Open Access
Journal of Molecular Liquids, volume 367, pages 120502
Structural details on the interaction of fenamates with lipid membranes
Publication type: Journal Article
Publication date: 2022-12-01
Journal:
Journal of Molecular Liquids
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 6
ISSN: 01677322, 18733166
Materials Chemistry
Electronic, Optical and Magnetic Materials
Physical and Theoretical Chemistry
Spectroscopy
Atomic and Molecular Physics, and Optics
Condensed Matter Physics
Abstract
• The molecular interaction of several fenamates with POPC has been explained by various reliable NMR methods. • For fenamates were shown to penetrate the lipid membrane and are dynamically distributed within the bilayer. • The average location of molecule of fenamate into membrane in the lipid-water interface was estimated. • The binding of tolfenamic and mefenamic acid increases lipid chain order. • The flufenamic acid did not influence the lipid packing in POPC membranes. Fenamates are nonsteroidal anti-inflammatory drugs (NSAID), usually prescribed to treat pain and inflammation and, like other NSAIDs, to inhibit cyclooxygenases. They have also been proposed to show anti-epileptic and neuroprotective effects. In the current work, the interaction of several fenamates with phospholipid membranes was studied using various NMR techniques. One of the most important properties of membranes that influences the function and localization of proteins is their fluidity. Changes in membrane fluidity can also affect a drug’s ability to bind to and permeate through the membrane, which influences its efficacy. We studied the interaction of several fenamates with zwitterionic palmitoyloleoylphosphatidylcholine (POPC) membranes. Based on 1 H NMR-induced chemical shift data and quantitative analysis of 1 H MAS NOESY cross-relaxation rates, three fenamates (mefenamic, flufenamic and tolfenamic acid) were shown to penetrate the lipid membrane and are dynamically distributed within the bilayer. The average position of each drug in the lipid-water interface was also estimated from these measurements. 2 H NMR data showed that binding of tolfenamic and mefenamic acid increases lipid chain order, while flufenamic acid did not influence the lipid packing in POPC membranes.
Citations by journals
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Membranes
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3 publications, 33.33%
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2 publications, 22.22%
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Molecules
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2 publications, 22.22%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
1 publication, 11.11%
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ChemPlusChem
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ChemPlusChem
1 publication, 11.11%
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Citations by publishers
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
8 publications, 88.89%
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Wiley
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Wiley
1 publication, 11.11%
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8
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Khodov I. A. et al. Structural details on the interaction of fenamates with lipid membranes // Journal of Molecular Liquids. 2022. Vol. 367. p. 120502.
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Khodov I. A., Musabirova G. S., Klochkov V. V., Karataeva F. Kh., Huster D., Scheidt H. A. Structural details on the interaction of fenamates with lipid membranes // Journal of Molecular Liquids. 2022. Vol. 367. p. 120502.
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TY - JOUR
DO - 10.1016/j.molliq.2022.120502
UR - https://doi.org/10.1016%2Fj.molliq.2022.120502
TI - Structural details on the interaction of fenamates with lipid membranes
T2 - Journal of Molecular Liquids
AU - Khodov, Ilya A.
AU - Musabirova, Guzel S
AU - Klochkov, Vladimir V.
AU - Karataeva, Farida Kh
AU - Huster, Daniel
AU - Scheidt, Holger A
PY - 2022
DA - 2022/12/01 00:00:00
PB - Elsevier
SP - 120502
VL - 367
SN - 0167-7322
SN - 1873-3166
ER -
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@article{2022_Khodov,
author = {Ilya A. Khodov and Guzel S Musabirova and Vladimir V. Klochkov and Farida Kh Karataeva and Daniel Huster and Holger A Scheidt},
title = {Structural details on the interaction of fenamates with lipid membranes},
journal = {Journal of Molecular Liquids},
year = {2022},
volume = {367},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016%2Fj.molliq.2022.120502},
pages = {120502},
doi = {10.1016/j.molliq.2022.120502}
}
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