The impact of immunomodulator compound from the group of substituted thiadiazines on the course of stress reaction.
Publication type: Journal Article
Publication date: 2015-04-01
scimago Q1
wos Q1
SJR: 1.239
CiteScore: 7.2
Impact factor: 4.7
ISSN: 15675769, 18781705
PubMed ID:
25737199
Pharmacology
Immunology
Immunology and Allergy
Abstract
A significant role of the stress response to many different diseases prompted a search for new specialized and non-specialized anti-stress agents. This study examines the effect of the compound L17 from the group of 5-phenyl substituted-6H-1,3,4-thiadiazine-2-amines, on the manifestations of the stress response. The authors used a standard model of immobilization stress, in which an animal was immobilized on its back for 6h a day. Parameters of the morphological and functional states of the organs studied were measured and biochemical and enzyme-immunoassays were carried out on the first and second days. This study reveals that the main mechanism by which the L17 compound mediates of its anti-stress was by activation of macrophages on the second day of the experiments and the inhibition of apoptosis in the thymus. The results enable us to suggest that the compound L17 does not improve resistance to stress; however, it does lower the reaction to stress.
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Total citations:
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Citations from 2024:
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GOST
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Sarapultsev A. et al. The impact of immunomodulator compound from the group of substituted thiadiazines on the course of stress reaction. // International Immunopharmacology. 2015. Vol. 25. No. 2. pp. 440-449.
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Sarapultsev A., Medvedeva S., Mukhlynina E. A., Brilliant S. A., Sidorova L., Danilova I. The impact of immunomodulator compound from the group of substituted thiadiazines on the course of stress reaction. // International Immunopharmacology. 2015. Vol. 25. No. 2. pp. 440-449.
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RIS
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TY - JOUR
DO - 10.1016/j.intimp.2015.02.024
UR - https://linkinghub.elsevier.com/retrieve/pii/S1567576915000715
TI - The impact of immunomodulator compound from the group of substituted thiadiazines on the course of stress reaction.
T2 - International Immunopharmacology
AU - Sarapultsev, Alexey
AU - Medvedeva, S.U.
AU - Mukhlynina, E A
AU - Brilliant, S A
AU - Sidorova, L.P.
AU - Danilova, I.G.
PY - 2015
DA - 2015/04/01
PB - Elsevier
SP - 440-449
IS - 2
VL - 25
PMID - 25737199
SN - 1567-5769
SN - 1878-1705
ER -
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BibTex (up to 50 authors)
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@article{2015_Sarapultsev,
author = {Alexey Sarapultsev and S.U. Medvedeva and E A Mukhlynina and S A Brilliant and L.P. Sidorova and I.G. Danilova},
title = {The impact of immunomodulator compound from the group of substituted thiadiazines on the course of stress reaction.},
journal = {International Immunopharmacology},
year = {2015},
volume = {25},
publisher = {Elsevier},
month = {apr},
url = {https://linkinghub.elsevier.com/retrieve/pii/S1567576915000715},
number = {2},
pages = {440--449},
doi = {10.1016/j.intimp.2015.02.024}
}
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MLA
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Sarapultsev, Alexey, et al. “The impact of immunomodulator compound from the group of substituted thiadiazines on the course of stress reaction..” International Immunopharmacology, vol. 25, no. 2, Apr. 2015, pp. 440-449. https://linkinghub.elsevier.com/retrieve/pii/S1567576915000715.