Journal of Drug Delivery Science and Technology, volume 61, pages 102157

Folate-targeted nanomicelles containing silibinin as an active drug delivery system for liver cancer therapy

Ghalehkhondabi Vahab ¹

Soleymani Meysam ¹

Fazlali Alireza ¹

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Department of Chemical Engineering, Faculty of Engineering, Arak University 3848177584, Arak, Iran |

Publication type: Journal Article

Publication date: 2021-02-01

Elsevier

Journal: Journal of Drug Delivery Science and Technology

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Impact factor: 5

ISSN: 17732247, 25888943

DOI: 10.1016/j.jddst.2020.102157

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Pharmaceutical Science

Abstract

The majority of herbal anticancer drugs are insoluble in water or become unstable during their transport to tumor tissues, hence they require a special drug delivery system. The main target of this study was to evaluate the therapeutic efficacy of silibinin (SLB)-loaded folic acid (FA)-conjugated Pluronic F127 (SLB-F127-FA) nanomicelles as an active-targeted drug delivery platform for liver cancer treatment. To prepare SLB-F127-FA nanomicelles, folic acid was first conjugated to hydrophilic chains of Pluronic F127 copolymer by the Steglich esterification technique. Then, silibinin was encapsulated in the self-assembled hydrophobic core of FA-conjugated F127 to render SLB-F127-FA nanomicelles. The prepared nano micelles had an almost spherical shape with an average particle size of 17.7 nm. The average hydrodynamic size of non-targeted (SLB-F127) and targeted (SLB-F127-FA) nanomicelles, measured by dynamic light scattering analysis (DLS), was 19.6 and 29.2 nm, respectively. Also, the drug loading content as well as entrapment efficiency of SLB-F127-FA nanomicelles were obtained to be 2.36% and 79.43%, respectively. The in vitro release patterns of SLB from nanomicelles showed a slow and sustained release behavior in comparison to free SLB. Moreover, it was observed that the kinetic release of silibinin from the SLB-F127-FA nanomicelles at 37 °C conforms well to Korsmeyer-Peppas kinetic model (R 2 = 0.99, n = 0.22), suggesting a dominate release mechanism of the Fickian diffusion type. Moreover, in vitro cytotoxic study indicated that the viability of human liver cancer cells (HepG2) exposed to SLB-PF127-FA nanomicelles was significantly lower than that of treated with non-targeted nanomicelles (SLB-F127) or free SLB. Our results suggest that SLB-F127-FA nanomicelles can be considered as a promising targeted drug delivery platform for liver cancer therapy and/or delivering other hydrophobic drugs to different types of cancers with folate-receptor overexpression.

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Handbook of Research on Diverse Applications of Nanotechnology in Biomedicine, Chemistry, and Engineering	Handbook of Research on Diverse Applications of Nanotechnology in Biomedicine, Chemistry, and Engineering, 1, 3.13% Handbook of Research on Diverse Applications of Nanotechnology in Biomedicine, Chemistry, and Engineering 1 publication, 3.13%
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Frontiers in Pharmacology	Frontiers in Pharmacology, 1, 3.13% Frontiers in Pharmacology 1 publication, 3.13%
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Elsevier	Elsevier, 6, 18.75% Elsevier 6 publications, 18.75%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 4, 12.5% Multidisciplinary Digital Publishing Institute (MDPI) 4 publications, 12.5%
Wiley	Wiley, 4, 12.5% Wiley 4 publications, 12.5%
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IGI Global	IGI Global, 1, 3.13% IGI Global 1 publication, 3.13%
Taylor & Francis	Taylor & Francis, 1, 3.13% Taylor & Francis 1 publication, 3.13%
American Chemical Society (ACS)	American Chemical Society (ACS), 1, 3.13% American Chemical Society (ACS) 1 publication, 3.13%
Frontiers Media S.A.	Frontiers Media S.A., 1, 3.13% Frontiers Media S.A. 1 publication, 3.13%
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Ghalehkhondabi V., Soleymani M., Fazlali A. Folate-targeted nanomicelles containing silibinin as an active drug delivery system for liver cancer therapy // Journal of Drug Delivery Science and Technology. 2021. Vol. 61. p. 102157.

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TY - JOUR

DO - 10.1016/j.jddst.2020.102157

UR - https://doi.org/10.1016%2Fj.jddst.2020.102157

TI - Folate-targeted nanomicelles containing silibinin as an active drug delivery system for liver cancer therapy

T2 - Journal of Drug Delivery Science and Technology

AU - Ghalehkhondabi, Vahab

AU - Soleymani, Meysam

AU - Fazlali, Alireza

PY - 2021

DA - 2021/02/01 00:00:00

PB - Elsevier

SP - 102157

VL - 61

SN - 1773-2247

SN - 2588-8943

ER -

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@article{2021_Ghalehkhondabi,

author = {Vahab Ghalehkhondabi and Meysam Soleymani and Alireza Fazlali},

title = {Folate-targeted nanomicelles containing silibinin as an active drug delivery system for liver cancer therapy},

journal = {Journal of Drug Delivery Science and Technology},

year = {2021},

volume = {61},

publisher = {Elsevier},

month = {feb},

url = {https://doi.org/10.1016%2Fj.jddst.2020.102157},

pages = {102157},

doi = {10.1016/j.jddst.2020.102157}

}

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Publisher

Elsevier

Journal

Journal of Drug Delivery Science and Technology

Quartile SCImago

Quartile WOS

Impact factor

ISSN

17732247 (Print)
25888943 (Electronic)