Journal of Biotechnology, volume 325, pages 25-34

Biocompatibility of magnetic nanoparticles coating with polycations using A549 cells.

Publication typeJournal Article
Publication date2021-01-01
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor4.1
ISSN01681656, 18734863
General Medicine
Applied Microbiology and Biotechnology
Biotechnology
Bioengineering
Abstract
• MNPs-PAH and MNPs-PDADMAC were non-toxic and had good biocompatibility, and can subsequently be used for in vivo studies. • AFM studies revealed the changes in cell surface roughness and adhesion associated with adherent polycation-modified MNPs. • Modification of cells with MNPs-PAH, MNPs-PDADMAC and MNPs-PEI did not interfere with formation of 3D cell spheroids. Fe 3 O 4 nanoparticles were obtained by chemical coprecipitation of iron chloride and sodium hydroxide. The morphology and sizes of the obtained nanoparticles were characterized using laser Doppler velocimetry, transmission electron and atomic force microscopy. Then the nanoparticles were stabilized by three polycations (polyethylenimine (PEI), poly(allylamine hydrochloride) (PAH), poly(diallyldimethylammonium chloride) (PDADMAC)) to increase their biocompatibility. The cytotoxicity of the obtained polymer-stabilized nanoparticles was studied using a human lung carcinoma cell line (A549). The biodistribution of nanoparticles stabilized by polycations in human lung carcinoma cells was analyzed by transmission electron microscopy, and the toxicity of nanomaterials was evaluated using toxicity tests and flow cytometry. As a result, the most biocompatible nanoparticle-biopolymer complex was identified. PAH stabilized magnetic nanoparticles demonstrated the best biocompatibility, and the PEI-magnetic nanoparticle complex was the most toxic.

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GOST Copy
Rozhina E. et al. Biocompatibility of magnetic nanoparticles coating with polycations using A549 cells. // Journal of Biotechnology. 2021. Vol. 325. pp. 25-34.
GOST all authors (up to 50) Copy
Rozhina E., Danilushkina A., Akhatova F., Fakhrullin R., Rozhin A., Batasheva S. Biocompatibility of magnetic nanoparticles coating with polycations using A549 cells. // Journal of Biotechnology. 2021. Vol. 325. pp. 25-34.
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TY - JOUR
DO - 10.1016/j.jbiotec.2020.12.003
UR - https://doi.org/10.1016%2Fj.jbiotec.2020.12.003
TI - Biocompatibility of magnetic nanoparticles coating with polycations using A549 cells.
T2 - Journal of Biotechnology
AU - Rozhina, Elvira
AU - Danilushkina, Anna
AU - Akhatova, Farida
AU - Fakhrullin, R.F.
AU - Rozhin, Artem
AU - Batasheva, Svetlana
PY - 2021
DA - 2021/01/01 00:00:00
PB - Elsevier
SP - 25-34
VL - 325
SN - 0168-1656
SN - 1873-4863
ER -
BibTex
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BibTex Copy
@article{2021_Rozhina
author = {Elvira Rozhina and Anna Danilushkina and Farida Akhatova and R.F. Fakhrullin and Artem Rozhin and Svetlana Batasheva},
title = {Biocompatibility of magnetic nanoparticles coating with polycations using A549 cells.},
journal = {Journal of Biotechnology},
year = {2021},
volume = {325},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016%2Fj.jbiotec.2020.12.003},
pages = {25--34},
doi = {10.1016/j.jbiotec.2020.12.003}
}
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