Journal of Inorganic Biochemistry, volume 218, pages 111394
BODIPY-based monofunctional Pt (II) complexes for specific photocytotoxicity against cancer cells.
Qi Fen
1
,
Yuan Hao
2, 3
,
Chen Yuncong
2, 4
,
Guo Yan
1
,
Zhang Shuren
1
,
Liu Zhipeng
5
,
He Weijiang
6
,
Guo Zijian
2, 4
5
Publication type: Journal Article
Publication date: 2021-05-01
Journal:
Journal of Inorganic Biochemistry
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 3.9
ISSN: 01620134, 18733344
Biochemistry
Inorganic Chemistry
Abstract
Photodynamic therapy (PDT) has attracted extensive attention in cancer treatment because of its minimum trauma, less side effects, and so on. Photosensitizers, as one of the core elements of PDT, usually have to face problems such as poor water solubility and light stability, lack of targeting, and other problems, which seriously affect the therapeutic effect. In this work, two BODIPY (boron-dipyrromethene)-based monofunctional Pt (II) complexes, 1a and 2a, were designed and synthesized, and their PDT effect was studied. The Pt atom improved the singlet oxygen quantum yield (0.19 for 1a and 0.14 for 2a, respectively), which effectively improves the efficiency of PDT. MTT assay confirmed that the short time photo-irradiation distinctly promoted antitumor cytotoxicity of Pt (II) compounds against different cell lines. For 1a under irradiation, the IC50 value of cancer cell lines were 13.1 μM for HeLa cells and 7.6 μM for MCF-7 cells, while those of normal cell lines were 32.4 μM for HBL-100 cells and 48.6 μM for L02 cells. The results demonstrated that 1a showed specific phototoxicity to cancer cells. This specific selectivity could be attributed to the synergistic effect of increased cellular uptake (determined by ICP-MS) and higher ROS generation (detected by Cell ROX Deep Red) in cancer cells after irradiation. This study laid the foundation for the future design and synthesis of effective PDT photosensitizers.
Citations by journals
1
2
|
|
Molecules
|
Molecules
2 publications, 11.76%
|
Journal of Biomaterials and Tissue Engineering
|
Journal of Biomaterials and Tissue Engineering
1 publication, 5.88%
|
Current Chinese Science
|
Current Chinese Science
1 publication, 5.88%
|
International Journal of Molecular Sciences
|
International Journal of Molecular Sciences
1 publication, 5.88%
|
Dyes and Pigments
|
Dyes and Pigments
1 publication, 5.88%
|
Journal of Molecular Structure
|
Journal of Molecular Structure
1 publication, 5.88%
|
European Journal of Medicinal Chemistry Reports
|
European Journal of Medicinal Chemistry Reports
1 publication, 5.88%
|
Coordination Chemistry Reviews
|
Coordination Chemistry Reviews
1 publication, 5.88%
|
Dalton Transactions
|
Dalton Transactions
1 publication, 5.88%
|
Journal of Physical Chemistry A
|
Journal of Physical Chemistry A
1 publication, 5.88%
|
New Journal of Chemistry
|
New Journal of Chemistry
1 publication, 5.88%
|
Applied Organometallic Chemistry
|
Applied Organometallic Chemistry
1 publication, 5.88%
|
ACS applied materials & interfaces
|
ACS applied materials & interfaces
1 publication, 5.88%
|
Bioorganic Chemistry
|
Bioorganic Chemistry
1 publication, 5.88%
|
Journal of Medicinal Chemistry
|
Journal of Medicinal Chemistry
1 publication, 5.88%
|
Inorganic Chemistry
|
Inorganic Chemistry
1 publication, 5.88%
|
1
2
|
Citations by publishers
1
2
3
4
5
|
|
Elsevier
|
Elsevier
5 publications, 29.41%
|
American Chemical Society (ACS)
|
American Chemical Society (ACS)
4 publications, 23.53%
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
3 publications, 17.65%
|
Royal Society of Chemistry (RSC)
|
Royal Society of Chemistry (RSC)
2 publications, 11.76%
|
American Scientific Publishers
|
American Scientific Publishers
1 publication, 5.88%
|
Bentham Science
|
Bentham Science
1 publication, 5.88%
|
Wiley
|
Wiley
1 publication, 5.88%
|
1
2
3
4
5
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2021,2022,2023,2024],"ids":[0,0,0,0],"codes":[0,0,0,0],"imageUrls":["","","",""],"datasets":[{"label":"Citations number","data":[3,7,4,3],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["17.65","41.18","23.53","17.65"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Molecules","Journal of Biomaterials and Tissue Engineering","Current Chinese Science","International Journal of Molecular Sciences","Dyes and Pigments","Journal of Molecular Structure","European Journal of Medicinal Chemistry Reports","Coordination Chemistry Reviews","Dalton Transactions","Journal of Physical Chemistry A","New Journal of Chemistry","Applied Organometallic Chemistry","ACS applied materials & interfaces","Bioorganic Chemistry","Journal of Medicinal Chemistry","Inorganic Chemistry"],"ids":[1770,26589,32036,14627,10101,9347,33269,13437,8473,15255,1404,11683,1458,4196,3673,24714],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/3RKsjkHc38X9y2xwqEEGp02jSMcYwvDgfDB3LdnI_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp"],"datasets":[{"label":"","data":[2,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[11.76,5.88,5.88,5.88,5.88,5.88,5.88,5.88,5.88,5.88,5.88,5.88,5.88,5.88,5.88,5.88],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Elsevier","American Chemical Society (ACS)","Multidisciplinary Digital Publishing Institute (MDPI)","Royal Society of Chemistry (RSC)","American Scientific Publishers","Bentham Science","Wiley"],"ids":[17,40,202,123,679,39,11],"codes":[0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/3RKsjkHc38X9y2xwqEEGp02jSMcYwvDgfDB3LdnI_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp"],"datasets":[{"label":"","data":[5,4,3,2,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[29.41,23.53,17.65,11.76,5.88,5.88,5.88],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex
Cite this
GOST
Copy
Qi F. et al. BODIPY-based monofunctional Pt (II) complexes for specific photocytotoxicity against cancer cells. // Journal of Inorganic Biochemistry. 2021. Vol. 218. p. 111394.
GOST all authors (up to 50)
Copy
Qi F., Yuan H., Chen Y., Guo Y., Zhang S., Liu Z., He W., Guo Z. BODIPY-based monofunctional Pt (II) complexes for specific photocytotoxicity against cancer cells. // Journal of Inorganic Biochemistry. 2021. Vol. 218. p. 111394.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.jinorgbio.2021.111394
UR - https://doi.org/10.1016%2Fj.jinorgbio.2021.111394
TI - BODIPY-based monofunctional Pt (II) complexes for specific photocytotoxicity against cancer cells.
T2 - Journal of Inorganic Biochemistry
AU - Qi, Fen
AU - Yuan, Hao
AU - Chen, Yuncong
AU - Guo, Yan
AU - Zhang, Shuren
AU - Liu, Zhipeng
AU - He, Weijiang
AU - Guo, Zijian
PY - 2021
DA - 2021/05/01 00:00:00
PB - Elsevier
SP - 111394
VL - 218
SN - 0162-0134
SN - 1873-3344
ER -
Cite this
BibTex
Copy
@article{2021_Qi,
author = {Fen Qi and Hao Yuan and Yuncong Chen and Yan Guo and Shuren Zhang and Zhipeng Liu and Weijiang He and Zijian Guo},
title = {BODIPY-based monofunctional Pt (II) complexes for specific photocytotoxicity against cancer cells.},
journal = {Journal of Inorganic Biochemistry},
year = {2021},
volume = {218},
publisher = {Elsevier},
month = {may},
url = {https://doi.org/10.1016%2Fj.jinorgbio.2021.111394},
pages = {111394},
doi = {10.1016/j.jinorgbio.2021.111394}
}