Open Access
Journal of Molecular Liquids, volume 353, pages 118820
A new hydrophobic deep eutectic solvent based on thymol and 4-(dimethylamino)benzaldehyde: Derivatization and microextraction of urea
Publication type: Journal Article
Publication date: 2022-05-01
Journal:
Journal of Molecular Liquids
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 6
ISSN: 01677322, 18733166
Materials Chemistry
Electronic, Optical and Magnetic Materials
Physical and Theoretical Chemistry
Spectroscopy
Atomic and Molecular Physics, and Optics
Condensed Matter Physics
Abstract
• DES based on thymol and 4-(dimethylamino)benzaldehyde as new extractant. • Precursor (4-(dimethylamino)benzaldehyde) of DES as reagent for urea derivatization. • Simultaneous derivatization and extraction using DES. • Fast and simple extraction for urea determination in human urine and powdered milk. In this study, a deep eutectic solvent based on thymol as a hydrogen bond donor and 4-(dimethylamino)benzaldehyde as a hydrogen bond acceptor was synthesized and characterized by various methods for the first time. The new solvent is stable in the presence of water and can be considered as a hydrophobic extractant. In the presented work, this solvent was utilized for the derivatization and microextraction of urea for its determination in human urine and powdered milk samples . In the developed procedure, water-soluble analyte reacts with the hydrogen bond acceptor (4-(dimethylamino)benzaldehyde) with the formation of a colored derivative (Schiff base) followed by its mass-transfer into deep eutectic solvent phase. Combination of derivatization and extraction stages allowed to reduce sample pretreatment time and simplify the procedure for the determination of urea. The analysis time was 3 min. The limits of detection, calculated from the blank tests based on 3σ, were 0.1 mg L -1 for human urine and 2 mg kg −1 for powdered milk, RSD values were < 7 % and the enrichment factors were 24 and 23 for urine and milk samples. The procedure was successfully applied to the analysis of real samples.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Shishov A. Yu. et al. A new hydrophobic deep eutectic solvent based on thymol and 4-(dimethylamino)benzaldehyde: Derivatization and microextraction of urea // Journal of Molecular Liquids. 2022. Vol. 353. p. 118820.
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Shishov A. Yu., Shakirova F., Tolstoy P., Bulatov E., Markova U., Shakirova F. M., Bulatov A. A new hydrophobic deep eutectic solvent based on thymol and 4-(dimethylamino)benzaldehyde: Derivatization and microextraction of urea // Journal of Molecular Liquids. 2022. Vol. 353. p. 118820.
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TY - JOUR
DO - 10.1016/j.molliq.2022.118820
UR - https://doi.org/10.1016%2Fj.molliq.2022.118820
TI - A new hydrophobic deep eutectic solvent based on thymol and 4-(dimethylamino)benzaldehyde: Derivatization and microextraction of urea
T2 - Journal of Molecular Liquids
AU - Shishov, A Yu
AU - Shakirova, Firuza
AU - Tolstoy, Petr
AU - Bulatov, Evgeny
AU - Markova, Ulyana
AU - Shakirova, Firuza M
AU - Bulatov, Andrey
PY - 2022
DA - 2022/05/01 00:00:00
PB - Elsevier
SP - 118820
VL - 353
SN - 0167-7322
SN - 1873-3166
ER -
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@article{2022_Shishov,
author = {A Yu Shishov and Firuza Shakirova and Petr Tolstoy and Evgeny Bulatov and Ulyana Markova and Firuza M Shakirova and Andrey Bulatov},
title = {A new hydrophobic deep eutectic solvent based on thymol and 4-(dimethylamino)benzaldehyde: Derivatization and microextraction of urea},
journal = {Journal of Molecular Liquids},
year = {2022},
volume = {353},
publisher = {Elsevier},
month = {may},
url = {https://doi.org/10.1016%2Fj.molliq.2022.118820},
pages = {118820},
doi = {10.1016/j.molliq.2022.118820}
}