Journal of Controlled Release, volume 172, issue 3, pages 782-794

Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles

Ernsting Mark J ¹

Murakami Mami ²

Roy Aniruddha ¹

Li Shyh-Yuan ^{3, 4, 5}

Hide authors affiliations Show authors affiliations: 5 affiliations

Drug Delivery and Formulation, Drug Discovery Program , Ontario Institute for Cancer Research , 101 College Street, Suite 800 , Toronto , Ontario M5G 0A3 , Canada. |

Ryerson University, Faculty of Architectural Science and Engineering, Toronto, Ontario M5B 1Z2, Canada. |

Drug Delivery and Formulation, Drug Discovery Program, Ontario Institute for Cancer Research, 101 College Street, Suite 800, Toronto, Ontario M5G 0A3, Canada |

⁴

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2, Canada |

⁵

The Techna Institute, University Health Network, Toronto, Ontario M5G 1P5, Canada |

Publication type: Journal Article

Publication date: 2013-12-01

Elsevier

Journal: Journal of Controlled Release

Quartile SCImago

Quartile WOS

Impact factor: 10.8

ISSN: 01683659, 18734995

DOI: 10.1016/j.jconrel.2013.09.013

Copy DOI

PubMed ID: 24075927

Pharmaceutical Science

Abstract

Nanoparticle drug delivery to the tumor is impacted by multiple factors: nanoparticles must evade clearance by renal filtration and the reticuloendothelial system, extravasate through the enlarged endothelial gaps in tumors, penetrate through dense stroma in the tumor microenvironment to reach the tumor cells, remain in the tumor tissue for a prolonged period of time, and finally release the active agent to induce pharmacological effect. The physicochemical properties of nanoparticles such as size, shape, surface charge, surface chemistry (PEGylation, ligand conjugation) and composition affect the pharmacokinetics, biodistribution, intratumoral penetration and tumor bioavailability. On the other hand, tumor biology (blood flow, perfusion, permeability, interstitial fluid pressure and stroma content) and patient characteristics (age, gender, tumor type, tumor location, body composition and prior treatments) also have impact on drug delivery by nanoparticles. It is now believed that both nanoparticles and the tumor microenvironment have to be optimized or adjusted for optimal delivery. This review provides a comprehensive summary of how these nanoparticle and biological factors impact nanoparticle delivery to tumors, with discussion on how the tumor microenvironment can be adjusted and how patients can be stratified by imaging methods to receive the maximal benefit of nanomedicine. Perspectives and future directions are also provided.

By date By citations

Citations by journals

	5 10 15 20 25 30 35 40 45 50
Journal of Controlled Release	Journal of Controlled Release, 49, 6.7% Journal of Controlled Release 49 publications, 6.7%
ACS Nano	ACS Nano, 20, 2.74% ACS Nano 20 publications, 2.74%
ACS applied materials & interfaces	ACS applied materials & interfaces, 20, 2.74% ACS applied materials & interfaces 20 publications, 2.74%
Advanced Drug Delivery Reviews	Advanced Drug Delivery Reviews, 19, 2.6% Advanced Drug Delivery Reviews 19 publications, 2.6%
Biomaterials	Biomaterials, 18, 2.46% Biomaterials 18 publications, 2.46%
Pharmaceutics	Pharmaceutics, 17, 2.33% Pharmaceutics 17 publications, 2.33%
Advanced healthcare materials	Advanced healthcare materials, 15, 2.05% Advanced healthcare materials 15 publications, 2.05%
International Journal of Pharmaceutics	International Journal of Pharmaceutics, 14, 1.92% International Journal of Pharmaceutics 14 publications, 1.92%
Journal of Materials Chemistry B	Journal of Materials Chemistry B, 13, 1.78% Journal of Materials Chemistry B 13 publications, 1.78%
Colloids and Surfaces B: Biointerfaces	Colloids and Surfaces B: Biointerfaces, 12, 1.64% Colloids and Surfaces B: Biointerfaces 12 publications, 1.64%
Advanced Functional Materials	Advanced Functional Materials, 11, 1.5% Advanced Functional Materials 11 publications, 1.5%
Nanomaterials	Nanomaterials, 10, 1.37% Nanomaterials 10 publications, 1.37%
Molecular Pharmaceutics	Molecular Pharmaceutics, 10, 1.37% Molecular Pharmaceutics 10 publications, 1.37%
Biomaterials Science	Biomaterials Science, 10, 1.37% Biomaterials Science 10 publications, 1.37%
Scientific Reports	Scientific Reports, 9, 1.23% Scientific Reports 9 publications, 1.23%
Nanomedicine	Nanomedicine, 8, 1.09% Nanomedicine 8 publications, 1.09%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 8, 1.09% International Journal of Molecular Sciences 8 publications, 1.09%
Small	Small, 8, 1.09% Small 8 publications, 1.09%
Journal of Drug Delivery Science and Technology	Journal of Drug Delivery Science and Technology, 8, 1.09% Journal of Drug Delivery Science and Technology 8 publications, 1.09%
Biomacromolecules	Biomacromolecules, 8, 1.09% Biomacromolecules 8 publications, 1.09%
Acta Biomaterialia	Acta Biomaterialia, 7, 0.96% Acta Biomaterialia 7 publications, 0.96%
European Journal of Pharmaceutics and Biopharmaceutics	European Journal of Pharmaceutics and Biopharmaceutics, 7, 0.96% European Journal of Pharmaceutics and Biopharmaceutics 7 publications, 0.96%
Nanoscale	Nanoscale, 7, 0.96% Nanoscale 7 publications, 0.96%
Pharmaceutical Research	Pharmaceutical Research, 6, 0.82% Pharmaceutical Research 6 publications, 0.82%
Nanotechnology	Nanotechnology, 6, 0.82% Nanotechnology 6 publications, 0.82%
Nanomedicine: Nanotechnology, Biology, and Medicine	Nanomedicine: Nanotechnology, Biology, and Medicine, 6, 0.82% Nanomedicine: Nanotechnology, Biology, and Medicine 6 publications, 0.82%
Advanced Materials	Advanced Materials, 6, 0.82% Advanced Materials 6 publications, 0.82%
Bioconjugate Chemistry	Bioconjugate Chemistry, 6, 0.82% Bioconjugate Chemistry 6 publications, 0.82%
ACS Biomaterials Science and Engineering	ACS Biomaterials Science and Engineering, 6, 0.82% ACS Biomaterials Science and Engineering 6 publications, 0.82%
	5 10 15 20 25 30 35 40 45 50

Citations by publishers

	50 100 150 200 250
Elsevier	Elsevier, 233, 31.87% Elsevier 233 publications, 31.87%
American Chemical Society (ACS)	American Chemical Society (ACS), 94, 12.86% American Chemical Society (ACS) 94 publications, 12.86%
Wiley	Wiley, 78, 10.67% Wiley 78 publications, 10.67%
Springer Nature	Springer Nature, 66, 9.03% Springer Nature 66 publications, 9.03%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 57, 7.8% Multidisciplinary Digital Publishing Institute (MDPI) 57 publications, 7.8%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 49, 6.7% Royal Society of Chemistry (RSC) 49 publications, 6.7%
Taylor & Francis	Taylor & Francis, 23, 3.15% Taylor & Francis 23 publications, 3.15%
Future Medicine	Future Medicine, 11, 1.5% Future Medicine 11 publications, 1.5%
IOP Publishing	IOP Publishing, 10, 1.37% IOP Publishing 10 publications, 1.37%
Frontiers Media S.A.	Frontiers Media S.A., 9, 1.23% Frontiers Media S.A. 9 publications, 1.23%
Dove Medical Press	Dove Medical Press, 4, 0.55% Dove Medical Press 4 publications, 0.55%
Hindawi Limited	Hindawi Limited, 3, 0.41% Hindawi Limited 3 publications, 0.41%
American Association for Cancer Research (AACR)	American Association for Cancer Research (AACR), 3, 0.41% American Association for Cancer Research (AACR) 3 publications, 0.41%
Bentham Science	Bentham Science, 2, 0.27% Bentham Science 2 publications, 0.27%
Impact Journals	Impact Journals, 2, 0.27% Impact Journals 2 publications, 0.27%
Mary Ann Liebert	Mary Ann Liebert, 2, 0.27% Mary Ann Liebert 2 publications, 0.27%
Pharmaceutical Society of Japan	Pharmaceutical Society of Japan, 2, 0.27% Pharmaceutical Society of Japan 2 publications, 0.27%
Wolters Kluwer Health	Wolters Kluwer Health, 2, 0.27% Wolters Kluwer Health 2 publications, 0.27%
KeAi Communications Co.	KeAi Communications Co., 2, 0.27% KeAi Communications Co. 2 publications, 0.27%
Oxford University Press	Oxford University Press, 2, 0.27% Oxford University Press 2 publications, 0.27%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 2, 0.27% Proceedings of the National Academy of Sciences (PNAS) 2 publications, 0.27%
PeerJ	PeerJ, 1, 0.14% PeerJ 1 publication, 0.14%
Society of Nuclear Medicine and Molecular Imaging	Society of Nuclear Medicine and Molecular Imaging, 1, 0.14% Society of Nuclear Medicine and Molecular Imaging 1 publication, 0.14%
Spandidos Publications	Spandidos Publications, 1, 0.14% Spandidos Publications 1 publication, 0.14%
World Scientific	World Scientific, 1, 0.14% World Scientific 1 publication, 0.14%
King Saud University	King Saud University, 1, 0.14% King Saud University 1 publication, 0.14%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 1, 0.14% Public Library of Science (PLoS) 1 publication, 0.14%
Shenyang Pharmaceutical University	Shenyang Pharmaceutical University, 1, 0.14% Shenyang Pharmaceutical University 1 publication, 0.14%
Pleiades Publishing	Pleiades Publishing, 1, 0.14% Pleiades Publishing 1 publication, 0.14%
	50 100 150 200 250

We do not take into account publications that without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

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GOST Copy

Ernsting M. J. et al. Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles // Journal of Controlled Release. 2013. Vol. 172. No. 3. pp. 782-794.

GOST all authors (up to 50) Copy

Ernsting M. J., Murakami M., Roy A., Li S. Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles // Journal of Controlled Release. 2013. Vol. 172. No. 3. pp. 782-794.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.jconrel.2013.09.013

UR - https://doi.org/10.1016%2Fj.jconrel.2013.09.013

TI - Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles

T2 - Journal of Controlled Release

AU - Ernsting, Mark J

AU - Murakami, Mami

AU - Roy, Aniruddha

AU - Li, Shyh-Yuan

PY - 2013

DA - 2013/12/01 00:00:00

PB - Elsevier

SP - 782-794

IS - 3

VL - 172

PMID - 24075927

SN - 0168-3659

SN - 1873-4995

ER -

BibTex |

Cite this

BibTex Copy

@article{2013_Ernsting,

author = {Mark J Ernsting and Mami Murakami and Aniruddha Roy and Shyh-Yuan Li},

title = {Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles},

journal = {Journal of Controlled Release},

year = {2013},

volume = {172},

publisher = {Elsevier},

month = {dec},

url = {https://doi.org/10.1016%2Fj.jconrel.2013.09.013},

number = {3},

pages = {782--794},

doi = {10.1016/j.jconrel.2013.09.013}

}

MLA

Cite this

MLA Copy

Ernsting, Mark J., et al. “Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles.” Journal of Controlled Release, vol. 172, no. 3, Dec. 2013, pp. 782-794. https://doi.org/10.1016%2Fj.jconrel.2013.09.013.

Found error?

Publisher

Elsevier

Journal

Journal of Controlled Release

Quartile SCImago

Quartile WOS

Impact factor

10.8

ISSN

01683659 (Print)
18734995 (Electronic)