Journal of Molecular Biology, volume 355, issue 5, pages 1014-1025
A Pathway for the Transmission of Allosteric Signals in the Ribosome through a Network of RNA Tertiary Interactions
1
Department of Biochemistry and Molecular Biology The University of Chicago Chicago IL 60637 USA
|
Publication type: Journal Article
Publication date: 2006-02-01
Journal:
Journal of Molecular Biology
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.6
ISSN: 00222836, 10898638
Molecular Biology
Structural Biology
Abstract
There are a large number of tertiary contacts between nucleotides in 23S rRNA, but which are of functional importance is not known. Disruption of one between A2662 in the sarcin/ricin loop (SRL) and A2531 in the peptidyl-transferase center (PTC) has adverse effects on cell growth and on the ability of ribosomes to catalyze some but not other partial reactions of elongation. A lethal A2662C mutation is suppressed by a concomitant lethal A2531 mutation. Ribosomes with non-lethal A2531 mutations, treated with base-specific reagents, have alterations of nucleotides in the PTC (home of A2531) and, more significantly, in nucleotides in the SRL and in the GTPase center. The results suggest that the function of ribosomal centers is coordinated by a set of sequential conformational changes in rRNA that are a response to signals transmitted through a network of tertiary interactions.
Citations by journals
|
1
2
3
|
|
|
Nucleic Acids Research
|
Nucleic Acids Research
3 publications, 15.79%
|
|
RNA
|
RNA
2 publications, 10.53%
|
|
Molecular Biology
|
Molecular Biology
2 publications, 10.53%
|
|
Biochemistry (Moscow)
|
Biochemistry (Moscow)
2 publications, 10.53%
|
|
FEBS Letters
|
FEBS Letters
1 publication, 5.26%
|
|
Scientific Reports
|
Scientific Reports
1 publication, 5.26%
|
|
Nature Chemical Biology
|
Nature Chemical Biology
1 publication, 5.26%
|
|
Biochimie
|
Biochimie
1 publication, 5.26%
|
|
Journal of Molecular Biology
|
Journal of Molecular Biology
1 publication, 5.26%
|
|
Biochimica et Biophysica Acta - General Subjects
|
Biochimica et Biophysica Acta - General Subjects
1 publication, 5.26%
|
|
IEEE Nanotechnology Magazine
|
IEEE Nanotechnology Magazine
1 publication, 5.26%
|
|
Advances in Genetics
|
Advances in Genetics
1 publication, 5.26%
|
|
EcoSal Plus
|
EcoSal Plus
1 publication, 5.26%
|
|
Proceedings of the National Academy of Sciences of the United States of America
|
Proceedings of the National Academy of Sciences of the United States of America
1 publication, 5.26%
|
|
1
2
3
|
Citations by publishers
|
1
2
3
4
|
|
|
Pleiades Publishing
|
Pleiades Publishing
4 publications, 21.05%
|
|
Elsevier
|
Elsevier
4 publications, 21.05%
|
|
Oxford University Press
|
Oxford University Press
3 publications, 15.79%
|
|
Cold Spring Harbor Laboratory
|
Cold Spring Harbor Laboratory
2 publications, 10.53%
|
|
Springer Nature
|
Springer Nature
2 publications, 10.53%
|
|
Wiley
|
Wiley
1 publication, 5.26%
|
|
IEEE
|
IEEE
1 publication, 5.26%
|
|
American Society for Microbiology
|
American Society for Microbiology
1 publication, 5.26%
|
|
Proceedings of the National Academy of Sciences (PNAS)
|
Proceedings of the National Academy of Sciences (PNAS)
1 publication, 5.26%
|
|
1
2
3
4
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2006,2007,2008,2009,2010,2011,2012,2013,2014,2015,2016,2017,2018,2019],"ids":[0,0,0,0,0,0,0,0,0,0,0,0,0,0],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["","","","","","","","","","","","","",""],"datasets":[{"label":"Citations number","data":[1,3,1,4,2,1,0,0,1,1,1,3,0,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["5.26","15.79","5.26","21.05","10.53","5.26",0,0,"5.26","5.26","5.26","15.79",0,"5.26"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Nucleic Acids Research","RNA","Molecular Biology","Biochemistry (Moscow)","FEBS Letters","Scientific Reports","Nature Chemical Biology","Biochimie","Journal of Molecular Biology","Biochimica et Biophysica Acta - General Subjects","IEEE Nanotechnology Magazine","Advances in Genetics","EcoSal Plus","Proceedings of the National Academy of Sciences of the United States of America"],"ids":[23904,12892,1134,2119,405,13767,17718,4794,19701,5266,16468,15350,12012,306],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/hg4jJjT8wVGtHstBCc0zk465Mg9pLx3G4odCDOqE_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/6scCJegesojp2jubwY3uKCzTAmgsaH2GIFlg6Hfk_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/VPE7q24PXoHr5SS2SqfEgxccSMUxWLfZINOX60uo_medium.webp","\/storage\/images\/resized\/mxFdPe9qujsfvfYfcN0QOclAiYORFb0xrRlwV8gs_medium.webp"],"datasets":[{"label":"","data":[3,2,2,2,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[15.79,10.53,10.53,10.53,5.26,5.26,5.26,5.26,5.26,5.26,5.26,5.26,5.26,5.26],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Pleiades Publishing","Elsevier","Oxford University Press","Cold Spring Harbor Laboratory","Springer Nature","Wiley","IEEE","American Society for Microbiology","Proceedings of the National Academy of Sciences (PNAS)"],"ids":[101,17,19,6909,8,11,6953,142,162],"codes":[0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/hg4jJjT8wVGtHstBCc0zk465Mg9pLx3G4odCDOqE_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/6scCJegesojp2jubwY3uKCzTAmgsaH2GIFlg6Hfk_medium.webp","\/storage\/images\/resized\/VPE7q24PXoHr5SS2SqfEgxccSMUxWLfZINOX60uo_medium.webp","\/storage\/images\/resized\/mxFdPe9qujsfvfYfcN0QOclAiYORFb0xrRlwV8gs_medium.webp"],"datasets":[{"label":"","data":[4,4,3,2,2,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[21.05,21.05,15.79,10.53,10.53,5.26,5.26,5.26,5.26],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
CHAN Y., Dresios J., Wool I. G. A Pathway for the Transmission of Allosteric Signals in the Ribosome through a Network of RNA Tertiary Interactions // Journal of Molecular Biology. 2006. Vol. 355. No. 5. pp. 1014-1025.
GOST all authors (up to 50)
Copy
CHAN Y., Dresios J., Wool I. G. A Pathway for the Transmission of Allosteric Signals in the Ribosome through a Network of RNA Tertiary Interactions // Journal of Molecular Biology. 2006. Vol. 355. No. 5. pp. 1014-1025.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.jmb.2005.11.037
UR - https://doi.org/10.1016%2Fj.jmb.2005.11.037
TI - A Pathway for the Transmission of Allosteric Signals in the Ribosome through a Network of RNA Tertiary Interactions
T2 - Journal of Molecular Biology
AU - CHAN, YUEN-LING
AU - Dresios, John
AU - Wool, Ira G.
PY - 2006
DA - 2006/02/01 00:00:00
PB - Elsevier
SP - 1014-1025
IS - 5
VL - 355
SN - 0022-2836
SN - 1089-8638
ER -
Cite this
BibTex
Copy
@article{2006_CHAN,
author = {YUEN-LING CHAN and John Dresios and Ira G. Wool},
title = {A Pathway for the Transmission of Allosteric Signals in the Ribosome through a Network of RNA Tertiary Interactions},
journal = {Journal of Molecular Biology},
year = {2006},
volume = {355},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016%2Fj.jmb.2005.11.037},
number = {5},
pages = {1014--1025},
doi = {10.1016/j.jmb.2005.11.037}
}
Cite this
MLA
Copy
CHAN, YUEN-LING, et al. “A Pathway for the Transmission of Allosteric Signals in the Ribosome through a Network of RNA Tertiary Interactions.” Journal of Molecular Biology, vol. 355, no. 5, Feb. 2006, pp. 1014-1025. https://doi.org/10.1016%2Fj.jmb.2005.11.037.