Molecular Cell, volume 18, issue 1, pages 131-138
Telomere-End Processing
Publication type: Journal Article
Publication date: 2005-04-04
Journal:
Molecular Cell
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 16
ISSN: 10972765, 10974164
Molecular Biology
Cell Biology
Abstract
Mammalian telomeres end in single-stranded, G-rich 3' overhangs resulting from both the "end-replication problem" (the inability of DNA polymerase to replicate the very end of the telomeres) and postreplication processing. Telomeric G-rich overhangs are precisely defined in ciliates; the length and the terminal nucleotides are fixed. Human telomeres have very long overhangs that are heterogeneous in size (35-600 nt), indicating that their processing must differ in some respects from model organisms. We developed telomere-end ligation protocols that allowed us to identify the terminal nucleotides of both the C-rich and the G-rich telomere strands. Up to approximately 80% of the C-rich strands terminate in CCAATC-5', suggesting that after replication a nuclease with high specificity or constrained action acts on the C strand. In contrast, the G-terminal nucleotide was less precise than Tetrahymena and Euplotes but still had a bias that changed as a function of telomerase expression.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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TY - JOUR
DO - 10.1016/j.molcel.2005.02.035
UR - https://doi.org/10.1016%2Fj.molcel.2005.02.035
TI - Telomere-End Processing
T2 - Molecular Cell
AU - Sfeir, Agnel J.
AU - Chai, Weihang
AU - Shay, Jerry W.
AU - Wright, Woodring E.
PY - 2005
DA - 2005/04/04 00:00:00
PB - Elsevier
SP - 131-138
IS - 1
VL - 18
SN - 1097-2765
SN - 1097-4164
ER -
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@article{2005_Sfeir,
author = {Agnel J. Sfeir and Weihang Chai and Jerry W. Shay and Woodring E. Wright},
title = {Telomere-End Processing},
journal = {Molecular Cell},
year = {2005},
volume = {18},
publisher = {Elsevier},
month = {apr},
url = {https://doi.org/10.1016%2Fj.molcel.2005.02.035},
number = {1},
pages = {131--138},
doi = {10.1016/j.molcel.2005.02.035}
}
Cite this
MLA
Copy
Sfeir, Agnel J., et al. “Telomere-End Processing.” Molecular Cell, vol. 18, no. 1, Apr. 2005, pp. 131-138. https://doi.org/10.1016%2Fj.molcel.2005.02.035.