Open Access
Life Sciences, volume 304, pages 120720
Laser-induced singlet oxygen selectively triggers oscillatory mitochondrial permeability transition and apoptosis in melanoma cell lines
Publication type: Journal Article
Publication date: 2022-09-01
Journal:
Life Sciences
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 6.1
ISSN: 00243205, 18790631
General Biochemistry, Genetics and Molecular Biology
General Medicine
General Pharmacology, Toxicology and Pharmaceutics
Abstract
Singlet oxygen (1O2) is an electronically excited state of triplet oxygen which is less stable than molecular oxygen in the electronic ground state and produced by photochemical, thermal, chemical, or enzymatic activation of O2. Although the role of singlet oxygen in biology and medicine was intensively studied with photosensitisers, using of these compounds is limited due to toxicity and lack of selectivity. We generated singlet oxygen in the skin fibroblasts and melanoma cell lines by 1267 nm laser irradiation. It did not induce production of superoxide anion, hydrogen peroxide or activation of lipid peroxidation in these cells confirming high selectivity of 1267 nm laser to singlet oxygen. 1O2 did not change mitochondrial membrane potential (ΔΨm) in skin fibroblasts but induced fluctuation in ΔΨm and complete mitochondrial depolarisation due to opening permeability transition pore in B16 melanoma cells. 1267 nm irradiation did not change the percentage of fibroblasts with necrosis but significantly increased the number of B16 melanoma cells with apoptosis. Thus, singlet oxygen can induce apoptosis in cancer B16 melanoma cells by opening of mitochondrial permeability transition pore (PTP) but not in control fibroblasts.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Novikova I. A. et al. Laser-induced singlet oxygen selectively triggers oscillatory mitochondrial permeability transition and apoptosis in melanoma cell lines // Life Sciences. 2022. Vol. 304. p. 120720.
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Novikova I. A., Potapova E. V., Dremin V., Dunaev A. V., Abramov A. Y. Laser-induced singlet oxygen selectively triggers oscillatory mitochondrial permeability transition and apoptosis in melanoma cell lines // Life Sciences. 2022. Vol. 304. p. 120720.
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TY - JOUR
DO - 10.1016/j.lfs.2022.120720
UR - https://doi.org/10.1016%2Fj.lfs.2022.120720
TI - Laser-induced singlet oxygen selectively triggers oscillatory mitochondrial permeability transition and apoptosis in melanoma cell lines
T2 - Life Sciences
AU - Novikova, I. A.
AU - Potapova, Elena V.
AU - Dremin, Viktor
AU - Dunaev, Andrey V.
AU - Abramov, Andrey Y
PY - 2022
DA - 2022/09/01 00:00:00
PB - Elsevier
SP - 120720
VL - 304
SN - 0024-3205
SN - 1879-0631
ER -
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@article{2022_Novikova,
author = {I. A. Novikova and Elena V. Potapova and Viktor Dremin and Andrey V. Dunaev and Andrey Y Abramov},
title = {Laser-induced singlet oxygen selectively triggers oscillatory mitochondrial permeability transition and apoptosis in melanoma cell lines},
journal = {Life Sciences},
year = {2022},
volume = {304},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016%2Fj.lfs.2022.120720},
pages = {120720},
doi = {10.1016/j.lfs.2022.120720}
}