Inorganica Chimica Acta, volume 505, pages 119482
Metal dipyrrin complexes as potential photosensitizers for photodynamic therapy
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Chimie ParisTech, PSL University, CNRS , Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology , 75005 Paris , France.
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Publication type: Journal Article
Publication date: 2020-05-01
Journal:
Inorganica Chimica Acta
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 2.8
ISSN: 00201693, 18733255
Materials Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Abstract
Over the last decades, the use of photodynamic therapy (PDT) for the treatment of various types of cancer as well fungal, viral and bacterial infections has received increasing attention. Despite its clinical success, the currently approved photosensitizers (PSs) are associated with poor water solubility, aggregation, low photostability and a long excretion time. To overcome these limitations, much research is devoted towards the development of PSs based on transition metal complexes. However, the majority of metals used for this purpose are rare and expensive. Therefore, it would be of high interest to develop effective PDT PSs based on cheap and abundant metals. In this article, the use of Cu(II) and Ni(II) dipyrrin complexes as potential PDT PSs against cancer is presented. As required for PDT applications, these complexes were found to have a strong absorption in the green spectrum and to be stable in an aqueous solution in the dark as well as upon light irradiation. Biological studies revealed that the complexes have a very low cytotoxic effect in the dark with a slight effect upon irradiation at 510 nm in human cervical carcinoma (HeLa) cells.
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- We do not take into account publications that without a DOI.
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- Statistics recalculated weekly.
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Karges J., BLACQUE O., Gasser G. Metal dipyrrin complexes as potential photosensitizers for photodynamic therapy // Inorganica Chimica Acta. 2020. Vol. 505. p. 119482.
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Karges J., BLACQUE O., Gasser G. Metal dipyrrin complexes as potential photosensitizers for photodynamic therapy // Inorganica Chimica Acta. 2020. Vol. 505. p. 119482.
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TY - JOUR
DO - 10.1016/j.ica.2020.119482
UR - https://doi.org/10.1016%2Fj.ica.2020.119482
TI - Metal dipyrrin complexes as potential photosensitizers for photodynamic therapy
T2 - Inorganica Chimica Acta
AU - Karges, Johannes
AU - BLACQUE, Olivier
AU - Gasser, Gilles
PY - 2020
DA - 2020/05/01 00:00:00
PB - Elsevier
SP - 119482
VL - 505
SN - 0020-1693
SN - 1873-3255
ER -
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@article{2020_Karges,
author = {Johannes Karges and Olivier BLACQUE and Gilles Gasser},
title = {Metal dipyrrin complexes as potential photosensitizers for photodynamic therapy},
journal = {Inorganica Chimica Acta},
year = {2020},
volume = {505},
publisher = {Elsevier},
month = {may},
url = {https://doi.org/10.1016%2Fj.ica.2020.119482},
pages = {119482},
doi = {10.1016/j.ica.2020.119482}
}