Journal of Controlled Release, volume 307, pages 368-378
Intravital microscopy reveals a novel mechanism of nanoparticles excretion in kidney
Naumenko Victor
1
,
Alieva Irina
2
,
Golyshev Sergei
,
Valikhov Marat
3
,
Ilyasov Artem
1
,
Vishnevskiy Daniil
3
,
Abakumov Maxim
,
Chekhonin Vladimir
,
Majouga Alexander
,
Garanina Anastasiia
,
Melnikov Pavel A
,
Vodopyanov Stepan
,
Kapitanova Ksenia
4
,
Markov Aleksey
4
,
Zhukov Dmitry
,
Nikitin Aleksey A
5, 6
,
Melnikov Pavel
3
,
Garanina A. S.
1
,
Zhukov Dmitry
1
,
Abakumov Maxim A.
6, 7
,
Чехонин В. П.
3
,
Majouga Alexander G.
6, 8
Publication type: Journal Article
Publication date: 2019-08-01
Journal:
Journal of Controlled Release
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 10.8
ISSN: 01683659, 18734995
Pharmaceutical Science
Abstract
Developing nanocarriers that accumulate in targeted organs and are harmlessly eliminated still remains a big challenge. Nanoparticles (NP) biodistribution is governed by their size, composition, surface charge and coverage. The current thinking in bionanotechnology is that renal clearance is limited by glomerular basement membrane pore size (≈6 nm), although there is a growing evidence that NP exceeding the threshold can also be excreted with urine. Here we compare biodistribution of PEGylated 140 nm iron oxide cubes and clusters with a special focus on renal accumulation and excretion. Atomic emission spectroscopy, fluorescent microscopy and magnetic resonance imaging revealed rapid and transient accumulation of magnetic NP in kidney. Using intravital microscopy we tracked in real time NP translocation from peritubular capillaries to basal compartment of tubular cells and subsequent excretion to the lumen within 60 min after systemic administration. Transmission electron microscopy revealed persistence of intact full-sized NP in urine 2 h post injection. The results suggest that translocation through peritubular endothelium to tubular epithelial cells is an alternative mechanism of renal clearance enabling excretion of NP above glomerular cut-off size.
Citations by journals
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Citations by publishers
2
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4 publications, 10.53%
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4 publications, 10.53%
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|
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1 publication, 2.63%
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Taylor & Francis
|
Taylor & Francis
1 publication, 2.63%
|
American Association for the Advancement of Science (AAAS)
|
American Association for the Advancement of Science (AAAS)
1 publication, 2.63%
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2
4
6
8
10
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Naumenko V. et al. Intravital microscopy reveals a novel mechanism of nanoparticles excretion in kidney // Journal of Controlled Release. 2019. Vol. 307. pp. 368-378.
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Valikhov M., Garanina A., Vodopyanov S., Kapitanova K., Nikitin A., Majouga A., Zhukov D., Markov A., Chekhonin V., Abakumov M., Alieva I., Golyshev S., Vishnevskiy D., Ilyasov A., Naumenko V., Melnikov P. A., Nikitin A. A., Melnikov P., Vodopyanov S. S., Garanina A. S., Golyshev S. A., Zhukov D., Abakumov M. A., Чехонин В. П., Majouga A. G. Intravital microscopy reveals a novel mechanism of nanoparticles excretion in kidney // Journal of Controlled Release. 2019. Vol. 307. pp. 368-378.
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TY - JOUR
DO - 10.1016/j.jconrel.2019.06.026
UR - https://doi.org/10.1016%2Fj.jconrel.2019.06.026
TI - Intravital microscopy reveals a novel mechanism of nanoparticles excretion in kidney
T2 - Journal of Controlled Release
AU - Naumenko, Victor
AU - Valikhov, Marat
AU - Ilyasov, Artem
AU - Vishnevskiy, Daniil
AU - Golyshev, Sergei
AU - Alieva, Irina
AU - Abakumov, Maxim
AU - Chekhonin, Vladimir
AU - Melnikov, Pavel A
AU - Markov, Aleksey
AU - Zhukov, Dmitry
AU - Majouga, Alexander
AU - Nikitin, Aleksey
AU - Kapitanova, Ksenia
AU - Vodopyanov, Stepan
AU - Garanina, Anastasiia
AU - Nikitin, Aleksey A
AU - Melnikov, Pavel
AU - Vodopyanov, Stepan S
AU - Garanina, A. S.
AU - Golyshev, Sergey A.
AU - Zhukov, Dmitry
AU - Abakumov, Maxim A.
AU - Чехонин, В. П.
AU - Majouga, Alexander G.
PY - 2019
DA - 2019/08/01 00:00:00
PB - Elsevier
SP - 368-378
VL - 307
SN - 0168-3659
SN - 1873-4995
ER -
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@article{2019_Naumenko
author = {Victor Naumenko and Marat Valikhov and Artem Ilyasov and Daniil Vishnevskiy and Sergei Golyshev and Irina Alieva and Maxim Abakumov and Vladimir Chekhonin and Pavel A Melnikov and Aleksey Markov and Dmitry Zhukov and Alexander Majouga and Aleksey Nikitin and Ksenia Kapitanova and Stepan Vodopyanov and Anastasiia Garanina and Aleksey A Nikitin and Pavel Melnikov and Stepan S Vodopyanov and A. S. Garanina and Sergey A. Golyshev and Dmitry Zhukov and Maxim A. Abakumov and В. П. Чехонин and Alexander G. Majouga},
title = {Intravital microscopy reveals a novel mechanism of nanoparticles excretion in kidney},
journal = {Journal of Controlled Release},
year = {2019},
volume = {307},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016%2Fj.jconrel.2019.06.026},
pages = {368--378},
doi = {10.1016/j.jconrel.2019.06.026}
}