Journal of Molecular Biology, volume 431, issue 18, pages 3520-3530
Docking on Lipid II—A Widespread Mechanism for Potent Bactericidal Activities of Antibiotic Peptides
1
Institute for Pharmaceutical Microbiology, University of Bonn, Bonn, Germany
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2
German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Bonn, Germany.
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Publication type: Journal Article
Publication date: 2019-08-01
Journal:
Journal of Molecular Biology
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.6
ISSN: 00222836, 10898638
Molecular Biology
Structural Biology
Abstract
Natural product antibiotics usually target the major biosynthetic pathways of bacterial cells and the search for new targets outside these pathways has proven very difficult. Cell wall biosynthesis maybe the most prominent antibiotic target, and ß-lactams are among the clinically most relevant antibiotics. Among cell wall biosynthesis inhibitors, glycopeptide antibiotics are a second group of important drugs, which bind to the peptidoglycan building block lipid II and prevent the incorporation of the monomeric unit into polymeric cell wall. However, lipid II acts as a docking molecule for many more naturally occurring antibiotics from diverse chemical classes and likely is the most targeted molecule in antibacterial mechanisms. We summarize current knowledge on lipid II binding antibiotics and explain, on the levels of mechanisms and resistance development, why lipid II is such a prominent target, and thus provide insights for the design of new antibiotic drugs.
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Citations by publishers
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Grein F. et al. Docking on Lipid II—A Widespread Mechanism for Potent Bactericidal Activities of Antibiotic Peptides // Journal of Molecular Biology. 2019. Vol. 431. No. 18. pp. 3520-3530.
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Grein F., Schneider T., SAHL H. Docking on Lipid II—A Widespread Mechanism for Potent Bactericidal Activities of Antibiotic Peptides // Journal of Molecular Biology. 2019. Vol. 431. No. 18. pp. 3520-3530.
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TY - JOUR
DO - 10.1016/j.jmb.2019.05.014
UR - https://doi.org/10.1016%2Fj.jmb.2019.05.014
TI - Docking on Lipid II—A Widespread Mechanism for Potent Bactericidal Activities of Antibiotic Peptides
T2 - Journal of Molecular Biology
AU - Grein, Fabian
AU - Schneider, Tanja
AU - SAHL, HANS-GEORG
PY - 2019
DA - 2019/08/01 00:00:00
PB - Elsevier
SP - 3520-3530
IS - 18
VL - 431
SN - 0022-2836
SN - 1089-8638
ER -
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@article{2019_Grein,
author = {Fabian Grein and Tanja Schneider and HANS-GEORG SAHL},
title = {Docking on Lipid II—A Widespread Mechanism for Potent Bactericidal Activities of Antibiotic Peptides},
journal = {Journal of Molecular Biology},
year = {2019},
volume = {431},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016%2Fj.jmb.2019.05.014},
number = {18},
pages = {3520--3530},
doi = {10.1016/j.jmb.2019.05.014}
}
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MLA
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Grein, Fabian, et al. “Docking on Lipid II—A Widespread Mechanism for Potent Bactericidal Activities of Antibiotic Peptides.” Journal of Molecular Biology, vol. 431, no. 18, Aug. 2019, pp. 3520-3530. https://doi.org/10.1016%2Fj.jmb.2019.05.014.