Open Access
International Journal of Pharmaceutics, volume 542, issue 1-2, pages 242-252
Current development in the formulations of non‐injection administration of paclitaxel
1
Department of Pharmaceutics, College of Pharmacy, Shandong University,Jinan 250012, China
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Publication type: Journal Article
Publication date: 2018-05-01
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.8
ISSN: 03785173, 18733476
Pharmaceutical Science
Abstract
&NA; Paclitaxel (PTX) belongs to a class of taxane anti‐tumor drug used for the clinic treatment of breast cancer, ovarian cancer, non‐small‐cell lung cancer, and so on. PTX has poor water solubility and oral bioavailability. It is generally administered via intravenous (i.v.) infusion. Traditional PTX injectable preparations contain Cremophor‐EL and ethanol to improve its solubility, which would result in adverse reactions like severe hypersensitivity, neutropenia, etc. Adverse reactions can be reduced only by complicated pretreatment with glucocorticoid and antihistamines drugs and followed by PTX slow infusion for three hours, which has brought significant inconvenience to the patients. Though, a new‐generation PTX formulation, Abraxane, free of Cremophor‐EL and ethanol, is still being administrated by frequent i.v. infusions and extremely expensive. Therefore, non‐injection administration of PTX is urgently needed to avoid the side effects as well as reduce inconvenience to the patients. Recently, a variety of non‐injection drug delivery systems (DDSs) of PTX have been developed. This review aims to discuss the progress of non‐injectable administration systems of PTX, including oral administration systems, vaginal administration systems, implantable DDSs, transdermal DDSs and intranasal administration for the future study and clinical applications.
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- Statistics recalculated weekly.
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GOST
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Du X. et al. Current development in the formulations of non‐injection administration of paclitaxel // International Journal of Pharmaceutics. 2018. Vol. 542. No. 1-2. pp. 242-252.
GOST all authors (up to 50)
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Du X., Khan A. R., Fu M., Ji J., Yu A., Zhai G. Current development in the formulations of non‐injection administration of paclitaxel // International Journal of Pharmaceutics. 2018. Vol. 542. No. 1-2. pp. 242-252.
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TY - JOUR
DO - 10.1016/j.ijpharm.2018.03.030
UR - https://doi.org/10.1016%2Fj.ijpharm.2018.03.030
TI - Current development in the formulations of non‐injection administration of paclitaxel
T2 - International Journal of Pharmaceutics
AU - Du, Xiyou
AU - Khan, Abdur R
AU - Fu, Manfei
AU - Ji, Jianbo
AU - Yu, Aihua
AU - Zhai, Guangxi
PY - 2018
DA - 2018/05/01 00:00:00
PB - Elsevier
SP - 242-252
IS - 1-2
VL - 542
SN - 0378-5173
SN - 1873-3476
ER -
Cite this
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@article{2018_Du,
author = {Xiyou Du and Abdur R Khan and Manfei Fu and Jianbo Ji and Aihua Yu and Guangxi Zhai},
title = {Current development in the formulations of non‐injection administration of paclitaxel},
journal = {International Journal of Pharmaceutics},
year = {2018},
volume = {542},
publisher = {Elsevier},
month = {may},
url = {https://doi.org/10.1016%2Fj.ijpharm.2018.03.030},
number = {1-2},
pages = {242--252},
doi = {10.1016/j.ijpharm.2018.03.030}
}
Cite this
MLA
Copy
Du, Xiyou, et al. “Current development in the formulations of non‐injection administration of paclitaxel.” International Journal of Pharmaceutics, vol. 542, no. 1-2, May. 2018, pp. 242-252. https://doi.org/10.1016%2Fj.ijpharm.2018.03.030.