Journal of Controlled Release, volume 307, pages 368-378

Intravital microscopy reveals a novel mechanism of nanoparticles excretion in kidney

Alieva Irina 2
Golyshev Sergei
Valikhov Marat 3
Ilyasov Artem 1
Vishnevskiy Daniil 3
Abakumov Maxim
Chekhonin Vladimir
Majouga Alexander
Garanina Anastasiia
Melnikov Pavel A
Vodopyanov Stepan
Kapitanova Ksenia 4
Markov Aleksey 4
Zhukov Dmitry
Melnikov Pavel 3
Zhukov Dmitry 1
Чехонин В. П. 3
Publication typeJournal Article
Publication date2019-08-01
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor10.8
ISSN01683659, 18734995
Pharmaceutical Science
Abstract
Developing nanocarriers that accumulate in targeted organs and are harmlessly eliminated still remains a big challenge. Nanoparticles (NP) biodistribution is governed by their size, composition, surface charge and coverage. The current thinking in bionanotechnology is that renal clearance is limited by glomerular basement membrane pore size (≈6 nm), although there is a growing evidence that NP exceeding the threshold can also be excreted with urine. Here we compare biodistribution of PEGylated 140 nm iron oxide cubes and clusters with a special focus on renal accumulation and excretion. Atomic emission spectroscopy, fluorescent microscopy and magnetic resonance imaging revealed rapid and transient accumulation of magnetic NP in kidney. Using intravital microscopy we tracked in real time NP translocation from peritubular capillaries to basal compartment of tubular cells and subsequent excretion to the lumen within 60 min after systemic administration. Transmission electron microscopy revealed persistence of intact full-sized NP in urine 2 h post injection. The results suggest that translocation through peritubular endothelium to tubular epithelial cells is an alternative mechanism of renal clearance enabling excretion of NP above glomerular cut-off size.

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Naumenko V. et al. Intravital microscopy reveals a novel mechanism of nanoparticles excretion in kidney // Journal of Controlled Release. 2019. Vol. 307. pp. 368-378.
GOST all authors (up to 50) Copy
Valikhov M., Garanina A., Vodopyanov S., Kapitanova K., Nikitin A., Majouga A., Zhukov D., Markov A., Chekhonin V., Abakumov M., Alieva I., Golyshev S., Vishnevskiy D., Ilyasov A., Naumenko V., Melnikov P. A., Nikitin A. A., Melnikov P., Vodopyanov S. S., Garanina A. S., Golyshev S. A., Zhukov D., Abakumov M. A., Чехонин В. П., Majouga A. G. Intravital microscopy reveals a novel mechanism of nanoparticles excretion in kidney // Journal of Controlled Release. 2019. Vol. 307. pp. 368-378.
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RIS Copy
TY - JOUR
DO - 10.1016/j.jconrel.2019.06.026
UR - https://doi.org/10.1016%2Fj.jconrel.2019.06.026
TI - Intravital microscopy reveals a novel mechanism of nanoparticles excretion in kidney
T2 - Journal of Controlled Release
AU - Naumenko, Victor
AU - Valikhov, Marat
AU - Ilyasov, Artem
AU - Vishnevskiy, Daniil
AU - Golyshev, Sergei
AU - Alieva, Irina
AU - Abakumov, Maxim
AU - Chekhonin, Vladimir
AU - Melnikov, Pavel A
AU - Markov, Aleksey
AU - Zhukov, Dmitry
AU - Majouga, Alexander
AU - Nikitin, Aleksey
AU - Kapitanova, Ksenia
AU - Vodopyanov, Stepan
AU - Garanina, Anastasiia
AU - Nikitin, Aleksey A
AU - Melnikov, Pavel
AU - Vodopyanov, Stepan S
AU - Garanina, A. S.
AU - Golyshev, Sergey A.
AU - Zhukov, Dmitry
AU - Abakumov, Maxim A.
AU - Чехонин, В. П.
AU - Majouga, Alexander G.
PY - 2019
DA - 2019/08/01 00:00:00
PB - Elsevier
SP - 368-378
VL - 307
SN - 0168-3659
SN - 1873-4995
ER -
BibTex
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BibTex Copy
@article{2019_Naumenko
author = {Victor Naumenko and Marat Valikhov and Artem Ilyasov and Daniil Vishnevskiy and Sergei Golyshev and Irina Alieva and Maxim Abakumov and Vladimir Chekhonin and Pavel A Melnikov and Aleksey Markov and Dmitry Zhukov and Alexander Majouga and Aleksey Nikitin and Ksenia Kapitanova and Stepan Vodopyanov and Anastasiia Garanina and Aleksey A Nikitin and Pavel Melnikov and Stepan S Vodopyanov and A. S. Garanina and Sergey A. Golyshev and Dmitry Zhukov and Maxim A. Abakumov and В. П. Чехонин and Alexander G. Majouga},
title = {Intravital microscopy reveals a novel mechanism of nanoparticles excretion in kidney},
journal = {Journal of Controlled Release},
year = {2019},
volume = {307},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016%2Fj.jconrel.2019.06.026},
pages = {368--378},
doi = {10.1016/j.jconrel.2019.06.026}
}
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