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Journal of Pharmaceutical Analysis, том 11, издание 2, номера страниц: 241-250

Diversity, novelty, antimicrobial activity, and new antibiotics of cultivable endophytic actinobacteria isolated from psammophytes collected from Taklamakan Desert

Liu Shaowei
Wu Gang
Jiang Zhongke
Li Feina
Lu Qinpei
Habden Xugela
Hu Xinxin
You Xuefu
Wang Ting
Тип документаJournal Article
Дата публикации2021-01-01
ИздательXi'an Jiaotong University
Название журналаJournal of Pharmaceutical Analysis
Квартиль по SCImagoQ1
Квартиль по Web of ScienceQ1
Импакт-фактор 202114.03
Drug Discovery
Pharmaceutical Science
Analytical Chemistry
Краткое описание
Three hundred and twenty endophytic actinobacterial strains were isolated from psammophytes collected from Taklamakan Desert and identified. Among them, three strains already had been identified as new species of two genera and sixteen isolates showed relatively low 16S rRNA similarities < 98.6% to validly described species. Seventy-five of the isolates were selected as representative strains to screen antibacterial activity and mechanism. Forty-seven strains showed antagonistic activity against at least one of the indicator bacteria. Two Streptomyces strains produced bioactive compounds inducing DNA damage, and two Streptomyces strains produced bioactive compounds with inhibitory activity on protein biosynthesis. Notably, the strain Streptomyces sp. 8P21H-1 that demonstrated both strong antibacterial activity and inhibitory activity on protein biosynthesis was prioritized for exploring new antibiotics. Under the strategy of integrating genetics-based discovery program and MS/MS-based molecular networking, two new streptogramin-type antibiotics, i.e., acetyl-griseoviridin and desulphurizing griseoviridin, along with known griseoviridin, were isolated from the culture broth of strain 8P21H-1. Their chemical structures were determined by HR-MS, and 1D and 2D NMR. Desulphurizing griseoviridin and griseoviridin exhibited antibacterial activities by inhibiting translation.
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1. Wang T. и др. Diversity, novelty, antimicrobial activity, and new antibiotics of cultivable endophytic actinobacteria isolated from psammophytes collected from Taklamakan Desert // Journal of Pharmaceutical Analysis. 2021. Т. 11. № 2. С. 241–250.


DO - 10.1016/j.jpha.2020.06.004

UR -

TI - Diversity, novelty, antimicrobial activity, and new antibiotics of cultivable endophytic actinobacteria isolated from psammophytes collected from Taklamakan Desert

T2 - Journal of Pharmaceutical Analysis

AU - Wang, Ting

AU - Li, Feina

AU - Lu, Qinpei

AU - Wu, Gang

AU - Jiang, Zhongke

AU - Liu, Shaowei

AU - Habden, Xugela

AU - Razumova, Elizaveta A.

AU - Osterman, Ilya A.

AU - Sergiev, Petr V.

AU - Dontsova, Olga A.

AU - Hu, Xinxin

AU - You, Xuefu

AU - Sun, Chenghang

PY - 2021

DA - 2021/04

PB - Elsevier BV

SP - 241-250

IS - 2

VL - 11

SN - 2095-1779

ER -

BibTex |


doi = {10.1016/j.jpha.2020.06.004},

url = {},

year = 2021,

month = {apr},

publisher = {Elsevier {BV}},

volume = {11},

number = {2},

pages = {241--250},

author = {Ting Wang and Feina Li and Qinpei Lu and Gang Wu and Zhongke Jiang and Shaowei Liu and Xugela Habden and Elizaveta A. Razumova and Ilya A. Osterman and Petr V. Sergiev and Olga A. Dontsova and Xinxin Hu and Xuefu You and Chenghang Sun},

title = {Diversity, novelty, antimicrobial activity, and new antibiotics of cultivable endophytic actinobacteria isolated from psammophytes collected from Taklamakan Desert}


Wang, Ting et al. “Diversity, Novelty, Antimicrobial Activity, and New Antibiotics of Cultivable Endophytic Actinobacteria Isolated from Psammophytes Collected from Taklamakan Desert.” Journal of Pharmaceutical Analysis 11.2 (2021): 241–250. Crossref. Web.