Open Access
Heliyon, volume 6, issue 4, pages e03768
A complex morphofunctional approach for zinc toxicity evaluation in rats
2
Univ. of Oulu (Finland)
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4
School of Medicine and Trinity Translational Medicine Institute, The University of Dublin, Trinity College, Ireland.
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Publication type: Journal Article
Publication date: 2020-04-21
PubMed ID:
32337380
Multidisciplinary
Abstract
Anthropogenic activity causes the introduction of zinc compounds into the biological cycle in mining and processing sites and its accumulation in organs and tissues, causing systemic toxicity. A cumulative effect of zinc is predominantly neurotoxic and it also affects the respiratory, cardiovascular and digestive systems. This study evaluates the effects of single-dose intragastric administration of 100 mg/kg zinc succinate on the structure and function of organs and tissues in male Wistar rats 1 month after treatment. The presented morphofunctional approach for the toxicity evaluation included the study of behavioral responses using the automated LaborasĀ® complex, fluorescent spectral analysis of the NADH and FAD activity and histological evaluation of animal organs and tissues. The results of the behavioral activity assessment showed a significant decrease in animals' motor activity, whereas the fluorescence spectra analysis demonstrated a decrease in coenzyme NADH without the reduction of FAD levels. We detected toxic and dystrophic changes in the cerebral cortex, heart, lungs and liver tissues. Our original multiparametric approach enables a comprehensive assessment of the long-term toxic effects of the metal salts such as zinc succinate, especially in the cerebral cortex at the doses much lower than the acute LD50 reported for the common zinc salts.
Citations by journals
1
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Nutrients
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Nutrients
1 publication, 33.33%
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Scientific Reports
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Scientific Reports
1 publication, 33.33%
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Food and Chemical Toxicology
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Food and Chemical Toxicology
1 publication, 33.33%
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1
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Citations by publishers
1
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 33.33%
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Springer Nature
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Springer Nature
1 publication, 33.33%
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Elsevier
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Elsevier
1 publication, 33.33%
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1
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Piavchenko G. et al. A complex morphofunctional approach for zinc toxicity evaluation in rats // Heliyon. 2020. Vol. 6. No. 4. p. e03768.
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Piavchenko G., Stelmashchuk O., Seryogina E., Zherebtsov E. A., Kuznetsova E., Dunaev A., Volkov Y., Kuznetsov S. G., Alekseev A. S., Dunaev A. V., Volkov Y. A complex morphofunctional approach for zinc toxicity evaluation in rats // Heliyon. 2020. Vol. 6. No. 4. p. e03768.
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TY - JOUR
DO - 10.1016/j.heliyon.2020.e03768
UR - https://doi.org/10.1016%2Fj.heliyon.2020.e03768
TI - A complex morphofunctional approach for zinc toxicity evaluation in rats
T2 - Heliyon
AU - Piavchenko, Gennadii
AU - Stelmashchuk, Olga
AU - Seryogina, Evgeniya
AU - Zherebtsov, Evgeny A.
AU - Kuznetsova, Elena
AU - Dunaev, Andrey
AU - Volkov, Yuri
AU - Kuznetsov, Sergey G
AU - Alekseev, Alexander S
AU - Dunaev, Andrey V.
AU - Volkov, Yuri
PY - 2020
DA - 2020/04/21 00:00:00
PB - Elsevier
SP - e03768
IS - 4
VL - 6
PMID - 32337380
SN - 2405-8440
ER -
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@article{2020_Piavchenko
author = {Gennadii Piavchenko and Olga Stelmashchuk and Evgeniya Seryogina and Evgeny A. Zherebtsov and Elena Kuznetsova and Andrey Dunaev and Yuri Volkov and Sergey G Kuznetsov and Alexander S Alekseev and Andrey V. Dunaev and Yuri Volkov},
title = {A complex morphofunctional approach for zinc toxicity evaluation in rats},
journal = {Heliyon},
year = {2020},
volume = {6},
publisher = {Elsevier},
month = {apr},
url = {https://doi.org/10.1016%2Fj.heliyon.2020.e03768},
number = {4},
pages = {e03768},
doi = {10.1016/j.heliyon.2020.e03768}
}
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MLA
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Piavchenko, Gennadii, et al. āA complex morphofunctional approach for zinc toxicity evaluation in rats.ā Heliyon, vol. 6, no. 4, Apr. 2020, p. e03768. https://doi.org/10.1016%2Fj.heliyon.2020.e03768.