International Journal of Biological Macromolecules, volume 166, pages 1121-1130
Monitoring the formation of insulin oligomers using a NIR emitting glucose-conjugated BODIPY dye.
Mora Aruna K
1
,
Murudkar Sushant
1
,
Shivran Neelam
2
,
Mula Soumyaditya
3, 4
,
Chattopadhyay Subrata
2
,
NATH S
5, 6
Publication type: Journal Article
Publication date: 2021-01-01
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 8.2
ISSN: 01418130, 18790003
Biochemistry
Molecular Biology
General Medicine
Structural Biology
Abstract
Protein oligomers, which are formed due to the aggregation of protein molecules under physiological stress, are neurotoxic and responsible for several neurological diseases. Early detection of protein oligomers is essential for the timely intervention in the associated diseases. Although several probes have been developed for the detection of insoluble matured protein fibrils, fluorescent probes with emission in the near infrared (NIR) region for probing protein oligomers are very rare. In the present study we have designed and synthesized a glucose-conjugated BODIPY dye with emission in the NIR spectral range. Our detailed studies show that the new probe is not only capable of detecting matured fibrils but can also probe the formation of oligomers from the native protein. The new probe shows a large increase in its emission intensity upon association with oligomers and matured fibrils. Hence, the present probe has a great potential for the in vivo imaging of protein oligomers and matured fibrils. Detailed spectroscopic properties of the new probes in molecular solvents have been performed to understand its oligomers- and fibril- sensing mechanism.
Citations by journals
1
2
3
|
|
International Journal of Biological Macromolecules
|
International Journal of Biological Macromolecules
3 publications, 25%
|
Molecules
|
Molecules
1 publication, 8.33%
|
Biological Trace Element Research
|
Biological Trace Element Research
1 publication, 8.33%
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Chemical Record
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Chemical Record
1 publication, 8.33%
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Organic and Biomolecular Chemistry
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Organic and Biomolecular Chemistry
1 publication, 8.33%
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Journal of Materials Chemistry B
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Journal of Materials Chemistry B
1 publication, 8.33%
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New Journal of Chemistry
|
New Journal of Chemistry
1 publication, 8.33%
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Talanta
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Talanta
1 publication, 8.33%
|
Indian Metallurgy
|
Indian Metallurgy
1 publication, 8.33%
|
TrAC - Trends in Analytical Chemistry
|
TrAC - Trends in Analytical Chemistry
1 publication, 8.33%
|
1
2
3
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Citations by publishers
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2
3
4
5
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Elsevier
|
Elsevier
5 publications, 41.67%
|
Royal Society of Chemistry (RSC)
|
Royal Society of Chemistry (RSC)
3 publications, 25%
|
Springer Nature
|
Springer Nature
2 publications, 16.67%
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 8.33%
|
Wiley
|
Wiley
1 publication, 8.33%
|
1
2
3
4
5
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Mora A. K. et al. Monitoring the formation of insulin oligomers using a NIR emitting glucose-conjugated BODIPY dye. // International Journal of Biological Macromolecules. 2021. Vol. 166. pp. 1121-1130.
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Mora A. K., Murudkar S., Shivran N., Mula S., Chattopadhyay S., NATH S. Monitoring the formation of insulin oligomers using a NIR emitting glucose-conjugated BODIPY dye. // International Journal of Biological Macromolecules. 2021. Vol. 166. pp. 1121-1130.
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TY - JOUR
DO - 10.1016/j.ijbiomac.2020.10.267
UR - https://doi.org/10.1016%2Fj.ijbiomac.2020.10.267
TI - Monitoring the formation of insulin oligomers using a NIR emitting glucose-conjugated BODIPY dye.
T2 - International Journal of Biological Macromolecules
AU - Mora, Aruna K
AU - Murudkar, Sushant
AU - Shivran, Neelam
AU - Mula, Soumyaditya
AU - Chattopadhyay, Subrata
AU - NATH, S
PY - 2021
DA - 2021/01/01 00:00:00
PB - Elsevier
SP - 1121-1130
VL - 166
SN - 0141-8130
SN - 1879-0003
ER -
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@article{2021_Mora,
author = {Aruna K Mora and Sushant Murudkar and Neelam Shivran and Soumyaditya Mula and Subrata Chattopadhyay and S NATH},
title = {Monitoring the formation of insulin oligomers using a NIR emitting glucose-conjugated BODIPY dye.},
journal = {International Journal of Biological Macromolecules},
year = {2021},
volume = {166},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016%2Fj.ijbiomac.2020.10.267},
pages = {1121--1130},
doi = {10.1016/j.ijbiomac.2020.10.267}
}