Open Access
Journal of Colloid and Interface Science, volume 608, pages 2571-2583
Impact of metallic coating on the retention of 225Ac and its daugthers within core–shell nanocarriers
Karpov Timofey E
1
,
Muslimov Albert R.
1, 2
,
Postovalova Alisa S
3
,
Shatik Sergey V
4
,
Zyuzin Mikhail V
,
Pavlov Dmitri A
5
,
Usov Yuri V
5
,
Antuganov Dmitrii O.
4
,
Zyuzin M V
6
,
Timin Alexander S.
1, 7
Publication type: Journal Article
Publication date: 2022-02-01
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 9.9
ISSN: 00219797, 10957103
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Colloid and Surface Chemistry
Biomaterials
Abstract
Currently, alpha-emitting radionuclide 225Ac is one of the most promising isotopes in alpha therapy due to its high linear energy transfer during four sequential alpha decays. However, the main obstacle preventing the full introduction of 225Ac into clinical practice is the lack of stable retention of radionuclides, leading to free circulation of toxic isotopes in the body. In this work, the surface of silica nanoparticles (SiO2 NPs) has been modified with metallic shells composed of titanium dioxide (TiO2) and gold (Au) nanostructures to improve the retention of 225Ac and its decay products within the developed nanocarriers. In vitro and in vivo studies in healthy mice show that the metallic surface coating of SiO2 NPs promotes an enhanced sequestering of radionuclides (225Ac and its daughter isotopes) compared to non-modified SiO2 NPs for a prolonged period of time. Histological analysis reveals that for the period of 3-10 d after the injections, the developed nanocarriers have no significant toxic effects in mice. At the same time, almost no accumulation of leaked radionuclides can be detected in non-target organs (e.g., in the kidneys). In contrast, non-modified carriers (SiO2 NPs) demonstrate the release of free radionuclides, which are distributed over the whole animal body with the consequent morphological changes in the lung, liver and kidney tissues. These results highlight the potential of the developed nanocarriers to be utilized as radionuclide delivery systems and offer an insight into design rules for the fabrication of new nanotherapeutic agents.
Citations by journals
|
1
|
|
|
ACS applied materials & interfaces
|
ACS applied materials & interfaces
1 publication, 20%
|
|
Frontiers in Medicine
|
Frontiers in Medicine
1 publication, 20%
|
|
Chemistry of Materials
|
Chemistry of Materials
1 publication, 20%
|
|
Inorganic Chemistry
|
Inorganic Chemistry
1 publication, 20%
|
|
Nuclear Medicine and Biology
|
Nuclear Medicine and Biology
1 publication, 20%
|
|
1
|
Citations by publishers
|
1
2
3
|
|
|
American Chemical Society (ACS)
|
American Chemical Society (ACS)
3 publications, 60%
|
|
Frontiers Media S.A.
|
Frontiers Media S.A.
1 publication, 20%
|
|
Elsevier
|
Elsevier
1 publication, 20%
|
|
1
2
3
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2022,2023,2024],"ids":[0,0,0],"codes":[0,0,0],"imageUrls":["","",""],"datasets":[{"label":"Citations number","data":[3,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6"],"percentage":["60","20","20"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["ACS applied materials & interfaces","Frontiers in Medicine","Chemistry of Materials","Inorganic Chemistry","Nuclear Medicine and Biology"],"ids":[1458,17043,6428,24714,404],"codes":[0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp"],"datasets":[{"label":"","data":[1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[20,20,20,20,20],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["American Chemical Society (ACS)","Frontiers Media S.A.","Elsevier"],"ids":[40,208,17],"codes":[0,0,0],"imageUrls":["\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp"],"datasets":[{"label":"","data":[3,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6"],"percentage":[60,20,20],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex
Cite this
GOST
Copy
Muslimov A. R. et al. Impact of metallic coating on the retention of 225Ac and its daugthers within core–shell nanocarriers // Journal of Colloid and Interface Science. 2022. Vol. 608. pp. 2571-2583.
GOST all authors (up to 50)
Copy
Muslimov A. R., Postovalova A. S., Shatik S. V., Zyuzin M. V., Karpov T. E., Pavlov D. A., Usov Y. V., Antuganov D. O., Zyuzin M. V., Timin A. S. Impact of metallic coating on the retention of 225Ac and its daugthers within core–shell nanocarriers // Journal of Colloid and Interface Science. 2022. Vol. 608. pp. 2571-2583.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.jcis.2021.10.187
UR - https://doi.org/10.1016%2Fj.jcis.2021.10.187
TI - Impact of metallic coating on the retention of 225Ac and its daugthers within core–shell nanocarriers
T2 - Journal of Colloid and Interface Science
AU - Muslimov, Albert R.
AU - Postovalova, Alisa S
AU - Shatik, Sergey V
AU - Zyuzin, Mikhail V
AU - Karpov, Timofey E
AU - Pavlov, Dmitri A
AU - Usov, Yuri V
AU - Antuganov, Dmitrii O.
AU - Zyuzin, M V
AU - Timin, Alexander S.
PY - 2022
DA - 2022/02/01 00:00:00
PB - Elsevier
SP - 2571-2583
VL - 608
SN - 0021-9797
SN - 1095-7103
ER -
Cite this
BibTex
Copy
@article{2022_Muslimov,
author = {Albert R. Muslimov and Alisa S Postovalova and Sergey V Shatik and Mikhail V Zyuzin and Timofey E Karpov and Dmitri A Pavlov and Yuri V Usov and Dmitrii O. Antuganov and M V Zyuzin and Alexander S. Timin},
title = {Impact of metallic coating on the retention of 225Ac and its daugthers within core–shell nanocarriers},
journal = {Journal of Colloid and Interface Science},
year = {2022},
volume = {608},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016%2Fj.jcis.2021.10.187},
pages = {2571--2583},
doi = {10.1016/j.jcis.2021.10.187}
}