Journal of Photochemistry and Photobiology C: Photochemistry Reviews, volume 40, pages 21-48
BODIPYs in antitumoral and antimicrobial photodynamic therapy: An integrating review
Agazzi Maximiliano L
1
,
Ballatore M Belén
1
,
Durantini Andres
1
,
Durantini Edgardo N.
1
,
Tomé Augusto C.
2
1
Departamento de Química, Facultad de Ciencias Exactas Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Agencia Postal Nro 3, X5804BYA Río Cuarto, Córdoba, Argentina
|
2
QOPNA & LAQV‐REQUIMTE, Department of Chemistry University of Aveiro 3810‐193 Aveiro Portugal
|
Publication type: Journal Article
Publication date: 2019-09-01
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 13.6
ISSN: 13895567
Catalysis
Organic Chemistry
Physical and Theoretical Chemistry
Abstract
Nowadays, both cancer and infections caused by antibiotic resistant microorganisms are problems that affect the entire planet. Phototherapy (namely photodynamic therapy (PDT) and photodynamic inactivation (PDI) of microorganisms) are an alternative method for the treatment of these diseases. That requires adequate photosensitizers and, in this sense, boron-dipyrromethenes (BODIPYs) have interesting properties to act as phototherapeutic agents. In the present review, first, we describe the different strategies used to increase reactive oxygen species production. Then, we explain different architectures developed aiming to enhance the solubility of BODIPYs in biological media in order to optimize their targeting and delivery into the cells to be treated. Finally, we discuss the design of BODIPYs that are activated by specific stimuli present in the target tissues, allowing increasing the selectivity of the treatment. The data presented and discussed here show that BODIPYs are outstanding photosensitizers for the treatment of tumors and infections in the presence of oxygen and light.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Agazzi M. L. et al. BODIPYs in antitumoral and antimicrobial photodynamic therapy: An integrating review // Journal of Photochemistry and Photobiology C: Photochemistry Reviews. 2019. Vol. 40. pp. 21-48.
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Agazzi M. L., Ballatore M. B., Durantini A., Durantini E. N., Tomé A. C. BODIPYs in antitumoral and antimicrobial photodynamic therapy: An integrating review // Journal of Photochemistry and Photobiology C: Photochemistry Reviews. 2019. Vol. 40. pp. 21-48.
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TY - JOUR
DO - 10.1016/j.jphotochemrev.2019.04.001
UR - https://doi.org/10.1016%2Fj.jphotochemrev.2019.04.001
TI - BODIPYs in antitumoral and antimicrobial photodynamic therapy: An integrating review
T2 - Journal of Photochemistry and Photobiology C: Photochemistry Reviews
AU - Agazzi, Maximiliano L
AU - Ballatore, M Belén
AU - Durantini, Andres
AU - Durantini, Edgardo N.
AU - Tomé, Augusto C.
PY - 2019
DA - 2019/09/01 00:00:00
PB - Elsevier
SP - 21-48
VL - 40
SN - 1389-5567
ER -
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@article{2019_Agazzi,
author = {Maximiliano L Agazzi and M Belén Ballatore and Andres Durantini and Edgardo N. Durantini and Augusto C. Tomé},
title = {BODIPYs in antitumoral and antimicrobial photodynamic therapy: An integrating review},
journal = {Journal of Photochemistry and Photobiology C: Photochemistry Reviews},
year = {2019},
volume = {40},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016%2Fj.jphotochemrev.2019.04.001},
pages = {21--48},
doi = {10.1016/j.jphotochemrev.2019.04.001}
}