Open Access
Journal of Molecular Liquids, volume 367, pages 120525
Pressure effect on lidocaine conformational equilibria in scCO2: A study by 2D NOESY
Publication type: Journal Article
Publication date: 2022-12-01
Journal:
Journal of Molecular Liquids
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 6
ISSN: 01677322, 18733166
Materials Chemistry
Electronic, Optical and Magnetic Materials
Physical and Theoretical Chemistry
Spectroscopy
Atomic and Molecular Physics, and Optics
Condensed Matter Physics
Abstract
• • An approach in conducting high-pressure 2D NOESY measurements at supercritical parameters of state is discussed. • • The conformation state of lidocaine in supercritical CO 2 solution is studied by high-pressure 2D NOESY. • • The conformational change of lidocaine in relations of pressure was observed. • • This paper has potent application in the area of pharmaceutical and green chemistry. The work reports the results of an analysis of the lidocaine molecule conformational behavior in a supercritical carbon dioxide medium. Based on the nuclear Overhauser effect spectroscopy (2D NOESY) data, the authors determine the fractions of lidocaine molecule conformers in scCO 2 at temperatures and pressures exceeding the critical point (308.15 K; 10-20 MPa). The paper also shows the effect of conformational inversion for this system at 308.15 K and 22 MPa. Since lidocaine polymorphic transformations can be accompanied by changes in the molecule conformation in the crystal elemental unit cell, it is quite urgent to determine the conformer fractions of this compound.
Citations by journals
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Journal of Molecular Liquids
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Journal of Molecular Liquids
6 publications, 37.5%
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Pharmaceutics
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2 publications, 12.5%
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Russian Journal of Physical Chemistry B
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Russian Journal of Physical Chemistry B
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
2 publications, 12.5%
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Polymers
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Polymers
1 publication, 6.25%
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Materials
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Materials
1 publication, 6.25%
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Membranes
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Membranes
1 publication, 6.25%
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Citations by publishers
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
7 publications, 43.75%
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Elsevier
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Elsevier
6 publications, 37.5%
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Pleiades Publishing
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Pleiades Publishing
2 publications, 12.5%
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- We do not take into account publications that without a DOI.
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- Statistics recalculated weekly.
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Khodov I. A. et al. Pressure effect on lidocaine conformational equilibria in scCO2: A study by 2D NOESY // Journal of Molecular Liquids. 2022. Vol. 367. p. 120525.
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Khodov I. A., Belov K. V., Dyshin A. A., Krestyaninov M. A., Kiselev M. G. Pressure effect on lidocaine conformational equilibria in scCO2: A study by 2D NOESY // Journal of Molecular Liquids. 2022. Vol. 367. p. 120525.
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TY - JOUR
DO - 10.1016/j.molliq.2022.120525
UR - https://doi.org/10.1016%2Fj.molliq.2022.120525
TI - Pressure effect on lidocaine conformational equilibria in scCO2: A study by 2D NOESY
T2 - Journal of Molecular Liquids
AU - Khodov, Ilya A.
AU - Belov, Konstantin V.
AU - Dyshin, Alexey A.
AU - Krestyaninov, Mikhail A.
AU - Kiselev, M G
PY - 2022
DA - 2022/12/01 00:00:00
PB - Elsevier
SP - 120525
VL - 367
SN - 0167-7322
SN - 1873-3166
ER -
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@article{2022_Khodov,
author = {Ilya A. Khodov and Konstantin V. Belov and Alexey A. Dyshin and Mikhail A. Krestyaninov and M G Kiselev},
title = {Pressure effect on lidocaine conformational equilibria in scCO2: A study by 2D NOESY},
journal = {Journal of Molecular Liquids},
year = {2022},
volume = {367},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016%2Fj.molliq.2022.120525},
pages = {120525},
doi = {10.1016/j.molliq.2022.120525}
}
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