Open Access

Journal of Molecular Liquids, volume 345, pages 117031

Water-Soluble BODIPY-Based fluorescent probe for BSA and HSA detection

Ksenofontov Alexander A ¹

Bocharov Pavel S ^{2, 3}

Ksenofontova Ksenia V ⁴

Antina Elena V ¹

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G. A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences , 1 Akademicheskaya Street , Ivanovo 153045 , Russia. |

G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences, 1 Akademicheskaya Street, Ivanovo 153045, Russia |

Ivanovo State University of Chemistry and Technology, 7, Sheremetevskiy Avenue, Ivanovo 153000, Russia |

⁴

Ivanovo State University of Chemistry and Technology, 7, Sheremetevskiy Avenue, Ivanovo, 153000, Russia |

Publication type: Journal Article

Publication date: 2022-01-01

Elsevier

Journal: Journal of Molecular Liquids

Quartile SCImago

Quartile WOS

Impact factor: 6

ISSN: 01677322, 18733166

DOI: 10.1016/j.molliq.2021.117031

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Materials Chemistry

Electronic, Optical and Magnetic Materials

Physical and Theoretical Chemistry

Spectroscopy

Atomic and Molecular Physics, and Optics

Condensed Matter Physics

Abstract

• We have developed new BP1 fluorescent probe for selective detection of HSA in urine. • BP1 – SA complexes are formed predominantly due to the specific interactions. • BP1 – SA complex formation is accompanied by a strong BP1 fluorescence quenching. • BP1 fluorescence quenching is realized through FRET. Interaction of 4,4-difluoro-1,3,7,8-tetramethyl-2,6-disulfo-4-bora-3a,4a-diaza- s -indacene sodium salt (BODIPY, BP1 ) with bovine serum albumin (BSA) and human serum albumin (HSA) was investigated using spectral methods and molecular docking. It was shown that BP1 forms stable supramolecular complexes with BSA and HSA predominantly due to the specific interactions. Supramolecular complex formation was accompanied by strong fluorescence quenching of BP1 as a result of FRET. This effect could be used for the qualitative and quantitative detection of HSA in model physiological fluids. The detection limit of BSA and HSA were 0.26 and 0.05 mg·mL −1 , respectively. The selectivity of BP1 fluorescence response to the co-presence of BSA and HSA in solution was demonstrated. The BP1 fluorescent probe was successfully used for the qualitative and quantitative detection of HSA in human urine samples. The obtained results indicated the capability of using BP1 -based fluorescent sensors in clinical medicine for early detection of microalbuminuria and concomitant diseases.

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	1 2 3 4 5 6 7 8 9
Elsevier	Elsevier, 9, 50% Elsevier 9 publications, 50%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 3, 16.67% Royal Society of Chemistry (RSC) 3 publications, 16.67%
American Chemical Society (ACS)	American Chemical Society (ACS), 3, 16.67% American Chemical Society (ACS) 3 publications, 16.67%
Pleiades Publishing	Pleiades Publishing, 1, 5.56% Pleiades Publishing 1 publication, 5.56%
Frontiers Media S.A.	Frontiers Media S.A., 1, 5.56% Frontiers Media S.A. 1 publication, 5.56%
Springer Nature	Springer Nature, 1, 5.56% Springer Nature 1 publication, 5.56%
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Ksenofontov A. A. et al. Water-Soluble BODIPY-Based fluorescent probe for BSA and HSA detection // Journal of Molecular Liquids. 2022. Vol. 345. p. 117031.

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Ksenofontov A. A., Bocharov P. S., Ksenofontova K. V., Antina E. V. Water-Soluble BODIPY-Based fluorescent probe for BSA and HSA detection // Journal of Molecular Liquids. 2022. Vol. 345. p. 117031.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.molliq.2021.117031

UR - https://doi.org/10.1016%2Fj.molliq.2021.117031

TI - Water-Soluble BODIPY-Based fluorescent probe for BSA and HSA detection

T2 - Journal of Molecular Liquids

AU - Ksenofontov, Alexander A

AU - Bocharov, Pavel S

AU - Ksenofontova, Ksenia V

AU - Antina, Elena V

PY - 2022

DA - 2022/01/01 00:00:00

PB - Elsevier

SP - 117031

VL - 345

SN - 0167-7322

SN - 1873-3166

ER -

BibTex

Cite this

BibTex Copy

@article{2022_Ksenofontov,

author = {Alexander A Ksenofontov and Pavel S Bocharov and Ksenia V Ksenofontova and Elena V Antina},

title = {Water-Soluble BODIPY-Based fluorescent probe for BSA and HSA detection},

journal = {Journal of Molecular Liquids},

year = {2022},

volume = {345},

publisher = {Elsevier},

month = {jan},

url = {https://doi.org/10.1016%2Fj.molliq.2021.117031},

pages = {117031},

doi = {10.1016/j.molliq.2021.117031}

}

Found error?

Publisher

Elsevier

Journal

Journal of Molecular Liquids

Quartile SCImago

Quartile WOS

Impact factor

ISSN

01677322 (Print)
18733166 (Electronic)

Labs

Chemistry and molecular photonics of dipyrromethene dyes and phosphors

Profiles

	1 2
Dyes and Pigments	Dyes and Pigments, 2, 11.11% Dyes and Pigments 2 publications, 11.11%
Russian Journal of Inorganic Chemistry	Russian Journal of Inorganic Chemistry, 1, 5.56% Russian Journal of Inorganic Chemistry 1 publication, 5.56%
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy	Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 1, 5.56% Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy 1 publication, 5.56%
Coordination Chemistry Reviews	Coordination Chemistry Reviews, 1, 5.56% Coordination Chemistry Reviews 1 publication, 5.56%
Journal of Molecular Liquids	Journal of Molecular Liquids, 1, 5.56% Journal of Molecular Liquids 1 publication, 5.56%
Physical Chemistry Chemical Physics	Physical Chemistry Chemical Physics, 1, 5.56% Physical Chemistry Chemical Physics 1 publication, 5.56%
Frontiers in Bioengineering and Biotechnology	Frontiers in Bioengineering and Biotechnology, 1, 5.56% Frontiers in Bioengineering and Biotechnology 1 publication, 5.56%
Chemical Engineering Journal	Chemical Engineering Journal, 1, 5.56% Chemical Engineering Journal 1 publication, 5.56%
Journal of Applied Electrochemistry	Journal of Applied Electrochemistry, 1, 5.56% Journal of Applied Electrochemistry 1 publication, 5.56%
ACS Omega	ACS Omega, 1, 5.56% ACS Omega 1 publication, 5.56%
Organic and Biomolecular Chemistry	Organic and Biomolecular Chemistry, 1, 5.56% Organic and Biomolecular Chemistry 1 publication, 5.56%
Journal of Photochemistry and Photobiology A: Chemistry	Journal of Photochemistry and Photobiology A: Chemistry, 1, 5.56% Journal of Photochemistry and Photobiology A: Chemistry 1 publication, 5.56%
The Analyst	The Analyst, 1, 5.56% The Analyst 1 publication, 5.56%
Journal of Physical Chemistry B	Journal of Physical Chemistry B, 1, 5.56% Journal of Physical Chemistry B 1 publication, 5.56%
Journal of Molecular Structure	Journal of Molecular Structure, 1, 5.56% Journal of Molecular Structure 1 publication, 5.56%
International Journal of Biological Macromolecules	International Journal of Biological Macromolecules, 1, 5.56% International Journal of Biological Macromolecules 1 publication, 5.56%
Langmuir	Langmuir, 1, 5.56% Langmuir 1 publication, 5.56%
	1 2