Journal of Controlled Release, volume 161, issue 2, pages 505-522

PLGA-based nanoparticles: An overview of biomedical applications

Danhier Fabienne ¹

Ansorena Eduardo ¹

Silva Joana G. ^{1, 2}

Coco Régis ¹

Le Breton Aude ¹

Pr ?? at V??ronique ¹

Hide authors affiliations Show authors affiliations: 2 affiliations

Université Catholique de Louvain, Louvain Drug Research Institute, Pharmaceutics and Drug Delivery, Avenue Mounier, B1 73.12, 1200 Brussels, Belgium |

Nanomedicine & Drug Delivery Systems Group, iMed, Faculty of pharmacy, University of Lisbon, Lisbon, 1619-003, Portugal |

Publication type: Journal Article

Publication date: 2012-07-01

Elsevier

Journal: Journal of Controlled Release

Quartile SCImago

Quartile WOS

Impact factor: 10.8

ISSN: 01683659, 18734995

DOI: 10.1016/j.jconrel.2012.01.043

Copy DOI

Pharmaceutical Science

Abstract

Poly(lactic-co-glycolic acid) (PLGA) is one of the most successfully developed biodegradable polymers. Among the different polymers developed to formulate polymeric nanoparticles, PLGA has attracted considerable attention due to its attractive properties: (i) biodegradability and biocompatibility, (ii) FDA and European Medicine Agency approval in drug delivery systems for parenteral administration, (iii) well described formulations and methods of production adapted to various types of drugs e.g. hydrophilic or hydrophobic small molecules or macromolecules, (iv) protection of drug from degradation, (v) possibility of sustained release, (vi) possibility to modify surface properties to provide stealthness and/or better interaction with biological materials and (vii) possibility to target nanoparticles to specific organs or cells. This review presents why PLGA has been chosen to design nanoparticles as drug delivery systems in various biomedical applications such as vaccination, cancer, inflammation and other diseases. This review focuses on the understanding of specific characteristics exploited by PLGA-based nanoparticles to target a specific organ or tissue or specific cells.

By date By citations

Citations by journals

	10 20 30 40 50 60 70 80 90
International Journal of Pharmaceutics	International Journal of Pharmaceutics, 87, 3.56% International Journal of Pharmaceutics 87 publications, 3.56%
Journal of Controlled Release	Journal of Controlled Release, 76, 3.11% Journal of Controlled Release 76 publications, 3.11%
Pharmaceutics	Pharmaceutics, 58, 2.38% Pharmaceutics 58 publications, 2.38%
Journal of Drug Delivery Science and Technology	Journal of Drug Delivery Science and Technology, 49, 2.01% Journal of Drug Delivery Science and Technology 49 publications, 2.01%
Colloids and Surfaces B: Biointerfaces	Colloids and Surfaces B: Biointerfaces, 35, 1.43% Colloids and Surfaces B: Biointerfaces 35 publications, 1.43%
Acta Biomaterialia	Acta Biomaterialia, 32, 1.31% Acta Biomaterialia 32 publications, 1.31%
Scientific Reports	Scientific Reports, 30, 1.23% Scientific Reports 30 publications, 1.23%
Journal of Materials Chemistry B	Journal of Materials Chemistry B, 30, 1.23% Journal of Materials Chemistry B 30 publications, 1.23%
European Journal of Pharmaceutics and Biopharmaceutics	European Journal of Pharmaceutics and Biopharmaceutics, 29, 1.19% European Journal of Pharmaceutics and Biopharmaceutics 29 publications, 1.19%
International Journal of Biological Macromolecules	International Journal of Biological Macromolecules, 28, 1.15% International Journal of Biological Macromolecules 28 publications, 1.15%
RSC Advances	RSC Advances, 28, 1.15% RSC Advances 28 publications, 1.15%
Nanomedicine	Nanomedicine, 27, 1.11% Nanomedicine 27 publications, 1.11%
Biomacromolecules	Biomacromolecules, 27, 1.11% Biomacromolecules 27 publications, 1.11%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 26, 1.06% International Journal of Molecular Sciences 26 publications, 1.06%
Materials Science and Engineering C	Materials Science and Engineering C, 26, 1.06% Materials Science and Engineering C 26 publications, 1.06%
ACS applied materials & interfaces	ACS applied materials & interfaces, 26, 1.06% ACS applied materials & interfaces 26 publications, 1.06%
Molecular Pharmaceutics	Molecular Pharmaceutics, 25, 1.02% Molecular Pharmaceutics 25 publications, 1.02%
Polymers	Polymers, 24, 0.98% Polymers 24 publications, 0.98%
Advanced healthcare materials	Advanced healthcare materials, 24, 0.98% Advanced healthcare materials 24 publications, 0.98%
Frontiers in Bioengineering and Biotechnology	Frontiers in Bioengineering and Biotechnology, 23, 0.94% Frontiers in Bioengineering and Biotechnology 23 publications, 0.94%
Advanced Drug Delivery Reviews	Advanced Drug Delivery Reviews, 23, 0.94% Advanced Drug Delivery Reviews 23 publications, 0.94%
European Journal of Pharmaceutical Sciences	European Journal of Pharmaceutical Sciences, 23, 0.94% European Journal of Pharmaceutical Sciences 23 publications, 0.94%
Journal of Nanobiotechnology	Journal of Nanobiotechnology, 22, 0.9% Journal of Nanobiotechnology 22 publications, 0.9%
International Journal of Nanomedicine	International Journal of Nanomedicine, 22, 0.9% International Journal of Nanomedicine 22 publications, 0.9%
Biomaterials	Biomaterials, 22, 0.9% Biomaterials 22 publications, 0.9%
Molecules	Molecules, 21, 0.86% Molecules 21 publications, 0.86%
Nanomaterials	Nanomaterials, 20, 0.82% Nanomaterials 20 publications, 0.82%
Drug Delivery	Drug Delivery, 20, 0.82% Drug Delivery 20 publications, 0.82%
PLoS ONE	PLoS ONE, 18, 0.74% PLoS ONE 18 publications, 0.74%
	10 20 30 40 50 60 70 80 90

Citations by publishers

	100 200 300 400 500 600 700 800
Elsevier	Elsevier, 718, 29.4% Elsevier 718 publications, 29.4%
Springer Nature	Springer Nature, 242, 9.91% Springer Nature 242 publications, 9.91%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 236, 9.66% Multidisciplinary Digital Publishing Institute (MDPI) 236 publications, 9.66%
Wiley	Wiley, 185, 7.58% Wiley 185 publications, 7.58%
American Chemical Society (ACS)	American Chemical Society (ACS), 160, 6.55% American Chemical Society (ACS) 160 publications, 6.55%
Taylor & Francis	Taylor & Francis, 128, 5.24% Taylor & Francis 128 publications, 5.24%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 122, 5% Royal Society of Chemistry (RSC) 122 publications, 5%
Frontiers Media S.A.	Frontiers Media S.A., 75, 3.07% Frontiers Media S.A. 75 publications, 3.07%
Future Medicine	Future Medicine, 45, 1.84% Future Medicine 45 publications, 1.84%
Hindawi Limited	Hindawi Limited, 32, 1.31% Hindawi Limited 32 publications, 1.31%
Bentham Science	Bentham Science, 27, 1.11% Bentham Science 27 publications, 1.11%
Dove Medical Press	Dove Medical Press, 24, 0.98% Dove Medical Press 24 publications, 0.98%
IOP Publishing	IOP Publishing, 24, 0.98% IOP Publishing 24 publications, 0.98%
SAGE	SAGE, 20, 0.82% SAGE 20 publications, 0.82%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 18, 0.74% Public Library of Science (PLoS) 18 publications, 0.74%
Wolters Kluwer Health	Wolters Kluwer Health, 13, 0.53% Wolters Kluwer Health 13 publications, 0.53%
Mary Ann Liebert	Mary Ann Liebert, 11, 0.45% Mary Ann Liebert 11 publications, 0.45%
Pleiades Publishing	Pleiades Publishing, 7, 0.29% Pleiades Publishing 7 publications, 0.29%
American Scientific Publishers	American Scientific Publishers, 7, 0.29% American Scientific Publishers 7 publications, 0.29%
KeAi Communications Co.	KeAi Communications Co., 7, 0.29% KeAi Communications Co. 7 publications, 0.29%
Oxford University Press	Oxford University Press, 7, 0.29% Oxford University Press 7 publications, 0.29%
Institution of Engineering and Technology (IET)	Institution of Engineering and Technology (IET), 6, 0.25% Institution of Engineering and Technology (IET) 6 publications, 0.25%
Beilstein-Institut	Beilstein-Institut, 5, 0.2% Beilstein-Institut 5 publications, 0.2%
Spandidos Publications	Spandidos Publications, 5, 0.2% Spandidos Publications 5 publications, 0.2%
World Scientific	World Scientific, 5, 0.2% World Scientific 5 publications, 0.2%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 5, 0.2% American Association for the Advancement of Science (AAAS) 5 publications, 0.2%
Walter de Gruyter	Walter de Gruyter, 5, 0.2% Walter de Gruyter 5 publications, 0.2%
Shenyang Pharmaceutical University	Shenyang Pharmaceutical University, 4, 0.16% Shenyang Pharmaceutical University 4 publications, 0.16%
American Association for Cancer Research (AACR)	American Association for Cancer Research (AACR), 4, 0.16% American Association for Cancer Research (AACR) 4 publications, 0.16%
	100 200 300 400 500 600 700 800

We do not take into account publications that without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

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GOST Copy

Danhier F. et al. PLGA-based nanoparticles: An overview of biomedical applications // Journal of Controlled Release. 2012. Vol. 161. No. 2. pp. 505-522.

GOST all authors (up to 50) Copy

Danhier F., Ansorena E., Silva J. G., Coco R., Le Breton A., Pr ?? at V. PLGA-based nanoparticles: An overview of biomedical applications // Journal of Controlled Release. 2012. Vol. 161. No. 2. pp. 505-522.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.jconrel.2012.01.043

UR - https://doi.org/10.1016%2Fj.jconrel.2012.01.043

TI - PLGA-based nanoparticles: An overview of biomedical applications

T2 - Journal of Controlled Release

AU - Danhier, Fabienne

AU - Ansorena, Eduardo

AU - Silva, Joana G.

AU - Coco, Régis

AU - Le Breton, Aude

AU - Pr ?? at, V??ronique

PY - 2012

DA - 2012/07/01 00:00:00

PB - Elsevier

SP - 505-522

IS - 2

VL - 161

SN - 0168-3659

SN - 1873-4995

ER -

BibTex |

Cite this

BibTex Copy

@article{2012_Danhier,

author = {Fabienne Danhier and Eduardo Ansorena and Joana G. Silva and Régis Coco and Aude Le Breton and V??ronique Pr ?? at},

title = {PLGA-based nanoparticles: An overview of biomedical applications},

journal = {Journal of Controlled Release},

year = {2012},

volume = {161},

publisher = {Elsevier},

month = {jul},

url = {https://doi.org/10.1016%2Fj.jconrel.2012.01.043},

number = {2},

pages = {505--522},

doi = {10.1016/j.jconrel.2012.01.043}

}

MLA

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MLA Copy

Danhier, Fabienne, et al. “PLGA-based nanoparticles: An overview of biomedical applications.” Journal of Controlled Release, vol. 161, no. 2, Jul. 2012, pp. 505-522. https://doi.org/10.1016%2Fj.jconrel.2012.01.043.

Found error?

Publisher

Elsevier

Journal

Journal of Controlled Release

Quartile SCImago

Quartile WOS

Impact factor

10.8

ISSN

01683659 (Print)
18734995 (Electronic)