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Mary Ann Liebert
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Mary Ann Liebert
5 publications, 0.79%
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F1000 Research
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F1000 Research
4 publications, 0.63%
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Impact Journals
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Impact Journals
4 publications, 0.63%
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Oxford University Press
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Oxford University Press
4 publications, 0.63%
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Royal Society of Chemistry (RSC)
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Royal Society of Chemistry (RSC)
3 publications, 0.47%
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IEEE
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IEEE
2 publications, 0.32%
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Wolters Kluwer Health
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2 publications, 0.32%
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Baishideng Publishing Group
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2 publications, 0.32%
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2 publications, 0.32%
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Medknow Publications
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Medknow Publications, 2, 0.32%
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2 publications, 0.32%
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2 publications, 0.32%
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Hans Publishers
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Hans Publishers
2 publications, 0.32%
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AME Publishing Company
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AME Publishing Company
2 publications, 0.32%
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20
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140
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Feng Y. et al. Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis // Genes and Diseases. 2018. Vol. 5. No. 2. pp. 77-106.
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Feng Y., Spezia M., Huang S., Yuan C., ZENG Z., Zhang L., JI X., Liu W. T., Huang B., Luo W., Liu B., Lei Y., Du S., Vuppalapati A., Luu H. H., Haydon R. C., He T., Ren G. Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis // Genes and Diseases. 2018. Vol. 5. No. 2. pp. 77-106.
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TY - JOUR
DO - 10.1016/j.gendis.2018.05.001
UR - https://doi.org/10.1016%2Fj.gendis.2018.05.001
TI - Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis
T2 - Genes and Diseases
AU - Feng, Yixiao
AU - Spezia, Mia
AU - Huang, Shi-Feng
AU - Yuan, Chengfu
AU - ZENG, ZONGYUE
AU - Zhang, Linghuan
AU - JI, XIAOJUAN
AU - Liu, Wei Tang
AU - Huang, Bo
AU - Luo, Wenping
AU - Liu, Bo
AU - Lei, Yan
AU - Du, Scott
AU - Vuppalapati, Akhila
AU - Luu, Hue H.
AU - Haydon, Rex C.
AU - He, Tong
AU - Ren, Guo-Sheng
PY - 2018
DA - 2018/06/01 00:00:00
PB - Elsevier
SP - 77-106
IS - 2
VL - 5
PMID - 30258937
SN - 2352-3042
ER -
Cite this
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@article{2018_Feng,
author = {Yixiao Feng and Mia Spezia and Shi-Feng Huang and Chengfu Yuan and ZONGYUE ZENG and Linghuan Zhang and XIAOJUAN JI and Wei Tang Liu and Bo Huang and Wenping Luo and Bo Liu and Yan Lei and Scott Du and Akhila Vuppalapati and Hue H. Luu and Rex C. Haydon and Tong He and Guo-Sheng Ren},
title = {Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis},
journal = {Genes and Diseases},
year = {2018},
volume = {5},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016%2Fj.gendis.2018.05.001},
number = {2},
pages = {77--106},
doi = {10.1016/j.gendis.2018.05.001}
}
Cite this
MLA
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Feng, Yixiao, et al. “Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis.” Genes and Diseases, vol. 5, no. 2, Jun. 2018, pp. 77-106. https://doi.org/10.1016%2Fj.gendis.2018.05.001.