International Journal of Antimicrobial Agents, volume 39, issue 6, pages 478-485
Curing bacteria of antibiotic resistance: reverse antibiotics, a novel class of antibiotics in nature
Hiramatsu Keiichi
1
,
Igarashi Masayuki
2
,
Morimoto Yuh
1
,
Baba Tadashi
1
,
Umekita Maya
2
,
AKAMATSU Yuzuru
2
1
Department of Bacteriology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
|
2
Institute of Microbial Chemistry, Microbial Chemistry Research Foundation, Tokyo, Japan
|
Publication type: Journal Article
Publication date: 2012-06-01
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 10.8
ISSN: 09248579, 18727913
General Medicine
Microbiology (medical)
Infectious Diseases
Pharmacology (medical)
Abstract
By screening cultures of soil bacteria, we re-discovered an old antibiotic (nybomycin) as an antibiotic with a novel feature. Nybomycin is active against quinolone-resistant Staphylococcus aureus strains with mutated gyrA genes but not against those with intact gyrA genes against which quinolone antibiotics are effective. Nybomycin-resistant mutant strains were generated from a quinolone-resistant, nybomycin-susceptible, vancomycin-intermediate S. aureus (VISA) strain Mu 50. The mutants, occurring at an extremely low rate (<1 × 10(-11)/generation), were found to have their gyrA genes back-mutated and to have lost quinolone resistance. Here we describe nybomycin as the first member of a novel class of antibiotics designated 'reverse antibiotics'.
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1 publication, 2.33%
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1 publication, 2.33%
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Nature
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1 publication, 2.33%
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1 publication, 2.33%
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1 publication, 2.33%
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Citations by publishers
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4
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6
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6 publications, 13.95%
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5 publications, 11.63%
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4 publications, 9.3%
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1 publication, 2.33%
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Wiley
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1 publication, 2.33%
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Hindawi Limited
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1 publication, 2.33%
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1 publication, 2.33%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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MLA
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GOST
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Hiramatsu K. et al. Curing bacteria of antibiotic resistance: reverse antibiotics, a novel class of antibiotics in nature // International Journal of Antimicrobial Agents. 2012. Vol. 39. No. 6. pp. 478-485.
GOST all authors (up to 50)
Copy
Hiramatsu K., Igarashi M., Morimoto Y., Baba T., Umekita M., AKAMATSU Y. Curing bacteria of antibiotic resistance: reverse antibiotics, a novel class of antibiotics in nature // International Journal of Antimicrobial Agents. 2012. Vol. 39. No. 6. pp. 478-485.
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RIS
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TY - JOUR
DO - 10.1016/j.ijantimicag.2012.02.007
UR - https://doi.org/10.1016%2Fj.ijantimicag.2012.02.007
TI - Curing bacteria of antibiotic resistance: reverse antibiotics, a novel class of antibiotics in nature
T2 - International Journal of Antimicrobial Agents
AU - Hiramatsu, Keiichi
AU - Igarashi, Masayuki
AU - Morimoto, Yuh
AU - Baba, Tadashi
AU - Umekita, Maya
AU - AKAMATSU, Yuzuru
PY - 2012
DA - 2012/06/01 00:00:00
PB - Elsevier
SP - 478-485
IS - 6
VL - 39
SN - 0924-8579
SN - 1872-7913
ER -
Cite this
BibTex
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@article{2012_Hiramatsu,
author = {Keiichi Hiramatsu and Masayuki Igarashi and Yuh Morimoto and Tadashi Baba and Maya Umekita and Yuzuru AKAMATSU},
title = {Curing bacteria of antibiotic resistance: reverse antibiotics, a novel class of antibiotics in nature},
journal = {International Journal of Antimicrobial Agents},
year = {2012},
volume = {39},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016%2Fj.ijantimicag.2012.02.007},
number = {6},
pages = {478--485},
doi = {10.1016/j.ijantimicag.2012.02.007}
}
Cite this
MLA
Copy
Hiramatsu, Keiichi, et al. “Curing bacteria of antibiotic resistance: reverse antibiotics, a novel class of antibiotics in nature.” International Journal of Antimicrobial Agents, vol. 39, no. 6, Jun. 2012, pp. 478-485. https://doi.org/10.1016%2Fj.ijantimicag.2012.02.007.