Journal of Inorganic Biochemistry, volume 218, pages 111394

BODIPY-based monofunctional Pt (II) complexes for specific photocytotoxicity against cancer cells.

Qi Fen ¹

Yuan Hao ^{2, 3}

Chen Yuncong ^{2, 4}

Guo Yan ¹

Zhang Shuren ¹

Liu Zhipeng ⁵

He Weijiang ⁶

Guo Zijian ^{2, 4}

Hide authors affiliations Show authors affiliations: 6 affiliations

State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China. |

State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China |

Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing 210023, China. |

⁴

Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing 210023, China. Electronic address: |

⁵

College of Materials Science and Engineering, Nanjing Forestry University, Nanjing 210073, China. |

⁶

State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China. Electronic address: |

Publication type: Journal Article

Publication date: 2021-05-01

Elsevier

Journal: Journal of Inorganic Biochemistry

Quartile SCImago

Quartile WOS

Impact factor: 3.9

ISSN: 01620134, 18733344

DOI: 10.1016/j.jinorgbio.2021.111394

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Biochemistry

Inorganic Chemistry

Abstract

Photodynamic therapy (PDT) has attracted extensive attention in cancer treatment because of its minimum trauma, less side effects, and so on. Photosensitizers, as one of the core elements of PDT, usually have to face problems such as poor water solubility and light stability, lack of targeting, and other problems, which seriously affect the therapeutic effect. In this work, two BODIPY (boron-dipyrromethene)-based monofunctional Pt (II) complexes, 1a and 2a, were designed and synthesized, and their PDT effect was studied. The Pt atom improved the singlet oxygen quantum yield (0.19 for 1a and 0.14 for 2a, respectively), which effectively improves the efficiency of PDT. MTT assay confirmed that the short time photo-irradiation distinctly promoted antitumor cytotoxicity of Pt (II) compounds against different cell lines. For 1a under irradiation, the IC50 value of cancer cell lines were 13.1 μM for HeLa cells and 7.6 μM for MCF-7 cells, while those of normal cell lines were 32.4 μM for HBL-100 cells and 48.6 μM for L02 cells. The results demonstrated that 1a showed specific phototoxicity to cancer cells. This specific selectivity could be attributed to the synergistic effect of increased cellular uptake (determined by ICP-MS) and higher ROS generation (detected by Cell ROX Deep Red) in cancer cells after irradiation. This study laid the foundation for the future design and synthesis of effective PDT photosensitizers.

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Applied Organometallic Chemistry	Applied Organometallic Chemistry, 1, 5.88% Applied Organometallic Chemistry 1 publication, 5.88%
ACS applied materials & interfaces	ACS applied materials & interfaces, 1, 5.88% ACS applied materials & interfaces 1 publication, 5.88%
Bioorganic Chemistry	Bioorganic Chemistry, 1, 5.88% Bioorganic Chemistry 1 publication, 5.88%
Journal of Medicinal Chemistry	Journal of Medicinal Chemistry, 1, 5.88% Journal of Medicinal Chemistry 1 publication, 5.88%
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Citations by publishers

	1 2 3 4 5
Elsevier	Elsevier, 5, 29.41% Elsevier 5 publications, 29.41%
American Chemical Society (ACS)	American Chemical Society (ACS), 4, 23.53% American Chemical Society (ACS) 4 publications, 23.53%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 3, 17.65% Multidisciplinary Digital Publishing Institute (MDPI) 3 publications, 17.65%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 2, 11.76% Royal Society of Chemistry (RSC) 2 publications, 11.76%
American Scientific Publishers	American Scientific Publishers, 1, 5.88% American Scientific Publishers 1 publication, 5.88%
Bentham Science	Bentham Science, 1, 5.88% Bentham Science 1 publication, 5.88%
Wiley	Wiley, 1, 5.88% Wiley 1 publication, 5.88%
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Qi F. et al. BODIPY-based monofunctional Pt (II) complexes for specific photocytotoxicity against cancer cells. // Journal of Inorganic Biochemistry. 2021. Vol. 218. p. 111394.

GOST all authors (up to 50) Copy

Qi F., Yuan H., Chen Y., Guo Y., Zhang S., Liu Z., He W., Guo Z. BODIPY-based monofunctional Pt (II) complexes for specific photocytotoxicity against cancer cells. // Journal of Inorganic Biochemistry. 2021. Vol. 218. p. 111394.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.jinorgbio.2021.111394

UR - https://doi.org/10.1016%2Fj.jinorgbio.2021.111394

TI - BODIPY-based monofunctional Pt (II) complexes for specific photocytotoxicity against cancer cells.

T2 - Journal of Inorganic Biochemistry

AU - Qi, Fen

AU - Yuan, Hao

AU - Chen, Yuncong

AU - Guo, Yan

AU - Zhang, Shuren

AU - Liu, Zhipeng

AU - He, Weijiang

AU - Guo, Zijian

PY - 2021

DA - 2021/05/01 00:00:00

PB - Elsevier

SP - 111394

VL - 218

SN - 0162-0134

SN - 1873-3344

ER -

BibTex

Cite this

BibTex Copy

@article{2021_Qi,

author = {Fen Qi and Hao Yuan and Yuncong Chen and Yan Guo and Shuren Zhang and Zhipeng Liu and Weijiang He and Zijian Guo},

title = {BODIPY-based monofunctional Pt (II) complexes for specific photocytotoxicity against cancer cells.},

journal = {Journal of Inorganic Biochemistry},

year = {2021},

volume = {218},

publisher = {Elsevier},

month = {may},

url = {https://doi.org/10.1016%2Fj.jinorgbio.2021.111394},

pages = {111394},

doi = {10.1016/j.jinorgbio.2021.111394}

}

Found error?

Publisher

Elsevier

Journal

Journal of Inorganic Biochemistry

Quartile SCImago

Quartile WOS

Impact factor

3.9

ISSN

01620134 (Print)
18733344 (Electronic)