Open Access
Journal of Molecular Liquids, volume 284, pages 215-224
Doxorubicin-loaded biodegradable capsules: Temperature induced shrinking and study of cytotoxicity in vitro
Trushina Daria
1, 2, 3
,
Akasov Roman A.
1, 4
,
Khovankina Anna V
5
,
Borodina Tatiana
1, 3
,
Bukreeva Tatiana V
2, 3
,
Markvicheva E.
5
3
4
Publication type: Journal Article
Publication date: 2019-06-01
Journal:
Journal of Molecular Liquids
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 6
ISSN: 01677322, 18733166
Materials Chemistry
Electronic, Optical and Magnetic Materials
Physical and Theoretical Chemistry
Spectroscopy
Atomic and Molecular Physics, and Optics
Condensed Matter Physics
Abstract
Doxorubicin (DOX) is one of mainstays in anticancer therapy due to its universal anticancer activity. Development of DOX delivery systems is of particular importance aiming a reduction in its non-targeted toxicity and improvement of the treatment efficiency. In this study, biodegradable polyelectrolyte multilayer capsules from a dextran sulfate (DS) and poly- l -arginine (Parg) couple for intracellular DOX delivery has been developed. The capsules were fabricated by layer-by-layer (LbL) technique using vaterite particles (500 ± 100 nm) as sacrificial templates. An elegant approach for simultaneous miniaturization of the capsules down to a size of 290 ± 60 nm and DOX loading was elaborated. Cytotoxicity of the DOX-loaded capsules was evaluated in vitro using human breast adenocarcinoma MCF-7 and DOX-resistant MCF-7/ADR cells. Penetration and accumulation of the capsules in the cells were studied by confocal microscopy and flow cytometry. The pronounced accumulation of the DOX-loaded shrunken capsules in MCF-7/ADR cells suggested overcoming drug resistance. The developed capsules could be promising for both anticancer therapy and diagnostic purposes.
Citations by journals
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1 publication, 3.45%
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1 publication, 3.45%
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1 publication, 3.45%
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1
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Citations by publishers
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2
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6
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10
12
14
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2 publications, 6.9%
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1 publication, 3.45%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 3.45%
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Springer Nature
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Springer Nature
1 publication, 3.45%
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Wiley
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Wiley
1 publication, 3.45%
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Taylor & Francis
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Taylor & Francis
1 publication, 3.45%
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2
4
6
8
10
12
14
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Trushina D. et al. Doxorubicin-loaded biodegradable capsules: Temperature induced shrinking and study of cytotoxicity in vitro // Journal of Molecular Liquids. 2019. Vol. 284. pp. 215-224.
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Trushina D., Akasov R. A., Khovankina A. V., Borodina T., Bukreeva T. V., Markvicheva E. Doxorubicin-loaded biodegradable capsules: Temperature induced shrinking and study of cytotoxicity in vitro // Journal of Molecular Liquids. 2019. Vol. 284. pp. 215-224.
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TY - JOUR
DO - 10.1016/j.molliq.2019.03.152
UR - https://doi.org/10.1016%2Fj.molliq.2019.03.152
TI - Doxorubicin-loaded biodegradable capsules: Temperature induced shrinking and study of cytotoxicity in vitro
T2 - Journal of Molecular Liquids
AU - Trushina, Daria
AU - Akasov, Roman A.
AU - Khovankina, Anna V
AU - Borodina, Tatiana
AU - Bukreeva, Tatiana V
AU - Markvicheva, E.
PY - 2019
DA - 2019/06/01 00:00:00
PB - Elsevier
SP - 215-224
VL - 284
SN - 0167-7322
SN - 1873-3166
ER -
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@article{2019_Trushina,
author = {Daria Trushina and Roman A. Akasov and Anna V Khovankina and Tatiana Borodina and Tatiana V Bukreeva and E. Markvicheva},
title = {Doxorubicin-loaded biodegradable capsules: Temperature induced shrinking and study of cytotoxicity in vitro},
journal = {Journal of Molecular Liquids},
year = {2019},
volume = {284},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016%2Fj.molliq.2019.03.152},
pages = {215--224},
doi = {10.1016/j.molliq.2019.03.152}
}