Journal of Inorganic Biochemistry, volume 175, pages 190-197
New copper(II) thiohydantoin complexes: Synthesis, characterization, and assessment of their interaction with bovine serum albumin and DNA
Tishchenko Ksenia
1
,
Proskurnin Mikhail A.
2
,
Malinnikov Vladislav
1
,
Guk Dmitriy
1
,
Muratova Marina
1
,
Udina Anna
1
,
Skvortsov Dmitry
1
,
Shafikov Radik R
3
,
Ivanenkov Yan
4, 5
,
A. Aladinskiy Vladimir
6
,
Sorokin Ivan
1
,
Gromov O I
1
,
Zyk Nikolay
1
1
5
Publication type: Journal Article
Publication date: 2017-10-01
Journal:
Journal of Inorganic Biochemistry
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 3.9
ISSN: 01620134, 18733344
Biochemistry
Inorganic Chemistry
Abstract
New copper(II) complexes of 2-alkylthio-5-arylmethylene-4H-imidazolin-4-ones: (5Z)-2-(methylsulfanyl)-3-(prop-2-en-1-yl)-5-(pyridin-2-ylmethylidene)-3,5-dihydro-4H-imidazol-4-one) (1a), (5Z,5'Z)-2,2'-(ethan-1,2-diyldisulfanyldiyl)bis(5-(2-pyridilmethylen)-3-allyl-3,5-dihydo-4Н-imidazole-4-one) (2a) and (5Z,5'Z)-3,3'-hexan-1,6-diylbis[5-(2-pyridilmethylen)-2-methylthiotetrahydro-4Н-imidazole-4-one)] (3a) were synthesized as possible anticancer drugs. Their structures were characterized by 1H NMR spectroscopy, elemental analysis, and X-ray crystallography. The composition of the complexes were found for 1a (Cu:L=1:1), 2a (Cu:L=2:1), and 3a (Cu:L=2:1). The chelation constants were found by competitive complexation with ethylenediamine tetraacetate: 1a (6.7±0.6)×1015M-1, 2a=(4.9±0.4)×1019M-2, and 3a (5.7±0.5)×1019M-2. Supramolecular binding with calf thymus DNA by competitive ethidium bromide quenching was made for complex 2a as the most promising anticancer model, the Stern-Volmer constants were found to be KSV=(8.0±0.4)×106M-1, Kq=(6.5±0.4)×105M-1. The binding of the complex 2a to BSA was made by the Scatchard method, the value of the constant is Kb=(1.9±0.2)×106M-1.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Tishchenko K. et al. New copper(II) thiohydantoin complexes: Synthesis, characterization, and assessment of their interaction with bovine serum albumin and DNA // Journal of Inorganic Biochemistry. 2017. Vol. 175. pp. 190-197.
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Tishchenko K., Beloglazkina E. K., Proskurnin M. A., Malinnikov V., Guk D., Muratova M., Krasnovskaya O. O., Udina A., Skvortsov D., Shafikov R. R., Ivanenkov Y., A. Aladinskiy V., Sorokin I., Gromov O. I., Majouga A. G., Zyk N. New copper(II) thiohydantoin complexes: Synthesis, characterization, and assessment of their interaction with bovine serum albumin and DNA // Journal of Inorganic Biochemistry. 2017. Vol. 175. pp. 190-197.
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TY - JOUR
DO - 10.1016/j.jinorgbio.2017.07.015
UR - https://doi.org/10.1016%2Fj.jinorgbio.2017.07.015
TI - New copper(II) thiohydantoin complexes: Synthesis, characterization, and assessment of their interaction with bovine serum albumin and DNA
T2 - Journal of Inorganic Biochemistry
AU - Tishchenko, Ksenia
AU - Proskurnin, Mikhail A.
AU - Malinnikov, Vladislav
AU - Guk, Dmitriy
AU - Muratova, Marina
AU - Udina, Anna
AU - Sorokin, Ivan
AU - Gromov, O I
AU - Zyk, Nikolay
AU - Beloglazkina, Elena K.
AU - Krasnovskaya, Olga O.
AU - Skvortsov, Dmitry
AU - Shafikov, Radik R
AU - Ivanenkov, Yan
AU - A. Aladinskiy, Vladimir
AU - Majouga, Alexander G.
PY - 2017
DA - 2017/10/01 00:00:00
PB - Elsevier
SP - 190-197
VL - 175
SN - 0162-0134
SN - 1873-3344
ER -
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@article{2017_Tishchenko,
author = {Ksenia Tishchenko and Mikhail A. Proskurnin and Vladislav Malinnikov and Dmitriy Guk and Marina Muratova and Anna Udina and Ivan Sorokin and O I Gromov and Nikolay Zyk and Elena K. Beloglazkina and Olga O. Krasnovskaya and Dmitry Skvortsov and Radik R Shafikov and Yan Ivanenkov and Vladimir A. Aladinskiy and Alexander G. Majouga},
title = {New copper(II) thiohydantoin complexes: Synthesis, characterization, and assessment of their interaction with bovine serum albumin and DNA},
journal = {Journal of Inorganic Biochemistry},
year = {2017},
volume = {175},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016%2Fj.jinorgbio.2017.07.015},
pages = {190--197},
doi = {10.1016/j.jinorgbio.2017.07.015}
}