Journal of Controlled Release, volume 168, issue 2, pages 135-141
A new system for targeted delivery of doxorubicin into tumor cells.
Yabbarov N G
1
,
Severin E S.
2
,
Posypanova G A
,
Vorontsov E A
3
,
Obydenny S.I.
4
,
Posypanova G.
3
1
Bioengineering Centre, Russian Academy of Sciences, 7/1 Prospekt 60-Letiya Oktyabrya, Moscow 117312, Russia.
|
2
Russian Research Center of Molecular Diagnostics and Therapy, 8 Simpheropolsky blvd, Moscow, Russia
|
Publication type: Journal Article
Publication date: 2013-06-01
Journal:
Journal of Controlled Release
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 10.8
ISSN: 01683659, 18734995
Pharmaceutical Science
Abstract
The use of vector molecules for the targeted delivery of antitumor drugs provides their selectivity for cancer cells. The recombinant receptor-binding fragment of alpha-fetoprotein (rAFP3D) was used as a vector molecule. The specific receptor of alpha-fetoprotein is a universal tumor marker, being expressed on the surface of many tumor cells, but not in normal human tissues. And rAFP3D includes the receptor binding cite of AFP. A three-component delivery system including vector protein rAFP3D, PAMAM G2 dendrimer and antitumor antibiotic doxorubicin (Dox) was synthesized. The attachment of two dendrimer molecules to the vector protein did not affect the effectiveness of rAFP3D binding to AFP receptor on the surface of tumor cells nor the effectiveness of receptor-mediated endocytosis. Dox was conjugated with G2 via cis-aconitic anhydride (acid labile linker). The in vitro Dox release study showed that the conjugate was stable at neutral pH but was labile at pH<6. The Dox release was correlated with the intracellular distribution of conjugate in tumor cells. The rAFP3D-G2-Dox conjugate demonstrated a high cytotoxic activity against human ovarian adenocarcinoma cell lines: Dox-sensitive SKOV3 cells and Dox-resistant SKVLB cells and was low-toxic against human peripheral blood lymphocytes. Based on our findings, we may conclude that it is possible to significantly increase the effectiveness of Dox delivery to tumor cells by using the targeted delivery system comprising the recombinant third domain rAFP3D as a vector molecule.
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1
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6
8
10
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7 publications, 15.91%
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4 publications, 9.09%
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1 publication, 2.27%
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2
4
6
8
10
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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GOST
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Yabbarov N. G. et al. A new system for targeted delivery of doxorubicin into tumor cells. // Journal of Controlled Release. 2013. Vol. 168. No. 2. pp. 135-141.
GOST all authors (up to 50)
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Yabbarov N. G., Posypanova G. A., Vorontsov E. A., Obydenny S., Severin E. S., Posypanova G. A new system for targeted delivery of doxorubicin into tumor cells. // Journal of Controlled Release. 2013. Vol. 168. No. 2. pp. 135-141.
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TY - JOUR
DO - 10.1016/j.jconrel.2013.03.007
UR - https://doi.org/10.1016%2Fj.jconrel.2013.03.007
TI - A new system for targeted delivery of doxorubicin into tumor cells.
T2 - Journal of Controlled Release
AU - Yabbarov, N G
AU - Posypanova, G A
AU - Vorontsov, E A
AU - Obydenny, S.I.
AU - Severin, E S.
AU - Posypanova, G.
PY - 2013
DA - 2013/06/01 00:00:00
PB - Elsevier
SP - 135-141
IS - 2
VL - 168
SN - 0168-3659
SN - 1873-4995
ER -
Cite this
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@article{2013_Yabbarov,
author = {N G Yabbarov and G A Posypanova and E A Vorontsov and S.I. Obydenny and E S. Severin and G. Posypanova},
title = {A new system for targeted delivery of doxorubicin into tumor cells.},
journal = {Journal of Controlled Release},
year = {2013},
volume = {168},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016%2Fj.jconrel.2013.03.007},
number = {2},
pages = {135--141},
doi = {10.1016/j.jconrel.2013.03.007}
}
Cite this
MLA
Copy
Yabbarov, N. G., et al. “A new system for targeted delivery of doxorubicin into tumor cells..” Journal of Controlled Release, vol. 168, no. 2, Jun. 2013, pp. 135-141. https://doi.org/10.1016%2Fj.jconrel.2013.03.007.