Open Access
Journal of Colloid and Interface Science, volume 537, pages 132-141
Synthesis and characterization of bacteriochlorin loaded magnetic nanoparticles (MNP) for personalized MRI guided photosensitizers delivery to tumor
Semkina A S
2
,
Naumenko Victor
3
,
Plotnikova E A
4
,
Melnikov Pavel A
2
,
Abakumova T O
5
,
Yakubovskaya R. I.
4
,
Mironov Andrey F
1
,
Majouga Alexander G.
6, 7
,
Grin Mikhail A.
1
,
Чехонин В. П.
2
,
2
7
Miusskaya sq. 9 125047 Moscow Russia
|
Publication type: Journal Article
Publication date: 2019-03-01
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 9.9
ISSN: 00219797, 10957103
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Colloid and Surface Chemistry
Biomaterials
Abstract
HYPOTHESIS
Hydrophobic bacteriochlorin based photosensitizer (PS) can be effectively immobilized on MNP covered by human serum albumin (HSA). PS loading into MNP protein shell allows solubilizing PS in water solution without altering its photodynamic activity. MNP@PS can serve as diagnostic tool for tracking PS delivery to tumor tissues by MRI.
EXPERIMENTS
Immobilization on MNP-HSA-PEG was performed by adding PS solution in organic solvents with further purification. MNP@PS were characterized by DLS, HAADF STEM and AFM. Absorbance and fluorescence measurements were used to assess PS photophysical properties before and after immobilization. MNP@PS internalization into CT26 cells was investigated by confocal microscopy in vitro and MRI/IVIS were used for tracking MNP@PS delivery to tumors in vivo.
FINDINGS
MNP@PS complexes were stable in water solution and retained PS photophysical activity. The length of side chain affected MNP@PS size, loading capacity and cell internalization. In vitro testing demonstrated MNP@PS delivery to cancer cells followed by photoinduced toxicity. In vivo studies confirmed that as-synthetized complexes can be used for MRI tracking over drug accumulation in tumors.
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Ostroverkhov P. et al. Synthesis and characterization of bacteriochlorin loaded magnetic nanoparticles (MNP) for personalized MRI guided photosensitizers delivery to tumor // Journal of Colloid and Interface Science. 2019. Vol. 537. pp. 132-141.
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Ostroverkhov P., Semkina A. S., Naumenko V., Plotnikova E. A., Melnikov P. A., Abakumova T. O., Yakubovskaya R. I., Mironov A. F., Vodopyanov S. S., Abakumov A. M., Majouga A. G., Grin M. A., Чехонин В. П., Abakumov M. A. Synthesis and characterization of bacteriochlorin loaded magnetic nanoparticles (MNP) for personalized MRI guided photosensitizers delivery to tumor // Journal of Colloid and Interface Science. 2019. Vol. 537. pp. 132-141.
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TY - JOUR
DO - 10.1016/j.jcis.2018.10.087
UR - https://doi.org/10.1016%2Fj.jcis.2018.10.087
TI - Synthesis and characterization of bacteriochlorin loaded magnetic nanoparticles (MNP) for personalized MRI guided photosensitizers delivery to tumor
T2 - Journal of Colloid and Interface Science
AU - Ostroverkhov, Petr
AU - Semkina, A S
AU - Naumenko, Victor
AU - Plotnikova, E A
AU - Melnikov, Pavel A
AU - Abakumova, T O
AU - Yakubovskaya, R. I.
AU - Mironov, Andrey F
AU - Vodopyanov, Stepan S
AU - Abakumov, Artem M.
AU - Majouga, Alexander G.
AU - Grin, Mikhail A.
AU - Чехонин, В. П.
AU - Abakumov, Maxim A.
PY - 2019
DA - 2019/03/01 00:00:00
PB - Elsevier
SP - 132-141
VL - 537
SN - 0021-9797
SN - 1095-7103
ER -
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@article{2019_Ostroverkhov,
author = {Petr Ostroverkhov and A S Semkina and Victor Naumenko and E A Plotnikova and Pavel A Melnikov and T O Abakumova and R. I. Yakubovskaya and Andrey F Mironov and Stepan S Vodopyanov and Artem M. Abakumov and Alexander G. Majouga and Mikhail A. Grin and В. П. Чехонин and Maxim A. Abakumov},
title = {Synthesis and characterization of bacteriochlorin loaded magnetic nanoparticles (MNP) for personalized MRI guided photosensitizers delivery to tumor},
journal = {Journal of Colloid and Interface Science},
year = {2019},
volume = {537},
publisher = {Elsevier},
month = {mar},
url = {https://doi.org/10.1016%2Fj.jcis.2018.10.087},
pages = {132--141},
doi = {10.1016/j.jcis.2018.10.087}
}