Journal of Drug Delivery Science and Technology, volume 60, pages 102013

Inhalable linezolid loaded PLGA nanoparticles for treatment of tuberculosis: Design, development and in vitro evaluation

Shah Sunny 1
Cristopher Dhanya 1
Sharma Shweta 1
Soniwala Moinuddin 1
Chavda Jayant 1
1
 
Bhagvanlal Kapoorchand Mody Government Pharmacy College, Rajkot, India.
Publication typeJournal Article
Publication date2020-12-01
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor5
ISSN17732247, 25888943
Pharmaceutical Science
Abstract
The present study is aimed to design and develop linezolid loaded PLGA nanoparticles (LZ NPs) for treatment of pulmonary tuberculosis. The objective was to prepare LZ NPs with a mean particle size below 300 nm and having Mass Median Aerodynamic Diameter (MMAD) less than 5 μm and sustain the drug release up to 120 h. The LZ NPs were prepared by modified emulsion solvent evaporation method using high-speed homogenization, sonication and subsequent lyophilization. Preliminary studies revealed that dimethyl sulphoxide was a suitable organic phase while α – phosphatidylcholine and PVP S 630 D were the suitable stabilizers for stabilizing the nanoparticles. A 32 full factorial design revealed that both process variables namely homogenization time and homogenization speed had a significant effect (p

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GOST Copy
Shah S. et al. Inhalable linezolid loaded PLGA nanoparticles for treatment of tuberculosis: Design, development and in vitro evaluation // Journal of Drug Delivery Science and Technology. 2020. Vol. 60. p. 102013.
GOST all authors (up to 50) Copy
Shah S., Cristopher D., Sharma S., Soniwala M., Chavda J. Inhalable linezolid loaded PLGA nanoparticles for treatment of tuberculosis: Design, development and in vitro evaluation // Journal of Drug Delivery Science and Technology. 2020. Vol. 60. p. 102013.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1016/j.jddst.2020.102013
UR - https://doi.org/10.1016%2Fj.jddst.2020.102013
TI - Inhalable linezolid loaded PLGA nanoparticles for treatment of tuberculosis: Design, development and in vitro evaluation
T2 - Journal of Drug Delivery Science and Technology
AU - Shah, Sunny
AU - Cristopher, Dhanya
AU - Sharma, Shweta
AU - Soniwala, Moinuddin
AU - Chavda, Jayant
PY - 2020
DA - 2020/12/01 00:00:00
PB - Elsevier
SP - 102013
VL - 60
SN - 1773-2247
SN - 2588-8943
ER -
BibTex
Cite this
BibTex Copy
@article{2020_Shah
author = {Sunny Shah and Dhanya Cristopher and Shweta Sharma and Moinuddin Soniwala and Jayant Chavda},
title = {Inhalable linezolid loaded PLGA nanoparticles for treatment of tuberculosis: Design, development and in vitro evaluation},
journal = {Journal of Drug Delivery Science and Technology},
year = {2020},
volume = {60},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016%2Fj.jddst.2020.102013},
pages = {102013},
doi = {10.1016/j.jddst.2020.102013}
}
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