Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, volume 855, issue 2, pages 211-219
HPLC method for the determination of carboplatin and paclitaxel with cremophorEL in an amphiphilic polymer matrix.
Publication type: Journal Article
Publication date: 2007-08-01
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 3
ISSN: 15700232, 1873376X
Biochemistry
General Medicine
Cell Biology
Clinical Biochemistry
Analytical Chemistry
Abstract
Simple and rapid reversed phase HPLC methods for individual as well as simultaneous analysis of paclitaxel and carboplatin with cremophorEL (CrEL) in an amphiphilic polymer matrix were developed. Different analytical performance parameters such as linearity, accuracy, precision, specificity, limit of detection (LOD) and limit of quantification (LOQ) were determined according to ICH guidelines. All the analytical methods were developed by reverse phase HPLC on C-18 column with a mobile phase comprising of water-acetonitrile run on isocratic mode for the analysis of carboplatin and gradient mode for individual analysis of paclitaxel and for simultaneous analysis of the two drugs at a flow rate of 1 ml/min at 227 nm. The proposed methods for independent analysis of the drugs elute out carboplatin in 4.3 min and paclitaxel in 10.5 min while in simultaneous analysis carboplatin shows R(t) at 4 min and paclitaxel at 18 min with a continuous run for 17 more minutes to elute out CrEL. These methods were found to be specific as none of the components of the media, i.e. polymer, CrEL and buffer interfered with the drug peaks. The linearity of the calibration curves for each analyte in the desired concentration range was found to be good (r(2)>0.9995). The methods were accurate and precise with recoveries ranging from 98 to 101% for each drug and relative standard deviation (%RSD) <2%. Peaks corresponding to each of the drug showed positive value for the minimum peak purity index over the entire range of integrated chromatographic peak thus indicating the purity of the peaks. Stability analysis of the two drugs revealed that the drugs remain stable during the period of study.
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1 publication, 2.94%
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Citations by publishers
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Elsevier
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8 publications, 23.53%
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Springer Nature
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1 publication, 2.94%
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1 publication, 2.94%
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Shenyang Pharmaceutical University
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Shenyang Pharmaceutical University, 1, 2.94%
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1 publication, 2.94%
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1 publication, 2.94%
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1 publication, 2.94%
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Oxford University Press
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Oxford University Press
1 publication, 2.94%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Mittal A., Chitkara D., Kumar N. HPLC method for the determination of carboplatin and paclitaxel with cremophorEL in an amphiphilic polymer matrix. // Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 2007. Vol. 855. No. 2. pp. 211-219.
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Mittal A., Chitkara D., Kumar N. HPLC method for the determination of carboplatin and paclitaxel with cremophorEL in an amphiphilic polymer matrix. // Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 2007. Vol. 855. No. 2. pp. 211-219.
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TY - JOUR
DO - 10.1016/j.jchromb.2007.05.005
UR - https://doi.org/10.1016%2Fj.jchromb.2007.05.005
TI - HPLC method for the determination of carboplatin and paclitaxel with cremophorEL in an amphiphilic polymer matrix.
T2 - Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
AU - Mittal, Anupama
AU - Chitkara, Deepak
AU - Kumar, Neeraj
PY - 2007
DA - 2007/08/01 00:00:00
PB - Elsevier
SP - 211-219
IS - 2
VL - 855
SN - 1570-0232
SN - 1873-376X
ER -
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@article{2007_Mittal,
author = {Anupama Mittal and Deepak Chitkara and Neeraj Kumar},
title = {HPLC method for the determination of carboplatin and paclitaxel with cremophorEL in an amphiphilic polymer matrix.},
journal = {Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences},
year = {2007},
volume = {855},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016%2Fj.jchromb.2007.05.005},
number = {2},
pages = {211--219},
doi = {10.1016/j.jchromb.2007.05.005}
}
Cite this
MLA
Copy
Mittal, Anupama, et al. “HPLC method for the determination of carboplatin and paclitaxel with cremophorEL in an amphiphilic polymer matrix..” Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 855, no. 2, Aug. 2007, pp. 211-219. https://doi.org/10.1016%2Fj.jchromb.2007.05.005.