Journal of Controlled Release, volume 330, pages 244-256

Intravital imaging of liposome behavior upon repeated administration: A step towards the development of liposomal companion diagnostic for cancer nanotherapy.

Naumenko Victor ¹

Vodopyanov Stepan S ^{2, 3}

Vlasova Kseniya Yu. ^{4, 5}

Potashnikova Daria M. ⁶

Melnikov Pavel A ¹

Vishnevskiy Daniil A ¹

Garanina A. S. ⁷

Valikhov Marat P. ⁸

Lipatova Anastasiia V ⁹

Чехонин В. П. ^{4, 10}

Majouga Alexander G. ^{3, 11}

Abakumov Maxim A. ^{3, 4}

Hide authors affiliations Show authors affiliations: 11 affiliations

V. Serbsky National Medical Research Center for Psychiatry and Narcology, Moscow 119034, Russia. |

M.V. Lomonosov Moscow State University, School of Biology, Moscow 119234, Russia. |

National University of Science and Technology (MISiS), Moscow 119049, Russia |

⁴

Department of Medical Nanobiotechnology, N.I Pirogov Russian National Research Medical University, Moscow 117997, Russia. |

⁵

M.V. Lomonosov Moscow State University, School of Chemistry, Moscow 119991, Russia |

⁶

M.V. Lomonosov Moscow State University, School of Biology, Moscow 119234, Russia |

⁷

National University of Science and Technology (MISiS), Moscow, 119049, Russia. |

⁸

Department of Medical Nanobiotechnology, N.I Pirogov Russian National Research Medical University, Moscow 117997, Russia |

⁹

Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia. |

¹⁰

V. Serbsky National Medical Research Center for Psychiatry and Narcology, Moscow 119034, Russia |

¹¹

D. Mendeleev University of Chemical Technology of Russia, Moscow 125047, Russia. |

Publication type: Journal Article

Publication date: 2021-02-01

Elsevier

Journal: Journal of Controlled Release

Quartile SCImago

Quartile WOS

Impact factor: 10.8

ISSN: 01683659, 18734995

DOI: 10.1016/j.jconrel.2020.12.014

Copy DOI

Pharmaceutical Science

Abstract

Accumulation of liposomal drugs into human tumors has substantial variability influencing the probability of positive response to the therapy. Therefore, it becomes very important to identify the eligibility of patients for various treatment options. The existing strategies of tumor stratification using companion diagnostics are based on the assumption that the initial and subsequent doses of nanoparticles (NP) behave in a sufficiently similar manner to enable a valuable prognosis. Here, we use a combination of in vivo imaging techniques to validate the applicability of magnetic liposomes (ML) as a reliable tool to predict whether or not the tumor would respond to nanomedicine therapy. The results demonstrated that liposome biodistribution, interactions with immune cells, and extravasation behavior in tumors were not affected by the pretreatment with liposomes 24 h prior to the repeat dosing. Co-administration of liposomal doxorubicin (DXR) and liposomes loaded with maghemite NP resulted in a high colocalization rate between two nanomedicines in tumors suggesting that neither contrast agent, nor chemotherapeutics altered biodistribution of liposomes. Based on magnetic resonance imaging of 4T1 tumors performed before and 6 h after ML treatment, animals were classified into high and low accumulation subgroups. Higher ML deposition in tumors was associated with a reduction in lesion size and enhanced survival in animals treated with liposomal DXR, but not with DXR alone. Given that liposomes are the most numerous class of clinically approved nanomedicines the development of safe and cost-effective liposomal companion diagnostic suitable for non-invasive imaging is of paramount importance for improving the efficacy of cancer therapy.

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Citations by journals

	1
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 1, 10% International Journal of Molecular Sciences 1 publication, 10%
Advanced Drug Delivery Reviews	Advanced Drug Delivery Reviews, 1, 10% Advanced Drug Delivery Reviews 1 publication, 10%
ACS Nano	ACS Nano, 1, 10% ACS Nano 1 publication, 10%
Molecular Pharmaceutics	Molecular Pharmaceutics, 1, 10% Molecular Pharmaceutics 1 publication, 10%
Drug Delivery	Drug Delivery, 1, 10% Drug Delivery 1 publication, 10%
Advanced Science	Advanced Science, 1, 10% Advanced Science 1 publication, 10%
iScience	iScience, 1, 10% iScience 1 publication, 10%
npj Vaccines	npj Vaccines, 1, 10% npj Vaccines 1 publication, 10%
	1

Citations by publishers

	1 2
Elsevier	Elsevier, 2, 20% Elsevier 2 publications, 20%
American Chemical Society (ACS)	American Chemical Society (ACS), 2, 20% American Chemical Society (ACS) 2 publications, 20%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 1, 10% Multidisciplinary Digital Publishing Institute (MDPI) 1 publication, 10%
Taylor & Francis	Taylor & Francis, 1, 10% Taylor & Francis 1 publication, 10%
Wiley	Wiley, 1, 10% Wiley 1 publication, 10%
Springer Nature	Springer Nature, 1, 10% Springer Nature 1 publication, 10%
	1 2

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Naumenko V. et al. Intravital imaging of liposome behavior upon repeated administration: A step towards the development of liposomal companion diagnostic for cancer nanotherapy. // Journal of Controlled Release. 2021. Vol. 330. pp. 244-256.

GOST all authors (up to 50) Copy

Naumenko V., Vodopyanov S. S., Vlasova K. Y., Potashnikova D. M., Melnikov P. A., Vishnevskiy D. A., Garanina A. S., Valikhov M. P., Lipatova A. V., Чехонин В. П., Majouga A. G., Abakumov M. A. Intravital imaging of liposome behavior upon repeated administration: A step towards the development of liposomal companion diagnostic for cancer nanotherapy. // Journal of Controlled Release. 2021. Vol. 330. pp. 244-256.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.jconrel.2020.12.014

UR - https://doi.org/10.1016%2Fj.jconrel.2020.12.014

TI - Intravital imaging of liposome behavior upon repeated administration: A step towards the development of liposomal companion diagnostic for cancer nanotherapy.

T2 - Journal of Controlled Release

AU - Naumenko, Victor

AU - Vodopyanov, Stepan S

AU - Vlasova, Kseniya Yu.

AU - Potashnikova, Daria M.

AU - Melnikov, Pavel A

AU - Vishnevskiy, Daniil A

AU - Garanina, A. S.

AU - Valikhov, Marat P.

AU - Lipatova, Anastasiia V

AU - Чехонин, В. П.

AU - Majouga, Alexander G.

AU - Abakumov, Maxim A.

PY - 2021

DA - 2021/02/01 00:00:00

PB - Elsevier

SP - 244-256

VL - 330

SN - 0168-3659

SN - 1873-4995

ER -

BibTex

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BibTex Copy

@article{2021_Naumenko,

author = {Victor Naumenko and Stepan S Vodopyanov and Kseniya Yu. Vlasova and Daria M. Potashnikova and Pavel A Melnikov and Daniil A Vishnevskiy and A. S. Garanina and Marat P. Valikhov and Anastasiia V Lipatova and В. П. Чехонин and Alexander G. Majouga and Maxim A. Abakumov},

title = {Intravital imaging of liposome behavior upon repeated administration: A step towards the development of liposomal companion diagnostic for cancer nanotherapy.},

journal = {Journal of Controlled Release},

year = {2021},

volume = {330},

publisher = {Elsevier},

month = {feb},

url = {https://doi.org/10.1016%2Fj.jconrel.2020.12.014},

pages = {244--256},

doi = {10.1016/j.jconrel.2020.12.014}

}

Found error?

Publisher

Elsevier

Journal

Journal of Controlled Release

Quartile SCImago

Quartile WOS

Impact factor

10.8

ISSN

01683659 (Print)
18734995 (Electronic)

Labs

Biomedical Nanomaterials Laboratory

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