Medical Engineering and Physics, volume 37, issue 6, pages 574-583
Individual variability analysis of fluorescence parameters measured in skin with different levels of nutritive blood flow.
Dunaev Andrey V.
1, 2
,
Dremin Victor V.
3
,
Rafailov Ilya E.
4
,
Litvinova Karina
4, 5
,
Palmer Scott G
2
,
Stewart Neil A
4
,
1
Biomedical Photonics Instrumentation Group, Scientific-Educational Center of “Biomedical Engineering”, State University – Education-Science-Production Complex, Oryol 302020, Russia
|
3
Biomedical Photonics Instrumentation Group, Scientific-Educational Center of Biomedical Engineering, State University - Education-Science-Production Complex, Oryol 302020, Russia.
|
4
Publication type: Journal Article
Publication date: 2015-06-01
Journal:
Medical Engineering and Physics
Quartile SCImago
Q3
Quartile WOS
Q3
Impact factor: 2.2
ISSN: 13504533, 18734030
Biophysics
Biomedical Engineering
Abstract
Fluorescence spectroscopy has recently become more common in clinical medicine. However, there are still many unresolved issues related to the methodology and implementation of instruments with this technology. In this study, we aimed to assess individual variability of fluorescence parameters of endogenous markers (NADH, FAD, etc.) measured by fluorescent spectroscopy (FS) in situ and to analyse the factors that lead to a significant scatter of results. Most studied fluorophores have an acceptable scatter of values (mostly up to 30%) for diagnostic purposes. Here we provide evidence that the level of blood volume in tissue impacts FS data with a significant inverse correlation. The distribution function of the fluorescence intensity and the fluorescent contrast coefficient values are a function of the normal distribution for most of the studied fluorophores and the redox ratio. The effects of various physiological (different content of skin melanin) and technical (characteristics of optical filters) factors on the measurement results were additionally studied. The data on the variability of the measurement results in FS should be considered when interpreting the diagnostic parameters, as well as when developing new algorithms for data processing and FS devices.
Citations by journals
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Citations by publishers
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2
4
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12
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16
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SPIE
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15 publications, 32.61%
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American Institute of Physics (AIP)
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IOP Publishing
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1 publication, 2.17%
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Springer Nature
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Springer Nature
1 publication, 2.17%
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Pleiades Publishing
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2
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8
10
12
14
16
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Dunaev A. V. et al. Individual variability analysis of fluorescence parameters measured in skin with different levels of nutritive blood flow. // Medical Engineering and Physics. 2015. Vol. 37. No. 6. pp. 574-583.
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Dunaev A. V., Dremin V. V., Zherebtsov E. A., Rafailov I. E., Litvinova K., Palmer S. G., Stewart N. A., Socolovski S., Rafailov E. Individual variability analysis of fluorescence parameters measured in skin with different levels of nutritive blood flow. // Medical Engineering and Physics. 2015. Vol. 37. No. 6. pp. 574-583.
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TY - JOUR
DO - 10.1016/j.medengphy.2015.03.011
UR - https://doi.org/10.1016%2Fj.medengphy.2015.03.011
TI - Individual variability analysis of fluorescence parameters measured in skin with different levels of nutritive blood flow.
T2 - Medical Engineering and Physics
AU - Dremin, Victor V.
AU - Stewart, Neil A
AU - Rafailov, Ilya E.
AU - Palmer, Scott G
AU - Dunaev, Andrey V.
AU - Zherebtsov, Evgeny A.
AU - Litvinova, Karina
AU - Socolovski, Sergey
AU - Rafailov, Edik
PY - 2015
DA - 2015/06/01 00:00:00
PB - Elsevier
SP - 574-583
IS - 6
VL - 37
SN - 1350-4533
SN - 1873-4030
ER -
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@article{2015_Dunaev,
author = {Victor V. Dremin and Neil A Stewart and Ilya E. Rafailov and Scott G Palmer and Andrey V. Dunaev and Evgeny A. Zherebtsov and Karina Litvinova and Sergey Socolovski and Edik Rafailov},
title = {Individual variability analysis of fluorescence parameters measured in skin with different levels of nutritive blood flow.},
journal = {Medical Engineering and Physics},
year = {2015},
volume = {37},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016%2Fj.medengphy.2015.03.011},
number = {6},
pages = {574--583},
doi = {10.1016/j.medengphy.2015.03.011}
}
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MLA
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Dunaev, Andrey V., et al. “Individual variability analysis of fluorescence parameters measured in skin with different levels of nutritive blood flow..” Medical Engineering and Physics, vol. 37, no. 6, Jun. 2015, pp. 574-583. https://doi.org/10.1016%2Fj.medengphy.2015.03.011.